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Keshavarzi, Omid, Haddadi, Gholamhassan, Fardid, Reza, Haghani, Masoud Haghani, Kalantari, Tahereh, Namdari, Azadeh. (1403). Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region. سامانه مدیریت نشریات علمی, (), -.
Omid Keshavarzi; Gholamhassan Haddadi; Reza Fardid; Masoud Haghani Haghani; Tahereh Kalantari; Azadeh Namdari. "Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region". سامانه مدیریت نشریات علمی, , , 1403, -.
Keshavarzi, Omid, Haddadi, Gholamhassan, Fardid, Reza, Haghani, Masoud Haghani, Kalantari, Tahereh, Namdari, Azadeh. (1403). 'Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region', سامانه مدیریت نشریات علمی, (), pp. -.
Keshavarzi, Omid, Haddadi, Gholamhassan, Fardid, Reza, Haghani, Masoud Haghani, Kalantari, Tahereh, Namdari, Azadeh. Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region. سامانه مدیریت نشریات علمی, 1403; (): -.

Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 21 فروردین 1403    اصل مقاله (930.07 K)
نوع مقاله: Original Research
نویسندگان
Omid Keshavarzi1؛ Gholamhassan Haddadi1، 2؛ Reza Fardid1، 2؛ Masoud Haghani Haghani* 1، 2؛ Tahereh Kalantari3؛ Azadeh Namdari4
1Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
2Ionizing and Nonionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran
3Research Center for Diagnostic Laboratory Science and Technology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Member of the Diagnostic Laboratory Science and Technology Research Center, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Industrial radiography uses gamma or X-ray radionuclide sources to investigate the safety of industrial materials. Industrial radiation workers receive the highest occupational radiation doses.
Objective: The present study investigates the relationship between Bax and Bcl-2 gene expression variables in industrial radiation workers.
Material and Methods: In this case-control study, data was collected using blood sampling from 40 workers, including two groups of non-radiation and radiation workers employed at the location. Expression levels of Bax and Bcl-2 genes were assessed in the laboratory. The environmental and absorbed doses of workers were measured using environmental and pen dosimeters.
Results: Statistical analysis showed that the radiation group’s Bcl-2 gene expression level was significantly higher. Findings also demonstrated a correlation between Bcl-2 gene expression and the number of workdays. Also, the Bax gene expression did not show a significant change, and the expression ratio of Bax/Bcl-2 was insignificant in the two groups. 
Conclusion: Exposure to low doses of radiation could promote an adaptive
response in cells by increasing Bcl-2 gene expression.
کلیدواژه‌ها
Industrial Radiography؛ Bax Gene؛ Bcl-2 Gene؛ Peripheral Blood؛ Lymphocytes؛ Radiation Workers؛ Asaluyeh؛ Gammagraphy؛ Apoptosis؛ Real-Time Polymerase Chain Reaction
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