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Saravani, Shirin, Nemati Rezvani, amed, Shahraki, Mehrdad, Kadeh, Hamideh. (1403). A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes. سامانه مدیریت نشریات علمی, 49(8), 508-514. doi: 10.30476/ijms.2023.98602.3121
Shirin Saravani; amed Nemati Rezvani; Mehrdad Shahraki; Hamideh Kadeh. "A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes". سامانه مدیریت نشریات علمی, 49, 8, 1403, 508-514. doi: 10.30476/ijms.2023.98602.3121
Saravani, Shirin, Nemati Rezvani, amed, Shahraki, Mehrdad, Kadeh, Hamideh. (1403). 'A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes', سامانه مدیریت نشریات علمی, 49(8), pp. 508-514. doi: 10.30476/ijms.2023.98602.3121
Saravani, Shirin, Nemati Rezvani, amed, Shahraki, Mehrdad, Kadeh, Hamideh. A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes. سامانه مدیریت نشریات علمی, 1403; 49(8): 508-514. doi: 10.30476/ijms.2023.98602.3121

A Comparison of Immunohistochemical Expression of Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor 2 in Dental Follicles with Different Radiographic Sizes

Iranian Journal of Medical Sciences
مقاله 6، دوره 49، شماره 8، آبان 2024، صفحه 508-514    اصل مقاله (1.07 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.98602.3121
نویسندگان
Shirin Saravani1؛ amed Nemati Rezvani2؛ Mehrdad Shahraki2؛ Hamideh Kadeh* 1
1Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
2Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
چکیده
Background: Odontogenic cysts and tumors develop from the dental follicle of asymptomatic impacted teeth. Odontogenic tissues express the epidermal growth factor receptor family (EGFR), which mediates cell proliferation, survival, and neoplastic differentiation. The present study aimed to compare the immunohistochemical expression of EGFR and human epidermal growth factor receptor 2 (HER2) in the dental follicle of impacted wisdom teeth with normal and abnormal radiographic size.
Methods: In this analytical study, immunohistochemical staining of EGFR and HER2 was performed on 30 normal and 30 abnormal follicles of impacted third molars. Follicles with a width of <2.5 mm were considered normal, whereas those with a width of ≥2.5 mm were regarded as abnormal. The immunoreactive score (IRS) was used to report the expression levels of EGFR and HER2. The obtained data were analyzed using SPSS software. Age and sex were compared in normal and abnormal groups with independent t test and Chi square test, respectively. P<0.05 was considered statistically significant.
Results: The EGFR and HER2 overall expression was high in all normal and abnormal follicles. The comparison of the percentage of stained cells and intensity of EGFR and HER2 staining in normal and abnormal follicles were not significantly different (P=0.73, P=0.63, P=0.95, respectively). 
Conclusion: Due to the high expression of EGFR and HER2 in normal and abnormal follicles, as well as the lack of significant differences in these two groups, the radiographic size of dental follicles might not indicate the potential capabilities of their cells, and more research in this field is recommended.
کلیدواژه‌ها
ErbB receptors؛ Dental sac؛ Molar, third؛ Radiography؛ Tooth extraction
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مراجع
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