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Abnormal Changes in IL-13 and IL-17A Serum Levels in Children with Adenovirus Pneumonia and their Diagnostic Value | ||
| Iranian Journal of Immunology | ||
| دوره 21، شماره 1، خرداد 2024، صفحه 81-88 اصل مقاله (685.45 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2024.99509.2648 | ||
| نویسندگان | ||
| Jianbo Jiang* 1؛ Lili Sun2؛ Meixia Huang3 | ||
| 1Pediatric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China. | ||
| 2Obstetric Department, Hangzhou Fuyang Women and Children Hospital, Zhejiang Province, 311400, China. | ||
| 3Pediatric Department, Children’s Hospital of Zhejiang University School of Medicine, Zhejiang Province, 310057, China. | ||
| چکیده | ||
| Background: Human adenovirus (HAdV) is an enveloped icosahedral DNA virus. HAdV infection can lead to immune system damage, resulting in decreased numbers and compromised function of T cells and B cells. It can also cause an imbalanced Th1/Th2 ratio and dysregulation of pro-inflammatory and anti-inflammatory cytokines. Objective: To investigate the serum levels of interleukin (IL)-13 and IL-17A in children with HAdV pneumonia. Methods: Pediatric patients diagnosed with HAdV pneumonia were divided into a non-severe group or a severe group based on the severity of their condition. Patients in the severe group were further classified into good and poor prognosis subgroups. We collected 2-2.5 mL of venous blood from each patient, which was then centrifuged. Using an ELISA detection kit, we determined the concentrations of IL-13 and IL-17A. Results: Patients with a severe condition exhibited significantly higher serum concentrations of IL-13 and IL-17A than the non-severe cases. Out of 50 severe cases, 32 had good prognoses, while 18 cases showed poor prognoses. Patients with poor prognoses showed significantly higher serum concentrations of IL-13 compared to those with good prognoses. Conclusion: Serum concentrations of IL-13 and IL-17A are potential diagnostic markers for pediatric patients with severe HAdV pneumonia. Additionally, they demonstrate good predictive value for a poor prognosis in severe pneumonia cases. | ||
| کلیدواژه‌ها | ||
| Adenovirus؛ Interleukin-13؛ Interleukin-17A؛ Pediatrics؛ Severe Pneumonia | ||
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آمار تعداد مشاهده مقاله: 481 تعداد دریافت فایل اصل مقاله: 333 |
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