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Naderisorki, Mohammad, Karami, Hossein, Salehifar, Ebrahim, Jafari, Helieh. (1403). The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 15(4), 297-306. doi: 10.30476/mejc.2024.100100.1971
Mohammad Naderisorki; Hossein Karami; Ebrahim Salehifar; Helieh Jafari. "The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 15, 4, 1403, 297-306. doi: 10.30476/mejc.2024.100100.1971
Naderisorki, Mohammad, Karami, Hossein, Salehifar, Ebrahim, Jafari, Helieh. (1403). 'The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 15(4), pp. 297-306. doi: 10.30476/mejc.2024.100100.1971
Naderisorki, Mohammad, Karami, Hossein, Salehifar, Ebrahim, Jafari, Helieh. The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1403; 15(4): 297-306. doi: 10.30476/mejc.2024.100100.1971

The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial

Middle East Journal of Cancer
مقاله 5، دوره 15، شماره 4 - شماره پیاپی 60، دی 2024، صفحه 297-306    اصل مقاله (658.78 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2024.100100.1971
نویسندگان
Mohammad Naderisorki* 1؛ Hossein Karami2؛ Ebrahim Salehifar2؛ Helieh Jafari3
1Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
2Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Acute lymphoblastic leukemia (ALL) represents the predominant childhood cancer. High-dose methotrexate is integral to leukemia treatment protocols. This study aimed to explore the efficacy of glutamine in preventing mucositis among leukemia patients undergoing high-dose methotrexate therapy.
Method: This randomized clinical trial encompassed 45 patients (22 in the glutamine group and 23 in the placebo group). The intervention group was administered a glutamine mouthwash, while the control group received an identical placebo. Data analysis was performed using SPSS version 23, with a significance threshold set at P < 0.05.
Results: No significant difference emerged between the groups concerning the incidence of nausea and vomiting; however, both groups observed a notable reduction in nausea frequency from the first to the fourth days (P = 0.0001 and P = 0.040, respectively). Grades III and IV mucositis were absent in both groups on the third and seventh days post-treatment. Furthermore, no significant difference was detected in mucositis improvement between the groups (P = 0.848).
Conclusion: Glutamine mouthwash significantly reduced the incidence of nausea and vomiting, which are common chemotherapy complications. Moreover, up to 95% of patients were free from mucositis by the seventh-day post-chemotherapy.

تازه های تحقیق

Mohammad Naderisorki (PubMed)

کلیدواژه‌ها
Glutamine؛ Chemotherapy؛ Mucositis؛ Child
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