LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,089
تعداد مقالات10,007
تعداد مشاهده مقاله26,716,495
تعداد دریافت فایل اصل مقاله7,336,083
Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. (1403). High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study. سامانه مدیریت نشریات علمی, 49(4), 247-258. doi: 10.30476/ijms.2023.97708.2951
Sepehr Shahriarirad; Naeimehossadat Asmarian; Reza Shahriarirad; Mohsen Moghadami; Mehrdad Askarian; Leila Hashemizadeh Fard Haghighi; Parisa Javadi; Golnar Sabetian. "High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study". سامانه مدیریت نشریات علمی, 49, 4, 1403, 247-258. doi: 10.30476/ijms.2023.97708.2951
Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. (1403). 'High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study', سامانه مدیریت نشریات علمی, 49(4), pp. 247-258. doi: 10.30476/ijms.2023.97708.2951
Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study. سامانه مدیریت نشریات علمی, 1403; 49(4): 247-258. doi: 10.30476/ijms.2023.97708.2951

High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study

Iranian Journal of Medical Sciences
مقاله 5، دوره 49، شماره 4، تیر 2024، صفحه 247-258    اصل مقاله (2.11 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.97708.2951
نویسندگان
Sepehr Shahriarirad1، 2؛ Naeimehossadat Asmarian3؛ Reza Shahriarirad1؛ Mohsen Moghadami4؛ Mehrdad Askarian5؛ Leila Hashemizadeh Fard Haghighi6؛ Parisa Javadi7؛ Golnar Sabetian* 8
1Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Vice Chancellor for Health Affairs Center of Disease Control (CDC), Shiraz University of Medical Sciences, Shiraz, Iran
7Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
8Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Even though a few years have passed since the coronavirus disease 2019 (COVID-19) outbreak, information regarding certain aspects of the disease, such as post-infection immunity, is still quite limited. This study aimed to evaluate post-infection protection and COVID-19 features among healthcare workers (HCWs), during three successive surges, as well as the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection, reactivation, re-positivity, and severity.
Methods: This cross-sectional population-level observational study was conducted from 20 April 2020 to 18 February 2021. The study population included all HCWs in public or private hospitals in Fars Province, Southern Iran. The infection rate was computed as the number of individuals with positive polymerase chain reaction (PCR) tests divided by the total number of person-days at risk. The re-infection was evaluated after 90 days. 
Results: A total of 30,546 PCR tests were performed among HCWs, of which 13,749 (61.94% of total HCWs) were positive. Considering the applied 90-day threshold, there were 44 (31.2%) cases of reactivation and relapse, and 97 (68.8% of infected and 1.81% of total HCWs) cases of reinfection among 141 (2.64%) diagnosed cases who experienced a second episode of COVID-19. 
There was no significant difference in symptoms (P=0.65) or the necessity for ICU admission (P=0.25). The estimated protection against repeated infection after a previous SARS-CoV-2 infection was 94.8% (95% CI=93.6-95.7).
Conclusion: SARS-CoV-2 re-positivity, relapse, and reinfection were rare in the HCW population. After the first episode of infection, an estimated 94.8% protection against recurring infections was achieved.
کلیدواژه‌ها
COVID-19؛ Healthcare worker؛ Polymerase chain reaction؛ Reinfection؛ Relapse
سایر فایل های مرتبط با مقاله
مراجع
  1. Lumley SF, O’Donnell D, Stoesser NE, Matthews PC, Howarth A, Hatch SB, et al. Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers. N Engl J Med. 2021;384:533-40. doi: 10.1056/NEJMoa2034545. PubMed PMID: 33369366; PubMed Central PMCID: PMCPMC7781098.
  2. Plotkin SA. Vaccines: correlates of vaccine-induced immunity. Clin Infect Dis. 2008;47:401-9. doi: 10.1086/589862. PubMed PMID: 18558875.
  3. Shahriarirad R, Sarkari B. COVID-19: clinical or laboratory diagnosis? A matter of debate. Trop Doct. 2021;51:131-2. doi: 10.1177/0049475520945446. PubMed PMID: 32762302.
  4. Gupta V, Bhoyar RC, Jain A, Srivastava S, Upadhayay R, Imran M, et al. Asymptomatic Reinfection in 2 Healthcare Workers From India With Genetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2. Clin Infect Dis. 2021;73:e2823-e5. doi: 10.1093/cid/ciaa1451. PubMed PMID: 32964927; PubMed Central PMCID: PMCPMC7543380.
  5. Lee JS, Kim SY, Kim TS, Hong KH, Ryoo NH, Lee J, et al. Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection After Recovery from Mild Coronavirus Disease 2019. Clin Infect Dis. 2021;73:e3002-e8. doi: 10.1093/cid/ciaa1421. PubMed PMID: 33219681; PubMed Central PMCID: PMCPMC7890673.
