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Dentin Sialophosphoprotein Expression Profile in Developing Human Primary Teeth: An Experimental Study | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 اردیبهشت 1403 اصل مقاله (770.44 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2024.100219.2202 | ||
| نویسندگان | ||
| Soussan Irani* 1؛ Shohreh Alimohammadi2؛ Fatemeh Ataei3 | ||
| 1Dept. of Oral Pathology, Dental Research Centre, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran, Lecturer at Griffith University, Gold Coast, Australia. | ||
| 2Gynecologist and Perinatologist, Hamadan University of Medical Sciences, Hamadan, Iran. | ||
| 3Postgraduate Student of Prosthodontics, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran. | ||
| چکیده | ||
| Statement of the Problem: Tooth development is initiated by localized thickenings of the primary epithelial bands. Dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous protein in the dentin matrix. DSPP's expression extends to multiple tissues, including dentin, cementum, and bone. However, the role of DSPP is not yet clear in the development of human tooth. Purpose: The current study aimed to examine the DSPP expression profile during the development of human primary tooth structures with a sufficiently large sample size. Materials and Method: In this experimental study, a total of 33 samples of aborted human fetuses were divided into three age groups: <16 weeks, <19 weeks and ≥19 weeks. Immunohistochemistry (IHC) was performed with Anti-DSPP rabbit polyclonal antibody. A two-way ANOVA analysis was conducted to examine the differences between the groups (p< 0.05). Results: An increase in DSPP expression was observed with the progression of gestational weeks in different histological structures of developing human primary teeth. Conclusion: An increase in the expression level of DSPP with the progression of gestational weeks may confirm that reciprocal interactions between the enamel organ (EO) and dental pulp cells contribute to tooth formation. | ||
| کلیدواژه‌ها | ||
| Dental pulp؛ Dentin sialophosphoprotein؛ Enamel organ؛ Odontogenesis | ||
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آمار تعداد مشاهده مقاله: 95 تعداد دریافت فایل اصل مقاله: 121 |
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