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| تعداد مقالات | 10,365 |
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| تعداد دریافت فایل اصل مقاله | 10,041,103 |
Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light | ||
| Journal of Biomedical Physics and Engineering | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 04 اردیبهشت 1403 اصل مقاله (2.02 M) | ||
| نوع مقاله: Original Research | ||
| شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2312-1693 | ||
| نویسندگان | ||
| Naghmeh Sattarahmady* 1، 2؛ Zahra Kayani1، 3؛ Hossein Heli1؛ Parsa Faghani-Eskandarkolaei4؛ Hanieh Haghighi1، 2 | ||
| 1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Research Center for the Physics of Matter and Radiation, Namur Research Institute for Life Sciences, University of Namur, Belgium | ||
| 4Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Photothermal therapy (PTT) is one of the effective and non-invasive strategies which hold great promise for improving the treatment of cancer cells. PTT is based on activating a photosensitizer by infrared light irradiation and producing heat and reactive species and apoptosis in the tumor area. Objective: The aim of this study was to investigate the effect of photothermal/chemotherapy on melanoma cancer cells using poly(2-amino phenol)/gold (P2AO/AuNPs) and doxorubicin (DOX). Material and Methods: In this experimental study, nanoparticles of P2AO/AuNPs were synthesized, and their mixture with DOX was applied as a photosensitizer for photothermal/chemotherapy of a C540 (B16-F10) melanoma cell line. Results: P2AO/AuNPs generated heat and cytotoxic responsive oxygen species (ROS) upon 808-nm light irradiation with simultaneous intensifying DOX therapeutic effect under domination of synergism effects between light irradiation, P2AO/AuNPs, and doxorubicin. Cell treatment with both P2AO/AuNPs and DOX resulted in a considerable increase in necroptotic cells to 61% with a significant decrease in the living cells (39%). Conclusion: P2AO/AuNPs provided a platform for light absorption and intensifying DOX therapeutic effect. This study approved the applicability of a new photothermal/chemotherapy by domination of synergistic effects attained by combination of laser light, P2AO, AuNPs, and DOX. | ||
| کلیدواژه‌ها | ||
| Metal Nanoparticles؛ Phototherapy؛ Malignant Melanoma؛ Photoablation؛ Apoptosis؛ Doxorubicin | ||
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آمار تعداد مشاهده مقاله: 33,698 تعداد دریافت فایل اصل مقاله: 115 |
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