  6. To KK, Hung IF, Ip JD, Chu AW, Chan WM, Tam AR, et al. Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing. Clin Infect Dis. 2021;73:e2946-e51. doi: 10.1093/cid/ciaa1275. PubMed PMID: 32840608; PubMed Central PMCID: PMCPMC7499500.
  7. Tillett RL, Sevinsky JR, Hartley PD, Kerwin H, Crawford N, Gorzalski A, et al. Genomic evidence for reinfection with SARS-CoV-2: a case study. Lancet Infect Dis. 2021;21:52-8. doi: 10.1016/S1473-3099(20)30764-7. PubMed PMID: 33058797; PubMed Central PMCID: PMCPMC7550103.
  8. Hall V, Foulkes S, Charlett A, Atti A, Monk EJ, Simmons R, et al. Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020. Medrxiv. 2021:2021.01. 13.21249642. doi: 10.1101/2021.01.13.21249642.
  9. Shreffler J, Petrey J, Huecker M. The Impact of COVID-19 on Healthcare Worker Wellness: A Scoping Review. West J Emerg Med. 2020;21:1059-66. doi: 10.5811/westjem.2020.7.48684. PubMed PMID: 32970555; PubMed Central PMCID: PMCPMC7514392.
  10. Styra R, Hawryluck L, Mc Geer A, Dimas M, Sheen J, Giacobbe P, et al. Surviving SARS and living through COVID-19: Healthcare worker mental health outcomes and insights for coping. PLoS One. 2021;16:e0258893. doi: 10.1371/journal.pone.0258893. PubMed PMID: 34758047; PubMed Central PMCID: PMCPMC8580217.
  11. Young KP, Kolcz DL, Ferrand J, O’Sullivan DM, Robinson K. Healthcare Worker Mental Health and Wellbeing During COVID-19: Mid-Pandemic Survey Results. Front Psychol. 2022;13:924913. doi: 10.3389/fpsyg.2022.924913. PubMed PMID: 35911017; PubMed Central PMCID: PMCPMC9333086.
  12. Sabetian G, Moghadami M, Hashemizadeh Fard Haghighi L, Shahriarirad R, Fallahi MJ, Asmarian N, et al. COVID-19 infection among healthcare workers: a cross-sectional study in southwest Iran. Virol J. 2021;18:58. doi: 10.1186/s12985-021-01532-0. PubMed PMID: 33731169; PubMed Central PMCID: PMCPMC7968574.
  13. Shahriarirad R, Khodamoradi Z, Erfani A, Hosseinpour H, Ranjbar K, Emami Y, et al. Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran. BMC Infect Dis. 2020;20:427. doi: 10.1186/s12879-020-05128-x. PubMed PMID: 32552751; PubMed Central PMCID: PMCPMC7301075.
  14. Organization WH. Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance, 2 March 2020. Genova: World Health Organization; 2020.
  15. Coronavirus disease (COVID-19) technical guidance: Laboratory testing for 2019-nCoV in humans 31 March 2020. Genova: World Health Organization, 2020.
  16. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DK, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25. doi: 10.2807/1560-7917.ES.2020.25.3.2000045. PubMed PMID: 31992387; PubMed Central PMCID: PMCPMC6988269.
  17. Shafiekhani M, Niknam T, Tara SA, Mardani P, Mirzad Jahromi K, Jafarian S, et al. COVID-19 versus applied infection control policies in a Major Transplant Center in Iran. Cost Eff Resour Alloc. 2023;21:17. doi: 10.1186/s12962-023-00427-x. PubMed PMID: 36849978; PubMed Central PMCID: PMCPMC9969367.
  18. Yahav D, Yelin D, Eckerle I, Eberhardt CS, Wang J, Cao B, et al. Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. Clin Microbiol Infect. 2021;27:315-8. doi: 10.1016/j.cmi.2020.11.028. PubMed PMID: 33285276; PubMed Central PMCID: PMCPMC7718119.
  19. Control CfD, Prevention. Duration of isolation and precautions for adults with COVID-19. Atlanta: Centers for Disease Control Prevention; 2020.
  20. Hansen CH, Michlmayr D, Gubbels SM, Molbak K, Ethelberg S. Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study. Lancet. 2021;397:1204-12. doi: 10.1016/S0140-6736(21)00575-4. PubMed PMID: 33743221; PubMed Central PMCID: PMCPMC7969130.
