A designed model of urinary stone formation and the effect of Lapis judaicus on urinary parameters in rat | ||
| Trends in Pharmaceutical Sciences and Technologies | ||
| مقاله 5، دوره 9، شماره 4، زمستان 2023، صفحه 271-278 اصل مقاله (411.77 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/tips.2024.98734.1202 | ||
| نویسندگان | ||
| Mohammad Javad Khoshnoud* 1؛ Pouya Faridi2؛ Reza Setayesh1؛ Bahareh Baniani1؛ Amir Reza Dehghanian3 | ||
| 1Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Victoria, Australia. | ||
| 3Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Urinary stones after urinary tract infections and prostate disorders are the third most common urinary tract diseases. In recent years various herbal medicines for preventing or treating renal stones have been marketed and may be helpful in prevention and treatment, but still effectiveness and safe drug therapy without surgical intervention is controversial. This study aimed to evaluate the effects of L. judaicus in the treatment of urinary stones. In order to form stone in an animal model, 1% Ethylene Glycol (EG) dissolved in drinking water was used. Forty rats were divided into eight groups. After 45 days of drug administration, to determine the effects of the drug on urinary and serum parameters, 24-hour urine and blood samples were obtained. Then animals were sacrificed and kidneys were sent to the pathology laboratory for histological examination. Results of our study showed that prescribing L. judaicus in the co-treatment group reduced serum BUN, elevated urinary citrate and urine pH, and reduced urinary parameters such as urine protein, calcium, oxalate, phosphorus, and creatinine, therefore L. judaicus is effective in inhibition of urinary stones formation. Histopathologic results showed a decline of urinary stones in L. judaicus groups in comparison with ethylene glycol group. | ||
تازه های تحقیق | ||
Mohammad Javad Khoushnoud (Google Scholar) | ||
| کلیدواژهها | ||
| Ethylene glycol؛ Urinary stone؛ Lapis judaicus؛ Urine | ||
| مراجع | ||
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