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Sadeghi, Abolfazl, Hoseinizadeh, Nima, Kiarad, Farzaneh, Shakibaie, Mehdi. (1402). Multi-functional effects of curcumin on breast cancer cells. سامانه مدیریت نشریات علمی, 10(1), 51-56. doi: 10.30476/tips.2024.101513.1230
Abolfazl Sadeghi; Nima Hoseinizadeh; Farzaneh Kiarad; Mehdi Shakibaie. "Multi-functional effects of curcumin on breast cancer cells". سامانه مدیریت نشریات علمی, 10, 1, 1402, 51-56. doi: 10.30476/tips.2024.101513.1230
Sadeghi, Abolfazl, Hoseinizadeh, Nima, Kiarad, Farzaneh, Shakibaie, Mehdi. (1402). 'Multi-functional effects of curcumin on breast cancer cells', سامانه مدیریت نشریات علمی, 10(1), pp. 51-56. doi: 10.30476/tips.2024.101513.1230
Sadeghi, Abolfazl, Hoseinizadeh, Nima, Kiarad, Farzaneh, Shakibaie, Mehdi. Multi-functional effects of curcumin on breast cancer cells. سامانه مدیریت نشریات علمی, 1402; 10(1): 51-56. doi: 10.30476/tips.2024.101513.1230

Multi-functional effects of curcumin on breast cancer cells

Trends in Pharmaceutical Sciences
مقاله 5، دوره 10، شماره 1، خرداد 2024، صفحه 51-56    اصل مقاله (626.63 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2024.101513.1230
نویسندگان
Abolfazl Sadeghi1؛ Nima Hoseinizadeh1؛ Farzaneh Kiarad1؛ Mehdi Shakibaie* 2، 3
1Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
2Department of Pharmaceutics and Nanotechnology, School of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran
3Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
چکیده
The rate at which cancer develops is significantly influenced by angiogenesis. The multifunctional effects of curcumin on breast cancer cells were examined in this study at the level of gene expression. Using the MTT assay, the cytotoxicity impact of curcumin was assessed. Real-time PCR was used to quantify the expression of a few genes involved in the angiogenesis, and apoptosis of MDA-231-MB cells. The results indicated that curcumin inhibited cancer proliferation in a dose- and time-dependent manner. The IC50 curcumin was about 40 µM and 15 µM after 48 h, and 96 h culture time respectively. Also, the quantitative analysis of gene expression showed that curcumin suppressed angiogenesis by decreasing the expression of VEGF and induced apoptosis by upregulation of Bax and down-regulation of Bcl-xl at the initial dose of toxicity concentration.

تازه های تحقیق

Abolfazl Sadeghi (Google Scholar)

Mehdi Shakibaie (Google Scholar)

کلیدواژه‌ها
curcumin؛ breast cancer؛ angiogenesis؛ apoptosis
مراجع
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