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Lubis, Siska Mayasari, Soesanti, Frida, Hidayati, Eka Laksmi, AAP, Bambang Tridjaja. (1403). Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension. سامانه مدیریت نشریات علمی, 49(6), 377-383. doi: 10.30476/ijms.2023.98508.3058
Siska Mayasari Lubis; Frida Soesanti; Eka Laksmi Hidayati; Bambang Tridjaja AAP. "Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension". سامانه مدیریت نشریات علمی, 49, 6, 1403, 377-383. doi: 10.30476/ijms.2023.98508.3058
Lubis, Siska Mayasari, Soesanti, Frida, Hidayati, Eka Laksmi, AAP, Bambang Tridjaja. (1403). 'Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension', سامانه مدیریت نشریات علمی, 49(6), pp. 377-383. doi: 10.30476/ijms.2023.98508.3058
Lubis, Siska Mayasari, Soesanti, Frida, Hidayati, Eka Laksmi, AAP, Bambang Tridjaja. Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension. سامانه مدیریت نشریات علمی, 1403; 49(6): 377-383. doi: 10.30476/ijms.2023.98508.3058

Congenital Adrenal Hyperplasia in Children: The Relationship between Plasma Renin Activity and Hypertension

Iranian Journal of Medical Sciences
مقاله 5، دوره 49، شماره 6، شهریور 2024، صفحه 377-383    اصل مقاله (326.43 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.98508.3058
نویسندگان
Siska Mayasari Lubis* 1؛ Frida Soesanti2؛ Eka Laksmi Hidayati2؛ Bambang Tridjaja AAP2
1Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia
2Department of Child Health, Faculty of Medicine, Universitas Indonesia Jakarta, Indonesia
چکیده
Background: Children with Congenital Adrenal Hyperplasia (CAH) have a higher chance of hypertension. The likelihood of hypertension is higher in CAH children who get fludrocortisone medication and have an over-suppression. Plasma renin activity (PRA) is a sensitive indicator when the fludrocortisone dose is insufficient. The objective of this study is to assess the relationship between plasma renin activity with hypertension in 21-hydroxylase-deficient (21-OHD) CAH children. 
Methods: This cross-sectional observational analytical study was conducted in 2019 at the Pediatric Endocrinology Outpatient Clinic in Dr. Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia. The subjects were 21-OHD CAH children, aged >6 months to 18 years who had already taken hydrocortisone with or without fludrocortisone for at least 6 months, and were divided into hypertension and non-hypertension groups. The subjects were selected by a consecutive sampling method. Data was analyzed using SPSS software (version 23.0) with unpaired t test analysis and multiple logistic regression test. Statistical significance was achieved if P<0.05.
Results: Forty 21-OHD CAH patients were included, and 20 subjects (50%) had hypertension. A higher incidence of hypertension was found in salt-wasting CAH than in simple virilizing types (59.3% vs 30.8%). There was a significant mean difference in PRA levels between hypertension and non-hypertension groups in salt-wasting patients (P=0.016). A significant difference between the last dose of hydrocortisone with the number of hypertension patients in salt-wasting patients (P=0.032) was found, and low PRA levels showed a 1.09 times higher risk of hypertension. 
Conclusion: Children with salt-wasting CAH with low PRA levels had a higher risk of getting hypertension.
کلیدواژه‌ها
Adrenal hyperplasia, congenital؛ Hypertension؛ Hydrocortisone
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مراجع
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