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Sattarahmady, Naghmeh, Kayani, Zahra, Heli, Hossein, Faghani-Eskandarkolaei, Parsa, Haghighi, Hanieh. (1403). Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light. سامانه مدیریت نشریات علمی, (), -.
Naghmeh Sattarahmady; Zahra Kayani; Hossein Heli; Parsa Faghani-Eskandarkolaei; Hanieh Haghighi. "Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light". سامانه مدیریت نشریات علمی, , , 1403, -.
Sattarahmady, Naghmeh, Kayani, Zahra, Heli, Hossein, Faghani-Eskandarkolaei, Parsa, Haghighi, Hanieh. (1403). 'Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light', سامانه مدیریت نشریات علمی, (), pp. -.
Sattarahmady, Naghmeh, Kayani, Zahra, Heli, Hossein, Faghani-Eskandarkolaei, Parsa, Haghighi, Hanieh. Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light. سامانه مدیریت نشریات علمی, 1403; (): -.

Photosensitizing Activity of Nanoparticles of Poly (2-amino phenol)/Gold for Intensified Doxorubicin Therapeutic Effect on Melanoma Cancer Cells under Synergism Effect of 808-nm Light

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 04 اردیبهشت 1403    اصل مقاله (2.02 M)
نوع مقاله: Original Research
نویسندگان
Naghmeh Sattarahmady* 1، 2؛ Zahra Kayani1، 3؛ Hossein Heli1؛ Parsa Faghani-Eskandarkolaei4؛ Hanieh Haghighi1، 2
1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Research Center for the Physics of Matter and Radiation, Namur Research Institute for Life Sciences, University of Namur, Belgium
4Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Photothermal therapy (PTT) is one of the effective and non-invasive strategies which hold great promise for improving the treatment of cancer cells. PTT is based on activating a photosensitizer by infrared light irradiation and producing heat and reactive species and apoptosis in the tumor area.
Objective: The aim of this study was to investigate the effect of photothermal/chemotherapy on melanoma cancer cells using poly(2-amino phenol)/gold (P2AO/AuNPs) and doxorubicin (DOX).
Material and Methods: In this experimental study, nanoparticles of P2AO/AuNPs were synthesized, and their mixture with DOX was applied as a photosensitizer for photothermal/chemotherapy of a C540 (B16-F10) melanoma cell line.
Results: P2AO/AuNPs generated heat and cytotoxic responsive oxygen species (ROS) upon 808-nm light irradiation with simultaneous intensifying DOX therapeutic effect under domination of synergism effects between light irradiation, P2AO/AuNPs, and doxorubicin. Cell treatment with both P2AO/AuNPs and DOX resulted in a considerable increase in necroptotic cells to 61% with a significant decrease in the living cells (39%). 
Conclusion: P2AO/AuNPs provided a platform for light absorption and intensifying DOX therapeutic effect. This study approved the applicability of a new photothermal/chemotherapy by domination of synergistic effects attained by combination of laser light, P2AO, AuNPs, and DOX.
کلیدواژه‌ها
Metal Nanoparticles؛ Phototherapy؛ Malignant Melanoma؛ Photoablation؛ Apoptosis؛ Doxorubicin
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