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AL-Hasnawi, Sawsan M. Jabbar, Noori, Mays Amer, AL-Haidari, Amer Fadhil, Hussain, Munther J.. (1403). Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children. سامانه مدیریت نشریات علمی, 49(4), 229-236. doi: 10.30476/ijms.2023.97556.2934
Sawsan M. Jabbar AL-Hasnawi; Mays Amer Noori; Amer Fadhil AL-Haidari; Munther J. Hussain. "Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children". سامانه مدیریت نشریات علمی, 49, 4, 1403, 229-236. doi: 10.30476/ijms.2023.97556.2934
AL-Hasnawi, Sawsan M. Jabbar, Noori, Mays Amer, AL-Haidari, Amer Fadhil, Hussain, Munther J.. (1403). 'Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children', سامانه مدیریت نشریات علمی, 49(4), pp. 229-236. doi: 10.30476/ijms.2023.97556.2934
AL-Hasnawi, Sawsan M. Jabbar, Noori, Mays Amer, AL-Haidari, Amer Fadhil, Hussain, Munther J.. Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children. سامانه مدیریت نشریات علمی, 1403; 49(4): 229-236. doi: 10.30476/ijms.2023.97556.2934

Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children

Iranian Journal of Medical Sciences
مقاله 3، دوره 49، شماره 4، تیر 2024، صفحه 229-236    اصل مقاله (472.37 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.97556.2934
نویسندگان
Sawsan M. Jabbar AL-Hasnawi* 1؛ Mays Amer Noori2؛ Amer Fadhil AL-Haidari3؛ Munther J. Hussain4
1Department of Medical Microbiology, College of Medicine, Kerbala University, Karbala, Iraq
2AL-Hasan Teaching Hospital, Karbala, Iraq
3Department of Internal Medicine, College of Medicine, Kerbala University, Karbala, Iraq
4Institute of Liver Studies, King’s College London, School of Medicine, King’s College Hospital, London, SE5 9RS, UK
چکیده
Background: Attention deficit hyperactivity disorder (ADHD) is a widespread neuropsychiatric disorder in both children and adolescents, which is associated with social isolation and poor academic performance. Complement proteins are regarded as a major player in inflammation and disease development for several neuropsychiatric diseases such as schizophrenia and bipolar diseases. As clarified by previous data, increased levels of complement molecules and other immunological markers as cytokines were demonstrated in these disorders. Limited studies have investigated complement proteins particularly terminal complement complex or membrane attack complex (C5b-9) among ADHD patients. The present research aims to elucidate the association between C5b-9 complex protein and ADHD.
Methods: This is a cross-sectional study. Sera were collected from Al-Hussain Teaching Medical City in Holy Karbala, Iraq, during 2019-2020. Sera were tested for C5-b9 using commercial kits by enzyme-linked immunosorbent assay (ELISA). 
Results: In 90 participants included in the study, a significant increment in C5b-9 levels among ADHD patients (P=0.019) was observed. Patients with positive C5b-9 levels had a 2.76 times higher risk of developing ADHD than control subjects. The diagnostic utility for C5b-9 was statistically significant with 71.11% sensitivity, 55.6% specificity, and a high negative predictive value (97.3%).
Conclusion: The study concluded elevation of the C5b-9 terminal complements complex levels in ADHD patients, which could point to the association of complement proteins as inflammatory markers with the ADHD disease process.
کلیدواژه‌ها
Attention deficit disorder with hyperactivity؛ Complement membrane attack complex؛ Enzyme-linked immunosorbent assay
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