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Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region | ||
Journal of Biomedical Physics and Engineering | ||
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 21 فروردین 1403 اصل مقاله (930.07 K) | ||
نوع مقاله: Original Research | ||
نویسندگان | ||
Omid Keshavarzi1؛ Gholamhassan Haddadi1، 2؛ Reza Fardid1، 2؛ Masoud Haghani Haghani* 1، 2؛ Tahereh Kalantari3؛ Azadeh Namdari4 | ||
1Department of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran | ||
2Ionizing and Nonionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran | ||
3Research Center for Diagnostic Laboratory Science and Technology, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
4Member of the Diagnostic Laboratory Science and Technology Research Center, Faculty of Paramedicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
چکیده | ||
Background: Industrial radiography uses gamma or X-ray radionuclide sources to investigate the safety of industrial materials. Industrial radiation workers receive the highest occupational radiation doses. Objective: The present study investigates the relationship between Bax and Bcl-2 gene expression variables in industrial radiation workers. Material and Methods: In this case-control study, data was collected using blood sampling from 40 workers, including two groups of non-radiation and radiation workers employed at the location. Expression levels of Bax and Bcl-2 genes were assessed in the laboratory. The environmental and absorbed doses of workers were measured using environmental and pen dosimeters. Results: Statistical analysis showed that the radiation group’s Bcl-2 gene expression level was significantly higher. Findings also demonstrated a correlation between Bcl-2 gene expression and the number of workdays. Also, the Bax gene expression did not show a significant change, and the expression ratio of Bax/Bcl-2 was insignificant in the two groups. Conclusion: Exposure to low doses of radiation could promote an adaptive response in cells by increasing Bcl-2 gene expression. | ||
کلیدواژهها | ||
Industrial Radiography؛ Bax Gene؛ Bcl-2 Gene؛ Peripheral Blood؛ Lymphocytes؛ Radiation Workers؛ Asaluyeh؛ Gammagraphy؛ Apoptosis؛ Real-Time Polymerase Chain Reaction | ||
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