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| تعداد دریافت فایل اصل مقاله | 11,292,105 |
Pathologic Features of Breast Malignancies Undergoing Surgery and Evaluation of Neo-Adjuvant Therapy Efficiency in Shiraz, Iran: A Cross-Sectional Multidimensional Study | ||
| Middle East Journal of Cancer | ||
| دوره 15، 2_Supplement، تیر 2024 اصل مقاله (330.96 K) | ||
| نوع مقاله: Poster | ||
| نویسندگان | ||
| Mohammadali Moghimizadeh1؛ Mansoureh Shokripour2؛ Aref Hafezi Bafti1؛ Navid Omidifar* 2 | ||
| 1Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Background: Breast cancer, the most prevalent cancer among women, represented 25.4% of all female cancer cases in 2020. Neo-adjuvant chemotherapy has significantly enhanced survival rates and surgical outcomes. This study investigates the pathologic characteristics of breast cancer and their correlations with critical factors in Shiraz, Iran. Method: This cross-sectional study analyzed 280 pathological reports from Faghihi Hospital in Shiraz, Iran, of patients with histologically confirmed breast cancer; the Named Entity Recognition (NER) technique extracted information from unstructured reports using cancer-related keywords and staging. For structured report sections, text extraction followed specific keyword identification. A physician-supervised the keyword selection and extraction process throughout. Results: The average tumor size was 32.3 mm, with 1.4% of breast cancer cases occurring in men (female to male ratio = 70:1). Utilizing the Nottingham grading system, it was observed that most tumors were of higher grade, indicating a higher probability of recurrence. As tumors increased in size, tubular, nuclear, and mitotic indices also rose significantly (T: 0.61, N: 0.73, M: 0.73; P < 0.001), suggesting that tumor enlargement not only leads to tissue invasion but also enhances malignant cell aggressiveness. The majority of patients were classified as TNM stage IIA. Patients responding to neo-adjuvant therapy had an average tumor size of 2.13 cm, compared with 4.56 cm in non-responders, with each centimeter increase in size raising the likelihood of treatment failure by 34% (P = 0.015). Conclusion: The mean tumor size in Iran is approximately double that of some other countries, highlighting the need for an improved screening system. The relatively low female-to-male ratio suggests that male screening could benefit the Iranian demographic. Further research is warranted to establish a size-based threshold for initiating neo-adjuvant therapy. | ||
| کلیدواژهها | ||
| Breast cancer؛ Neo-adjuvant chemotherapy؛ Predictive factors | ||
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آمار تعداد مشاهده مقاله: 121 تعداد دریافت فایل اصل مقاله: 219 |
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