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Faraji, Shahab, Rajaeinejad, Mohsen, Bagheri, Hamed, Afshar Ardalan, Mohammad, Moutabian, Hossein, Ehsani, Faramarz, Pourarjmand, Mohammad, Mirshafieyan, Samira Sadat, Alazamani, Farshid, Cheraghi, Susan. (1403). Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-based Quantification. سامانه مدیریت نشریات علمی, (), -.
Shahab Faraji; Mohsen Rajaeinejad; Hamed Bagheri; Mohammad Afshar Ardalan; Hossein Moutabian; Faramarz Ehsani; Mohammad Pourarjmand; Samira Sadat Mirshafieyan; Farshid Alazamani; Susan Cheraghi. "Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-based Quantification". سامانه مدیریت نشریات علمی, , , 1403, -.
Faraji, Shahab, Rajaeinejad, Mohsen, Bagheri, Hamed, Afshar Ardalan, Mohammad, Moutabian, Hossein, Ehsani, Faramarz, Pourarjmand, Mohammad, Mirshafieyan, Samira Sadat, Alazamani, Farshid, Cheraghi, Susan. (1403). 'Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-based Quantification', سامانه مدیریت نشریات علمی, (), pp. -.
Faraji, Shahab, Rajaeinejad, Mohsen, Bagheri, Hamed, Afshar Ardalan, Mohammad, Moutabian, Hossein, Ehsani, Faramarz, Pourarjmand, Mohammad, Mirshafieyan, Samira Sadat, Alazamani, Farshid, Cheraghi, Susan. Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-based Quantification. سامانه مدیریت نشریات علمی, 1403; (): -.

Modulation of Ionizing Radiation-Induced Apoptosis by Taurine in Human Peripheral Blood Lymphocytes: Flow Cytometry-based Quantification

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 01 اردیبهشت 1403    اصل مقاله (1.99 M)
نوع مقاله: Original Research
نویسندگان
Shahab Faraji1؛ Mohsen Rajaeinejad2؛ Hamed Bagheri* 1، 2؛ Mohammad Afshar Ardalan2؛ Hossein Moutabian2؛ Faramarz Ehsani2؛ Mohammad Pourarjmand2؛ Samira Sadat Mirshafieyan1؛ Farshid Alazamani2؛ Susan Cheraghi1
1Radiation Biology Research Center, Iran University of Medical Science (IUMS), Tehran, Iran
2Radiation Sciences Research Center (ARSRC), Aja University of Medical Sciences, Tehran, Iran
چکیده
Background: Radiotherapy, a highly effective method of radiation-based treating cancers, can reduce the size of tumors and affect healthy tissues. Radiation-induced lymphopenia as a side effect of radiation therapy can reduce the effectiveness of the treatment.
Objective: This study aimed to examine how taurine can protect peripheral blood lymphocytes from radiation-based apoptosis.
Material and Methods: In this experimental study, the effects of the taurine on lymphocytes were studied, and blood samples were divided into three groups: a negative control group that was not treated, a positive control group that was treated with cysteine (100 μg/ml), and a group that was treated with taurine (100 µg. mL-1) in three different doses (4, 8 & 12 Gy) before irradiation. The percentage of apoptotic and necrotic lymphocytes was measured using flow cytometry 48 and 72 hours after the irradiation, respectively.
Results: According to the groups treated with taurine, the number of lymphocytes undergoing apoptosis was lower and higher compared to the negative and positive control groups, respectively. The decrease in this value was more pronounced 48 hours after radiation compared to 72 hours. Furthermore, there was a slight increase in the number of apoptotic lymphocytes with increasing radiation dose. 
Conclusion: Taurine effectively protects human peripheral blood lymphocytes from radiation-based apoptosis.
کلیدواژه‌ها
Taurine؛ Apoptosis؛ Flow Cytometry؛ Lymphocyte؛ Radioprotective؛ Ionizing Radiation
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