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Hosseini, Sare, Arastouei, Soudeh, Afzalaghaei, Monavar, Zarei, Elham, Ahmadi, Seyed Parham. (1403). Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran. سامانه مدیریت نشریات علمی, 15(3), 234-241. doi: 10.30476/mejc.2023.98999.1924
Sare Hosseini; Soudeh Arastouei; Monavar Afzalaghaei; Elham Zarei; Seyed Parham Ahmadi. "Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran". سامانه مدیریت نشریات علمی, 15, 3, 1403, 234-241. doi: 10.30476/mejc.2023.98999.1924
Hosseini, Sare, Arastouei, Soudeh, Afzalaghaei, Monavar, Zarei, Elham, Ahmadi, Seyed Parham. (1403). 'Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran', سامانه مدیریت نشریات علمی, 15(3), pp. 234-241. doi: 10.30476/mejc.2023.98999.1924
Hosseini, Sare, Arastouei, Soudeh, Afzalaghaei, Monavar, Zarei, Elham, Ahmadi, Seyed Parham. Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran. سامانه مدیریت نشریات علمی, 1403; 15(3): 234-241. doi: 10.30476/mejc.2023.98999.1924

Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran

Middle East Journal of Cancer
مقاله 8، دوره 15، شماره 3 - شماره پیاپی 59، مهر 2024، صفحه 234-241    اصل مقاله (122.7 K)
نوع مقاله: Middle East Special Report
شناسه دیجیتال (DOI): 10.30476/mejc.2023.98999.1924
نویسندگان
Sare Hosseini1؛ Soudeh Arastouei* 1؛ Monavar Afzalaghaei2؛ Elham Zarei1؛ Seyed Parham Ahmadi3
1Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Epidemiology and Biostatistics, School of Health, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background: Uterine sarcomas (US) represent a rare and heterogeneous spectrum of tumors characterized by diverse clinical behaviors and tumor responses. This study aims to assess patient and tumor characteristics and oncologic outcomes.
Method: This historical cohort study encompassed all patients with histologically confirmed diagnoses of the US who were referred to two oncology centers affiliated with Mashhad University of Medical Sciences (Iran) between March 2011 and April 2020. Data analyses were conducted using STATA version 14.02. Survival estimation was carried out utilizing the Kaplan-Meier method. The significance level was established at 0.05.
Results: A total of 33 patients were included in this study, comprising 23 with US and 10 with carcinosarcoma (CS). The mean age was 49.3 years for CS and 62.4 years for US (P = 0.0001). Nearly all patients were overweight, with a mean body mass index of 27.1 (confidence interval: 25.6-28.7). The majority of patients were diagnosed at an early stage. The Federation of Gynecology and Obstetrics (FIGO) stage, patient's anemia, and surgical resection were identified as significant prognostic factors. The median overall survival was 50.88 ± 5.7 months. The survival rates at 2, 3, and 5 years were 75%, 56%, and 41%, respectively. No significant difference was observed between CS and US regarding overall and disease-free survival.
Conclusion: Despite the typical early-stage diagnosis for US patients, the 5-year survival rate remains low. This study underscores the pivotal role of FIGO stage, tumor size, and surgical resection as vital prognostic factors for survival.

تازه های تحقیق

Sare Hosseini (PubMed)

کلیدواژه‌ها
Uterine neoplasms؛ Carcinosarcoma؛ Survival analysis؛ Prognosis
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