LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,450
تعداد دریافت فایل اصل مقاله11,291,235
Saipiyeva, Dana, Askarov, Manarbek, Jafari, Nazanin, Zhankina, Rano, Heath, Paul R., Kozina, Larissa, Boltanova, Alyona, Omarbekov, Ardak, Ilyassov, Nurbek, Tuganbekov, Turlybek, Mussin, Nadiar M., Kaliyev, Asset A., Sultangereyev, Yerlan, Rahmanifar, Farhad, Mahdipour, Mahdi, Bakhshalizadeh, Shabnam, Shirazi, Reza, Tanideh, Nader, Tamadon, Amin. (1403). Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis. سامانه مدیریت نشریات علمی, 49(9), 559-572. doi: 10.30476/ijms.2023.99613.3172
Dana Saipiyeva; Manarbek Askarov; Nazanin Jafari; Rano Zhankina; Paul R. Heath; Larissa Kozina; Alyona Boltanova; Ardak Omarbekov; Nurbek Ilyassov; Turlybek Tuganbekov; Nadiar M. Mussin; Asset A. Kaliyev; Yerlan Sultangereyev; Farhad Rahmanifar; Mahdi Mahdipour; Shabnam Bakhshalizadeh; Reza Shirazi; Nader Tanideh; Amin Tamadon. "Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis". سامانه مدیریت نشریات علمی, 49, 9, 1403, 559-572. doi: 10.30476/ijms.2023.99613.3172
Saipiyeva, Dana, Askarov, Manarbek, Jafari, Nazanin, Zhankina, Rano, Heath, Paul R., Kozina, Larissa, Boltanova, Alyona, Omarbekov, Ardak, Ilyassov, Nurbek, Tuganbekov, Turlybek, Mussin, Nadiar M., Kaliyev, Asset A., Sultangereyev, Yerlan, Rahmanifar, Farhad, Mahdipour, Mahdi, Bakhshalizadeh, Shabnam, Shirazi, Reza, Tanideh, Nader, Tamadon, Amin. (1403). 'Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis', سامانه مدیریت نشریات علمی, 49(9), pp. 559-572. doi: 10.30476/ijms.2023.99613.3172
Saipiyeva, Dana, Askarov, Manarbek, Jafari, Nazanin, Zhankina, Rano, Heath, Paul R., Kozina, Larissa, Boltanova, Alyona, Omarbekov, Ardak, Ilyassov, Nurbek, Tuganbekov, Turlybek, Mussin, Nadiar M., Kaliyev, Asset A., Sultangereyev, Yerlan, Rahmanifar, Farhad, Mahdipour, Mahdi, Bakhshalizadeh, Shabnam, Shirazi, Reza, Tanideh, Nader, Tamadon, Amin. Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis. سامانه مدیریت نشریات علمی, 1403; 49(9): 559-572. doi: 10.30476/ijms.2023.99613.3172

Bone Marrow and Peripheral Blood Mononuclear Cell Phenotype Changes after Cultivation and Autologous Infusion in Patients with Primary Biliary Cholangitis

Iranian Journal of Medical Sciences
مقاله 3، دوره 49، شماره 9، آذر 2024، صفحه 559-572    اصل مقاله (3.48 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.99613.3172
نویسندگان
Dana Saipiyeva1؛ Manarbek Askarov1؛ Nazanin Jafari2؛ Rano Zhankina3؛ Paul R. Heath4؛ Larissa Kozina5؛ Alyona Boltanova5؛ Ardak Omarbekov6؛ Nurbek Ilyassov7؛ Turlybek Tuganbekov6؛ Nadiar M. Mussin8؛ Asset A. Kaliyev8؛ Yerlan Sultangereyev8؛ Farhad Rahmanifar9؛ Mahdi Mahdipour10، 11؛ Shabnam Bakhshalizadeh12؛ Reza Shirazi13؛ Nader Tanideh2، 14، 15؛ Amin Tamadon* 16
1Cell Technologies, Transplantation and Research Department, National Scientific Medical Center, Astana, Kazakhstan
2PerciaVista R&D Co. Shiraz, Iran
3Department of Urology and Andrology, Astana Medical University, Astana, Kazakhstan
4Sheffield Institute for Translational Neuroscience (SITraN), Department of Neuroscience, University of Sheffield, 385 Glossop Road, Sheffield S10 2HQ, UK
5Clinical and Diagnostic Laboratory, National Scientific Medical Center, Astana, Kazakhstan
6Surgical Diseases, Angiosurgery and Plastic Surgery Department, Astana Medical University, Astana, Kazakhstan
7Department of Surgery, National Scientific Medical Center, Astana, Kazakhstan
8General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
9Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
10Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
11Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
12Reproductive Development, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
13Department of Anatomy, School of Biomedical Sciences, Medicine and Health, UNSW Sydney, Sydney, Australia
14Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
15Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
16Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Maresyev St, Aktobe, Kazakhstan
چکیده
Background: Primary biliary cholangitis (PBC) is a condition affecting the liver and immune system. In this study, the impact of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation on PBC patients was investigated. 
Methods: Sixteen eligible PBC patients participated at the National Scientific Medical Center in Astana, Kazakhstan, between 2017 and 2022, and BM-MNCs were harvested from their anterior iliac crest. After isolating and cultivating the BM-MNCs, they were infused back into the patient’s peripheral veins. Changes in BM-MNC and peripheral blood mononuclear cell (PB-MNC) phenotypes were assessed before and after a 24-hour cultivation period and 72 hours post-transplantation. We monitored liver function parameters over 6-month intervals and conducted flow cytometry analysis to assess CD markers on BM-MNCs before and after cultivation and PB-MNCs before and after transplantation. Statistical analysis included the Friedman test for liver parameters and the Wilcoxon signed-rank test for BM-MNC and PB-MNC comparisons.
Results: Our findings revealed significant reductions in liver function tests after multiple transplantations. Flow cytometry analysis before and after a 24-hour culture and autologous BM-MNC infusion revealed the expansion of specific cell populations, with significant increases in CD3+, CD4+, CD16+, CD20+, CD25+, CD34+, CD105+, CD73+, СD117+, and CD34+populations, while CD4+25+, CD34+105+, and CD4+FOXP3+ populations decreased. Interestingly, a contradictory finding was observed with a decrease in bone marrow CD34+105+ cell lines (P=0.03) alongside an increase in peripheral CD34+105+ population (P=0.03).
Conclusion: In summary, our study shows that BM-MNC transplantation in PBC patients leads to changes in immune cell populations and liver function. These findings suggest potential therapeutic applications of BM-MNC transplantation in managing PBC and offer insights into the dynamics of immune cells associated with this treatment approach.
کلیدواژه‌ها
Primary biliary cholangitis؛ Leukocytes, mononuclear؛ Bone marrow؛ Peripheral blood stem cells
سایر فایل های مرتبط با مقاله
مراجع
  1. Zhang Q, Liu Z, Wu S, Duan W, Chen S, Ou X, et al. Meta-Analysis of Antinuclear Antibodies in the Diagnosis of Antimitochondrial Antibody-Negative Primary Biliary Cholangitis. Gastroenterol Res Pract. 2019;2019:8959103. doi: 10.1155/2019/8959103. PubMed PMID: 31281353; PubMed Central PMCID: PMCPMC6590611.
  2. Boberg KM. The Clinical Burden of Biliary Disease: A Global Perspective. In: Hirschfield G, Adams D, Liaskou E, editors. Biliary Disease: From Science to Clinic. Cham: Springer International Publishing; 2017. p. 1-15. doi: 10.1007/978-3-319-50168-0_1.
  3. Marschall HU, Henriksson I, Lindberg S, Soderdahl F, Thuresson M, Wahlin S, et al. Incidence, prevalence, and outcome of primary biliary cholangitis in a nationwide Swedish population-based cohort. Sci Rep. 2019;9:11525. doi: 10.1038/s41598-019-47890-2. PubMed PMID: 31395896; PubMed Central PMCID: PMCPMC6687809.
  4. Kouchakian MR, Baghban N, Moniri SF, Baghban M, Bakhshalizadeh S, Najafzadeh V, et al. The Clinical Trials of Mesenchymal Stromal Cells Therapy. Stem Cells Int. 2021;2021:1634782. doi: 10.1155/2021/1634782. PubMed PMID: 34745268; PubMed Central PMCID: PMCPMC8566082.
  5. Kanate AS, Majhail NS, Savani BN, Bredeson C, Champlin RE, Crawford S, et al. Indications for Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: Guidelines from the American Society for Transplantation and Cellular Therapy. Biol Blood Marrow Transplant. 2020;26:1247-56. doi: 10.1016/j.bbmt.2020.03.002. PubMed PMID: 32165328.
  6. Shiota J, Samuelson LC, Razumilava N. Hepatobiliary Organoids and Their Applications for Studies of Liver Health and Disease: Are We There Yet? Hepatology. 2021;74:2251-63. doi: 10.1002/hep.31772. PubMed PMID: 33638203; PubMed Central PMCID: PMCPMC9067600.
  7. Lee C, Kim M, Han J, Yoon M, Jung Y. Mesenchymal Stem Cells Influence Activation of Hepatic Stellate Cells, and Constitute a Promising Therapy for Liver Fibrosis. Biomedicines. 2021;9. doi: 10.3390/biomedicines9111598. PubMed PMID: 34829827; PubMed Central PMCID: PMCPMC8615475.
  8. Boes KM, Durham AC. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System. Pathologic Basis of Veterinary Disease. 2017:724–804. doi: 10.1016/B978-0-323-35775-3.00013-8. PMCID: PMC7158316.
  9. Vina MF, Camozzi L. Bone Marrow Mononuclear Cells (BM-MNCs) and Human Autologous Bone Marrow Plasma Concentrate (HA-BMPC) for diabetic foot ulcer refractoratory to conventional treatment. A case report. Cytotherapy. 2020;22:S83. doi: 10.1016/j.jcyt.2020.03.137.
  10. Viswanathan S, Shi Y, Galipeau J, Krampera M, Leblanc K, Martin I, et al. Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT(R)) Mesenchymal Stromal Cell committee position statement on nomenclature. Cytotherapy. 2019;21:1019-24. doi: 10.1016/j.jcyt.2019.08.002. PubMed PMID: 31526643.
  11. Liu Y, Dong Y, Wu X, Xu X, Niu J. The assessment of mesenchymal stem cells therapy in acute on chronic liver failure and chronic liver disease: a systematic review and meta-analysis of randomized controlled clinical trials. Stem Cell Res Ther. 2022;13:204. doi: 10.1186/s13287-022-02882-4. PubMed PMID: 35578365; PubMed Central PMCID: PMCPMC9109309.
  12. Zeng J, Wu Y, Ren C, Bonanno J, Shen AH, Shea D, et al. Therapeutic base editing of human hematopoietic stem cells. Nat Med. 2020;26:535-41. doi: 10.1038/s41591-020-0790-y. PubMed PMID: 32284612; PubMed Central PMCID: PMCPMC7869435.
  13. Jurecic R. Hematopoietic Stem Cell Heterogeneity. Adv Exp Med Biol. 2019;1169:195-211. doi: 10.1007/978-3-030-24108-7_10. PubMed PMID: 31487025; PubMed Central PMCID: PMCPMC7409779.
  14. Weeda V, Mestrum SGC, Leers MPG. Flow Cytometric Identification of Hematopoietic and Leukemic Blast Cells for Tailored Clinical Follow-Up of Acute Myeloid Leukemia. Int J Mol Sci. 2022;23. doi: 10.3390/ijms231810529. PubMed PMID: 36142442; PubMed Central PMCID: PMCPMC9506284.
  15. Wu CX, Wang D, Cai Y, Luo AR, Sun H. Effect of Autologous Bone Marrow Stem Cell Therapy in Patients with Liver Cirrhosis: A Meta-analysis. J Clin Transl Hepatol. 2019;7:238-48. doi: 10.14218/JCTH.2019.00008. PubMed PMID: 31608216; PubMed Central PMCID: PMCPMC6783678.
  16. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973;60:646-9. doi: 10.1002/bjs.1800600817. PubMed PMID: 4541913.
  17. Kamath PS, Wiesner RH, Malinchoc M, Kremers W, Therneau TM, Kosberg CL, et al. A model to predict survival in patients with end-stage liver disease. Hepatology. 2001;33:464-70. doi: 10.1053/jhep.2001.22172. PubMed PMID: 11172350.
  18. Seet WT, Mat Afandi MA, Shamsuddin SA, Lokanathan Y, Ng MH, Maarof M. Current Good Manufacturing Practice (cGMP) Facility and Production of Stem Cell. In: Khan FA, editor. Stem Cell Production: Processes, Practices and Regulations. Singapore: Springer Singapore; 2022. p. 37-68. doi: 10.1007/978-981-16-7589-8_3.
  19. Seyfried AN, Maloney JM, MacNamara KC. Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress. Front Immunol. 2020;11:1499. doi: 10.3389/fimmu.2020.01499. PubMed PMID: 32849512; PubMed Central PMCID: PMCPMC7396643.
  20. Kajiume T, Kawahara Y, Yuge L, Kobayashi M. Osteoblastic adherence regulates hematopoietic stem cell self-renewal and differentiation: a conceptional in vitro and in vivo study. Stem Cell Investig. 2021;8:21. doi: 10.21037/sci-2021-019. PubMed PMID: 34815976; PubMed Central PMCID: PMCPMC8578737.
  21. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harb Perspect Biol. 2011;3. doi: 10.1101/cshperspect.a005058. PubMed PMID: 21917992; PubMed Central PMCID: PMCPMC3225943.
  22. Florez MA, Matatall KA, Jeong Y, Ortinau L, Shafer PW, Lynch AM, et al. Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2. Cell Rep. 2020;33:108530. doi: 10.1016/j.celrep.2020.108530. PubMed PMID: 33357430; PubMed Central PMCID: PMCPMC7816211.
  23. Jarczak D, Nierhaus A. Cytokine Storm-Definition, Causes, and Implications. Int J Mol Sci. 2022;23. doi: 10.3390/ijms231911740. PubMed PMID: 36233040; PubMed Central PMCID: PMCPMC9570384.
  24. Perez LM, de Lucas B, Galvez BG. Unhealthy Stem Cells: When Health Conditions Upset Stem Cell Properties. Cell Physiol Biochem. 2018;46:1999-2016. doi: 10.1159/000489440. PubMed PMID: 29723858.
  25. Demerdash Y, Kain B, Essers MAG, King KY. Yin and Yang: The dual effects of interferons on hematopoiesis. Exp Hematol. 2021;96:1-12. doi: 10.1016/j.exphem.2021.02.002. PubMed PMID: 33571568; PubMed Central PMCID: PMCPMC8919039.
  26. Sezaki M, Hayashi Y, Wang Y, Johansson A, Umemoto T, Takizawa H. Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation. Front Immunol. 2020;11:585367. doi: 10.3389/fimmu.2020.585367. PubMed PMID: 33329562; PubMed Central PMCID: PMCPMC7732516.
  27. Song N, Scholtemeijer M, Shah K. Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential. Trends Pharmacol Sci. 2020;41:653-64. doi: 10.1016/j.tips.2020.06.009. PubMed PMID: 32709406; PubMed Central PMCID: PMCPMC7751844.
  28. Jiang W, Xu J. Immune modulation by mesenchymal stem cells. Cell Prolif. 2020;53:e12712. doi: 10.1111/cpr.12712. PubMed PMID: 31730279; PubMed Central PMCID: PMCPMC6985662.
  29. Hydes TJ, Blunt MD, Naftel J, Vallejo AF, Seumois G, Wang A, et al. Constitutive Activation of Natural Killer Cells in Primary Biliary Cholangitis. Front Immunol. 2019;10:2633. doi: 10.3389/fimmu.2019.02633. PubMed PMID: 31803181; PubMed Central PMCID: PMCPMC6874097.
  30. Katsumi T, Guicciardi ME, Azad A, Bronk SF, Krishnan A, Gores GJ. Activated cholangiocytes release macrophage-polarizing extracellular vesicles bearing the DAMP S100A11. Am J Physiol Cell Physiol. 2019;317:C788-C99. doi: 10.1152/ajpcell.00250.2019. PubMed PMID: 31365294; PubMed Central PMCID: PMCPMC6851002.
  31. Tsuda M, Moritoki Y, Lian ZX, Zhang W, Yoshida K, Wakabayashi K, et al. Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid. Hepatology. 2012;55:512-21. doi: 10.1002/hep.24748. PubMed PMID: 22006563.
  32. Dhirapong A, Lleo A, Yang GX, Tsuneyama K, Dunn R, Kehry M, et al. B cell depletion therapy exacerbates murine primary biliary cirrhosis. Hepatology. 2011;53:527-35. doi: 10.1002/hep.24044. PubMed PMID: 21274873; PubMed Central PMCID: PMCPMC3058242.
  33. Tajiri K, Tsuneyama K, Miyazono T, Kawai K, Minemura M, Sugiyama T. A case of primary biliary cirrhosis that progressed rapidly after treatment involving rituximab. Case Rep Gastroenterol. 2013;7:195-201. doi: 10.1159/000351173. PubMed PMID: 23687488; PubMed Central PMCID: PMCPMC3656669.
  34. Chen YY, Jeffery HC, Hunter S, Bhogal R, Birtwistle J, Braitch MK, et al. Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis. Hepatology. 2016;64:138-50. doi: 10.1002/hep.28517. PubMed PMID: 26928938; PubMed C
آمار
تعداد مشاهده مقاله: 512
تعداد دریافت فایل اصل مقاله: 434


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب