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Ariafar, Ali, Kohansal, Erfan, Mousania, Amirhassan, Faghih, Zahra. (1403). Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications. سامانه مدیریت نشریات علمی, 21(2), 121-131. doi: 10.22034/iji.2024.100799.2714
Ali Ariafar; Erfan Kohansal; Amirhassan Mousania; Zahra Faghih. "Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications". سامانه مدیریت نشریات علمی, 21, 2, 1403, 121-131. doi: 10.22034/iji.2024.100799.2714
Ariafar, Ali, Kohansal, Erfan, Mousania, Amirhassan, Faghih, Zahra. (1403). 'Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications', سامانه مدیریت نشریات علمی, 21(2), pp. 121-131. doi: 10.22034/iji.2024.100799.2714
Ariafar, Ali, Kohansal, Erfan, Mousania, Amirhassan, Faghih, Zahra. Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications. سامانه مدیریت نشریات علمی, 1403; 21(2): 121-131. doi: 10.22034/iji.2024.100799.2714

Natural Killer Cell Subsets in Tumor Draining Lymph Nodes of Patients with Bladder Cancer and Their Clinical Implications

Iranian Journal of Immunology
دوره 21، شماره 2، شهریور 2024، صفحه 121-131    اصل مقاله (3.03 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2024.100799.2714
نویسندگان
Ali Ariafar1؛ Erfan Kohansal2؛ Amirhassan Mousania1؛ Zahra Faghih* 2
1Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: Natural killer (NK) cells are crucial innate components in anti-tumor immunity. However, the clinical impacts and their phenotypes in bladder cancer (BC) remain unclear.
Objective: To assess the clinical significance of NK cell subsets in tumor-draining lymph nodes of patients with BC.
Methods: In a cross-sectional study, pelvic lymph nodes were obtained from 49 untreated patients with BC. Mononuclear cells were isolated and immunophenotyped using CD3, CD56, CD16, CD27, and CD11b markers. NK cells were then classified based on their expression patterns of CD56/CD16 (conventional) and CD27/CD11b (new).
Results: On average, NK cells constituted 2.99±1.44% of the total lymphocytes in the draining lymph node of patients with BC. The CD56dim and regulatory NK subsets (CD27+CD11b+/-) were the predominant old and new NK, respectively. The NK cells significantly increased in patients with at least one involved node (LN+) compared with those with free nodes (LN-; p=0.022). Conversely, CD56dimCD16- subset significantly decreased in higher stages (p=0.032) and in tumors with muscle invasion (p=0.038). Significant variations were also observed in different T-stages (p<0.05). Regarding new classification, the frequency of CD11b+ regulatory NK cells was significantly lower in node-positive patients (p=0.025).
Conclusion: These findings emphasize the dynamic nature of NK cell subsets in bladder cancer and their potential relevance in disease progression and management, suggesting potential implications for therapeutic strategies targeting these specific subsets.
کلیدواژه‌ها
Bladder Cancer؛ Draining Lymph Node؛ Natural Killer (NK) Cells؛ NK Subsets
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