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Ajdari, Mohammadreza, Ranjbar, Aliyeh, Karimian, Khashayar, Karimi, Maryam, Heli, Hossein, Sattarahmady, Naghmeh. (1403). Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines. سامانه مدیریت نشریات علمی, 14(2), 159-168. doi: 10.31661/jbpe.v0i0.2401-1708
Mohammadreza Ajdari; Aliyeh Ranjbar; Khashayar Karimian; Maryam Karimi; Hossein Heli; Naghmeh Sattarahmady. "Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines". سامانه مدیریت نشریات علمی, 14, 2, 1403, 159-168. doi: 10.31661/jbpe.v0i0.2401-1708
Ajdari, Mohammadreza, Ranjbar, Aliyeh, Karimian, Khashayar, Karimi, Maryam, Heli, Hossein, Sattarahmady, Naghmeh. (1403). 'Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines', سامانه مدیریت نشریات علمی, 14(2), pp. 159-168. doi: 10.31661/jbpe.v0i0.2401-1708
Ajdari, Mohammadreza, Ranjbar, Aliyeh, Karimian, Khashayar, Karimi, Maryam, Heli, Hossein, Sattarahmady, Naghmeh. Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines. سامانه مدیریت نشریات علمی, 1403; 14(2): 159-168. doi: 10.31661/jbpe.v0i0.2401-1708

Characterization and Evaluation of Nano-niosomes Encapsulating Docetaxel against Human Breast, Pancreatic, and Pulmonary Adenocarcinoma Cancer Cell Lines

Journal of Biomedical Physics and Engineering
دوره 14، شماره 2، تیر 2024، صفحه 159-168    اصل مقاله (885.06 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2401-1708
نویسندگان
Mohammadreza Ajdari1؛ Aliyeh Ranjbar1؛ Khashayar Karimian2؛ Maryam Karimi1؛ Hossein Heli1؛ Naghmeh Sattarahmady* 1، 3
1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Arasto Pharmaceutical Chemicals Inc., Yousefabad, Jahanarar Avenue, Tehran, Iran
3Department of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Docetaxel (DXL) is an antineoplastic agent for cancer treatment, the therapeutic efficiency of which is limited due to low solubility, hydrophobicity, and tissue specificity.
Objective: In this study, nano-niosomes were introduced for improving therapeutic index of DXL.
Material and Methods: In this experimental study, two nano-niosomes were synthesized using Span 20® and Span 80® and a thin film hydration method with DXL loading (DXL-Span20 and DXL-Span80). Characterization, in-vitro cytotoxicity and bioavailability of the nano-niosomes was also evaluated via in-vivo experiments.
Results: DXL-Span20 and DXL-Span80 have vesicles size in a range of 84-90 nm and negative zeta potentials. DXL entrapment efficiencies were obtained as 69.6 and 74.0% for DXL-Span20 and DXL-Span80, respectively; with an in-vitro sustained release patterns. Cytotoxicity assays were performed against MDA-MB-231, Calu-6, and AsPC-1 cell lines, and the results indicated that DXL loading into nano-niosomes led to decrement in values of half-maximal inhibitory concentration (IC50) at least 2.5 times and at most 6.5 times, compared to free DXL. Moreover, the rat blood bioavailability of DXL after intraperitoneal administration and the pharmacokinetic parameters indicated higher DXL plasma level and the higher effectiveness of DXL-Span80 compared to DXL-Span20. 
Conclusion: Carrying DXL by the nano-niosomes led to enhanced cytotoxicity (and lower IC50 values) and higher efficacy with enhanced pharmacokinetic parameters.

تازه های تحقیق

Naghmeh Sattarahmady (Google Scholar)

کلیدواژه‌ها
Docetaxel؛ Taxane؛ Taxotere®؛ Niosome؛ Sorbitan Monolaurate؛ Drug Delivery Systems
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