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Mortazavi, Seyed Mohammad Javad Mortazavi, Zare, Omid, Ghasemi, Leyla, Taghizadeh, Parmis, Faghani-Eskandarkolaei, Parsa, Arshadi, Maryam, Mortazavi, Seyed Ali Reza, Sihver, Lembit. (1403). A Reexamination of Peto’s Paradox: Insights Gained from Human Adaptation to Varied Levels of Ionizing and Non-ionizing Radiation. سامانه مدیریت نشریات علمی, 14(3), 309-314. doi: 10.31661/jbpe.v0i0.2402-1729
Seyed Mohammad Javad Mortazavi Mortazavi; Omid Zare; Leyla Ghasemi; Parmis Taghizadeh; Parsa Faghani-Eskandarkolaei; Maryam Arshadi; Seyed Ali Reza Mortazavi; Lembit Sihver. "A Reexamination of Peto’s Paradox: Insights Gained from Human Adaptation to Varied Levels of Ionizing and Non-ionizing Radiation". سامانه مدیریت نشریات علمی, 14, 3, 1403, 309-314. doi: 10.31661/jbpe.v0i0.2402-1729
Mortazavi, Seyed Mohammad Javad Mortazavi, Zare, Omid, Ghasemi, Leyla, Taghizadeh, Parmis, Faghani-Eskandarkolaei, Parsa, Arshadi, Maryam, Mortazavi, Seyed Ali Reza, Sihver, Lembit. (1403). 'A Reexamination of Peto’s Paradox: Insights Gained from Human Adaptation to Varied Levels of Ionizing and Non-ionizing Radiation', سامانه مدیریت نشریات علمی, 14(3), pp. 309-314. doi: 10.31661/jbpe.v0i0.2402-1729
Mortazavi, Seyed Mohammad Javad Mortazavi, Zare, Omid, Ghasemi, Leyla, Taghizadeh, Parmis, Faghani-Eskandarkolaei, Parsa, Arshadi, Maryam, Mortazavi, Seyed Ali Reza, Sihver, Lembit. A Reexamination of Peto’s Paradox: Insights Gained from Human Adaptation to Varied Levels of Ionizing and Non-ionizing Radiation. سامانه مدیریت نشریات علمی, 1403; 14(3): 309-314. doi: 10.31661/jbpe.v0i0.2402-1729

A Reexamination of Peto’s Paradox: Insights Gained from Human Adaptation to Varied Levels of Ionizing and Non-ionizing Radiation

Journal of Biomedical Physics and Engineering
دوره 14، شماره 3، مرداد و شهریور 2024، صفحه 309-314    اصل مقاله (678.19 K)
نوع مقاله: Mini Review
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2402-1729
نویسندگان
Seyed Mohammad Javad Mortazavi Mortazavi1؛ Omid Zare2؛ Leyla Ghasemi2؛ Parmis Taghizadeh3؛ Parsa Faghani-Eskandarkolaei2؛ Maryam Arshadi2؛ Seyed Ali Reza Mortazavi4؛ Lembit Sihver* 5، 6، 7
1Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4MVLS College, The University of Glasgow, Glasgow, Scotland, United Kingdom
5Department of Physics, East Carolina University, Greenville, USA
6Royal Military College of Canada, Kingston, ON, Canada
7Department of Radiation Physics, Technische Universität Wien, Atominstitut, Vienna, Austria
چکیده
Humans have generally evolved some adaptations to protect against UV and different levels of background ionizing radiation. Similarly, elephants and whales have evolved adaptations to protect against cancer, such as multiple copies of the tumor suppressor gene p53, due to their large size and long lifespan. The difference in cancer protection strategies between humans and elephants/whales depends on genetics, lifestyle, environmental exposures, and evolutionary pressures. In this paper, we discuss how the differences in evolutionary adaptations between humans and elephants could explain why elephants have evolved a protective mechanism against cancer, whereas humans have not. Humans living in regions with high levels of background radiation, e.g. in Ramsar, Iran where exposure rates exceed those on the surface of Mars, seem to have developed some kind of protection against the ionizing radiation. However, humans in general have not developed cancer-fighting adaptations, so they instead rely on medical technologies and interventions. The difference in cancer protection strategies between humans and elephants/whales depends on genetics, lifestyle, environmental exposures, and evolutionary pressures. In this paper, we discuss how the differences in evolutionary adaptations between humans and elephants could explain why elephants have evolved a protective mechanism against cancer, whereas humans have not. Studying elephant adaptations may provide insights into new cancer prevention and treatment strategies for humans, but further research is required to fully understand the evolutionary disparities.

تازه های تحقیق

Seyed Mohammad Javad Mortazavi (Google Scholar)

Lembit Sihver (Google Scholar)

کلیدواژه‌ها
Carcinogenesis؛ Radiation؛ Biological Evolution؛ Radiobiology؛ Peto’s Paradox, Evolution
سایر فایل های مرتبط با مقاله
مراجع
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