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Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. (1403). High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study. سامانه مدیریت نشریات علمی, 49(4), 247-258. doi: 10.30476/ijms.2023.97708.2951
Sepehr Shahriarirad; Naeimehossadat Asmarian; Reza Shahriarirad; Mohsen Moghadami; Mehrdad Askarian; Leila Hashemizadeh Fard Haghighi; Parisa Javadi; Golnar Sabetian. "High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study". سامانه مدیریت نشریات علمی, 49, 4, 1403, 247-258. doi: 10.30476/ijms.2023.97708.2951
Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. (1403). 'High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study', سامانه مدیریت نشریات علمی, 49(4), pp. 247-258. doi: 10.30476/ijms.2023.97708.2951
Shahriarirad, Sepehr, Asmarian, Naeimehossadat, Shahriarirad, Reza, Moghadami, Mohsen, Askarian, Mehrdad, Hashemizadeh Fard Haghighi, Leila, Javadi, Parisa, Sabetian, Golnar. High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study. سامانه مدیریت نشریات علمی, 1403; 49(4): 247-258. doi: 10.30476/ijms.2023.97708.2951

High Post-Infection Protection after COVID-19 among Healthcare Workers: A Population-Level Observational Study

Iranian Journal of Medical Sciences
مقاله 5، دوره 49، شماره 4، تیر 2024، صفحه 247-258    اصل مقاله (2.11 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.97708.2951
نویسندگان
Sepehr Shahriarirad1، 2؛ Naeimehossadat Asmarian3؛ Reza Shahriarirad1؛ Mohsen Moghadami4؛ Mehrdad Askarian5؛ Leila Hashemizadeh Fard Haghighi6؛ Parisa Javadi7؛ Golnar Sabetian* 8
1Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Vice Chancellor for Health Affairs Center of Disease Control (CDC), Shiraz University of Medical Sciences, Shiraz, Iran
7Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
8Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Even though a few years have passed since the coronavirus disease 2019 (COVID-19) outbreak, information regarding certain aspects of the disease, such as post-infection immunity, is still quite limited. This study aimed to evaluate post-infection protection and COVID-19 features among healthcare workers (HCWs), during three successive surges, as well as the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection, reactivation, re-positivity, and severity.
Methods: This cross-sectional population-level observational study was conducted from 20 April 2020 to 18 February 2021. The study population included all HCWs in public or private hospitals in Fars Province, Southern Iran. The infection rate was computed as the number of individuals with positive polymerase chain reaction (PCR) tests divided by the total number of person-days at risk. The re-infection was evaluated after 90 days. 
Results: A total of 30,546 PCR tests were performed among HCWs, of which 13,749 (61.94% of total HCWs) were positive. Considering the applied 90-day threshold, there were 44 (31.2%) cases of reactivation and relapse, and 97 (68.8% of infected and 1.81% of total HCWs) cases of reinfection among 141 (2.64%) diagnosed cases who experienced a second episode of COVID-19. 
There was no significant difference in symptoms (P=0.65) or the necessity for ICU admission (P=0.25). The estimated protection against repeated infection after a previous SARS-CoV-2 infection was 94.8% (95% CI=93.6-95.7).
Conclusion: SARS-CoV-2 re-positivity, relapse, and reinfection were rare in the HCW population. After the first episode of infection, an estimated 94.8% protection against recurring infections was achieved.
کلیدواژه‌ها
COVID-19؛ Healthcare worker؛ Polymerase chain reaction؛ Reinfection؛ Relapse
سایر فایل های مرتبط با مقاله
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