  21. Quigley AL, Stone H, Nguyen PY, Chughtai AA, MacIntyre CR. Estimating the burden of COVID-19 on the Australian healthcare workers and health system during the first six months of the pandemic. Int J Nurs Stud. 2021;114:103811. doi: 10.1016/j.ijnurstu.2020.103811. PubMed PMID: 33352440; PubMed Central PMCID: PMCPMC7598370.
  22. Laursen J, Petersen J, Didriksen M, Iversen K, Ullum H. Prevalence of SARS-CoV-2 IgG/IgM Antibodies among Danish and Swedish Falck Emergency and Non-Emergency Healthcare Workers. Int J Environ Res Public Health. 2021;18. doi: 10.3390/ijerph18030923. PubMed PMID: 33494409; PubMed Central PMCID: PMCPMC7908436.
  23. Rostami A, Sepidarkish M, Leeflang MMG, Riahi SM, Nourollahpour Shiadeh M, Esfandyari S, et al. SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis. Clin Microbiol Infect. 2021;27:331-40. doi: 10.1016/j.cmi.2020.10.020. PubMed PMID: 33228974; PubMed Central PMCID: PMCPMC7584920.
  24. Poustchi H, Darvishian M, Mohammadi Z, Shayanrad A, Delavari A, Bahadorimonfared A, et al. SARS-CoV-2 antibody seroprevalence in the general population and high-risk occupational groups across 18 cities in Iran: a population-based cross-sectional study. Lancet Infect Dis. 2021;21:473-81. doi: 10.1016/S1473-3099(20)30858-6. PubMed PMID: 33338441; PubMed Central PMCID: PMCPMC7833828.
  25. Rudberg AS, Havervall S, Manberg A, Jernbom Falk A, Aguilera K, Ng H, et al. SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden. Nat Commun. 2020;11:5064. doi: 10.1038/s41467-020-18848-0. PubMed PMID: 33033249; PubMed Central PMCID: PMCPMC7544689.
  26. Galanis P, Vraka I, Fragkou D, Bilali A, Kaitelidou D. Seroprevalence of SARS-CoV-2 antibodies and associated factors in healthcare workers: a systematic review and meta-analysis. J Hosp Infect. 2021;108:120-34. doi: 10.1016/j.jhin.2020.11.008. PubMed PMID: 33212126; PubMed Central PMCID: PMCPMC7668234.
  27. Mitchell R, Ogunremi T, Astrakianakis G, Bryce E, Gervais R, Gravel D, et al. Impact of the 2009 influenza A (H1N1) pandemic on Canadian health care workers: a survey on vaccination, illness, absenteeism, and personal protective equipment. Am J Infect Control. 2012;40:611-6. doi: 10.1016/j.ajic.2012.01.011. PubMed PMID: 22575285.
  28. Iversen K, Bundgaard H, Hasselbalch RB, Kristensen JH, Nielsen PB, Pries-Heje M, et al. Risk of COVID-19 in health-care workers in Denmark: an observational cohort study. Lancet Infect Dis. 2020;20:1401-8. doi: 10.1016/S1473-3099(20)30589-2. PubMed PMID: 32758438; PubMed Central PMCID: PMCPMC7398038.
  29. Erfani A, Shahriarirad R, Ranjbar K, Mirahmadizadeh A, Moghadami M. Knowledge, attitude, and practice toward the novel coronavirus (COVID-19) outbreak: a population-based survey in Iran. Journal of Health Sciences & Surveillance System. 2023;11:578-91.
  30. Harvey RA, Rassen JA, Kabelac CA, Turenne W, Leonard S, Klesh R, et al. Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection. JAMA Intern Med. 2021;181:672-9. doi: 10.1001/jamainternmed.2021.0366. PubMed PMID: 33625463; PubMed Central PMCID: PMCPMC7905701.
  31. Abu-Raddad LJ, Chemaitelly H, Coyle P, Malek JA, Ahmed AA, Mohamoud YA, et al. SARS-CoV-2 reinfection in a cohort of 43,000 antibody-positive individuals followed for up to 35 weeks. MedRxiv. 2021. doi: 10.1101/2021.01.15.21249731.
  32. Larson D, Brodniak SL, Voegtly LJ, Cer RZ, Glang LA, Malagon FJ, et al. A Case of Early Reinfection With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2021;73:e2827-e8. doi: 10.1093/cid/ciaa1436. PubMed PMID: 32949240; PubMed Central PMCID: PMCPMC7543357.
  33. Iwasaki A. What reinfections mean for COVID-19. Lancet Infect Dis. 2021;21:3-5. doi: 10.1016/S1473-3099(20)30783-0. PubMed PMID: 33058796; PubMed Central PMCID: PMCPMC7550040.
آمار
تعداد مشاهده مقاله: 123
تعداد دریافت فایل اصل مقاله: 105


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب