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Antibiotic Resistance to Pseudomonas Aeruginosa in the Saliva of Candidates of Bone Marrow Transplantation | ||
| Journal of Dentistry | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 07 اسفند 1402 اصل مقاله (469.53 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/dentjods.2024.100492.2225 | ||
| نویسندگان | ||
| Maryam Zahed1؛ Mojtaba Safvat2؛ Abdollah Bazargani3؛ Janan Ghapanchi4؛ Zahra Ranjbar* 1 | ||
| 1Oral and Dental Disease Research Center, Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 2Undergraduate Student, Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 3Dept. of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| 4Dept. of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. | ||
| چکیده | ||
| Statement of the Problem: Opportunistic infections such as Pseudomonas aeruginosa, colonized from the oral cavity, are common in candidates of bone marrow transplantation. Therefore, it is important to prescribe appropriate antibiotics for this group of debilitated patients. Purpose: In this study, we aimed to investigate the antibiotic resistance to Pseudomonas aeruginosa encountered in candidates of bone marrow transplantation referred to Imam Reza Clinic, Namazi Hospital, and Amir Hospital, Shiraz, Iran. Materials and Method: This cross-sectional study was performed on 30 patients with leukemia and lymphoma. To identify Pseudomonas species, saliva samples were collected and cultured in a blood agar medium. Considering the present therapies, we examined the antibiotic sensitivity of Penicillin, Oxacillin, Gentamicin, Tetracycline, Cefepime, Ciprofloxacin, Imipenem, Ceftazidime, Cefotaxime, Erythromycin, Trimethoprim, Sulfamethoxazole, and Vancomycin. Statistical analysis was performed using chi-square test (χ2) and SPSS software. P value < 0.05 was considered significant. Results: In 10 patients out of 30 for whom Pseudomonas aeruginosa was found positive (33.33%), all cultures were resistant to Penicillin and Oxacillin (100%), followed by Trimethoprim and Sulfamethoxazole (80%). The best performance was seen by Vancomycin (20%). No correlation was found in terms of age, gender, and type of disease (lymphoma or leukemia) for antibiotic resistance (p> 0.05). Conclusion: It seems that Penicillin, Oxacillin, Tetracycline, Sulfamethoxazole have significant resistance to Pseudomonas aeruginosa. Further research on Gentamicin, Ceftazidime, Ciprofloxacin, and especially Vancomycin is recommended for effective antibiotic prescriptions against Pseudomonas aeruginosa. | ||
| کلیدواژه‌ها | ||
| Drug Resistance؛ Hematopoietic Stem Cell Transplantation؛ Pseudomonas aeruginosa؛ Saliva | ||
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آمار تعداد مشاهده مقاله: 186 تعداد دریافت فایل اصل مقاله: 172 |
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