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Sameh, Reham, Qasem, Ebtisam, Abozaid, Eslam, Abdelsalam, Mohamed, Elaidy, Noha. (1403). Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study. سامانه مدیریت نشریات علمی, 15(4), 289-296. doi: 10.30476/mejc.2024.99977.1966
Reham Sameh; Ebtisam Ragab Qasem; Eslam Gamal Abozaid; Mohamed Mohamed Abdelsalam; Noha Farouk Elaidy. "Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study". سامانه مدیریت نشریات علمی, 15, 4, 1403, 289-296. doi: 10.30476/mejc.2024.99977.1966
Sameh, Reham, Qasem, Ebtisam, Abozaid, Eslam, Abdelsalam, Mohamed, Elaidy, Noha. (1403). 'Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study', سامانه مدیریت نشریات علمی, 15(4), pp. 289-296. doi: 10.30476/mejc.2024.99977.1966
Sameh, Reham, Qasem, Ebtisam, Abozaid, Eslam, Abdelsalam, Mohamed, Elaidy, Noha. Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study. سامانه مدیریت نشریات علمی, 1403; 15(4): 289-296. doi: 10.30476/mejc.2024.99977.1966

Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study

Middle East Journal of Cancer
مقاله 4، دوره 15، شماره 4 - شماره پیاپی 60، دی 2024، صفحه 289-296    اصل مقاله (122.74 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2024.99977.1966
نویسندگان
Reham Sameh1؛ Ebtisam Ragab Qasem* 2؛ Eslam Gamal Abozaid3؛ Mohamed Mohamed Abdelsalam4؛ Noha Farouk Elaidy1
1Pathology Department, Faculty of Medicine, Zagazig University, Egypt
2Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Egypt
3Surgical Oncology Department, Faculty of Medicine, Zagazig University, Egypt
4Obstetrics and Gynecology Department, AlAhrar Teaching Hospital, Zagazig, Egypt
چکیده
Background: Triple-negative breast cancer (TNBC) is characterized by a poor prognosis. Consequently, the current research aims to identify new therapeutic targets for TNBC patients. Trichorhinophalangeal syndrome type 1 (TRPS1), a novel GATA transcription factor, and CYP4Z1, a fatty acid hydroxylase, present potential targets for novel therapies.
Method: This retrospective study included 70 TNBC patients. The immunohistochemical expression of TRPS1, GATA3, and CYP4Z1 was evaluated. Data regarding the patient's clinical and pathological responses to chemotherapy were collected and analyzed for response assessment. SPSS version 20 software facilitated the data analysis. Quantitative variables were described using means and standard deviations, whereas categorical variables were examined using the chi-square test or Fisher's exact test as appropriate. Survival analysis was performed using Kaplan-Meier plots, including disease-free and overall survival. A P-value of less than 0.05 was considered statistically significant.
Results: The analysis showed that 37 cases (53%) were positive for TRPS1 expression, 45 cases (65%) for GATA3, and 40 cases (57%) for CYP4Z1. There was a significant association between the expression of GATA3, TRPS1, and CYP4Z1 and various prognostic factors such as tumor size, grade, stage, lymphovascular invasion, recurrence, and mortality. Notably, the overall recurrence and progression rates were significantly correlated with the overexpression of GATA3, TRPS1, and CYP4Z1.
Conclusion: The overexpression of TRPS1, GATA3, and CYP4Z1 in TNBC patients may be novel prognostic factors for predicting tumor prognosis. Furthermore, these markers could assist in selecting patients for future therapies in both localized and metastatic breast carcinoma settings.

تازه های تحقیق

Reham Sameh (PubMed)

کلیدواژه‌ها
Prognosis؛ Immunohistochemical؛ Significance؛ CYP4Z1 Protein؛ Therapy
مراجع
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