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Ahmadi-Vasmehjani, Azam, SeyedHosseini, Seyed Mostafa, Khayyatzadeh, Sayyed Saeid, Madadizadeh, Farzan, Mazaheri-Naeini, Mahta, Yavari, Mahdie, Darabi, Zahra, Beigrezaei, Sara, Taftian, Marzieh, Arabi, Vahid, Motallaei, Maryam, Salehi-Abargouei, Amin, Nadjarzadeh, Azadeh. (1403). Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 49(4), 219-228. doi: 10.30476/ijms.2023.98201.3012
Azam Ahmadi-Vasmehjani; Seyed Mostafa SeyedHosseini; Sayyed Saeid Khayyatzadeh; Farzan Madadizadeh; Mahta Mazaheri-Naeini; Mahdie Yavari; Zahra Darabi; Sara Beigrezaei; Marzieh Taftian; Vahid Arabi; Maryam Motallaei; Amin Salehi-Abargouei; Azadeh Nadjarzadeh. "Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study". سامانه مدیریت نشریات علمی, 49, 4, 1403, 219-228. doi: 10.30476/ijms.2023.98201.3012
Ahmadi-Vasmehjani, Azam, SeyedHosseini, Seyed Mostafa, Khayyatzadeh, Sayyed Saeid, Madadizadeh, Farzan, Mazaheri-Naeini, Mahta, Yavari, Mahdie, Darabi, Zahra, Beigrezaei, Sara, Taftian, Marzieh, Arabi, Vahid, Motallaei, Maryam, Salehi-Abargouei, Amin, Nadjarzadeh, Azadeh. (1403). 'Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study', سامانه مدیریت نشریات علمی, 49(4), pp. 219-228. doi: 10.30476/ijms.2023.98201.3012
Ahmadi-Vasmehjani, Azam, SeyedHosseini, Seyed Mostafa, Khayyatzadeh, Sayyed Saeid, Madadizadeh, Farzan, Mazaheri-Naeini, Mahta, Yavari, Mahdie, Darabi, Zahra, Beigrezaei, Sara, Taftian, Marzieh, Arabi, Vahid, Motallaei, Maryam, Salehi-Abargouei, Amin, Nadjarzadeh, Azadeh. Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study. سامانه مدیریت نشریات علمی, 1403; 49(4): 219-228. doi: 10.30476/ijms.2023.98201.3012

Cholesterol Ester Transfer Protein Taq1B Polymorphism and Its Association with Cardiovascular Risk Factors in Patients Undergoing Angiography in Yazd, Eastern Iran: A Cross-Sectional Study

Iranian Journal of Medical Sciences
مقاله 2، دوره 49، شماره 4، تیر 2024، صفحه 219-228    اصل مقاله (514.98 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.98201.3012
نویسندگان
Azam Ahmadi-Vasmehjani1، 2؛ Seyed Mostafa SeyedHosseini3؛ Sayyed Saeid Khayyatzadeh1، 2؛ Farzan Madadizadeh4؛ Mahta Mazaheri-Naeini5، 6؛ Mahdie Yavari7، 8؛ Zahra Darabi1، 2؛ Sara Beigrezaei1، 2؛ Marzieh Taftian1، 2؛ Vahid Arabi1، 2؛ Maryam Motallaei1، 2؛ Amin Salehi-Abargouei1، 2؛ Azadeh Nadjarzadeh* 1، 2
1Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3Cardiovascular Research Center, Non-Communicable Diseases Research Institute, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
5Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, BP634, F8916978477 Yazd, Iran
6Mother and Newborn Health Research Center, Shahid Sadoughi Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
7Division of Genetics, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Biotechnology, University of Isfahan, Isfahan, Iran
8Dr. Mazaheri’s Medical Genetics Lab, Yazd, Iran
چکیده
Background: Several studies assessed the relationship between the cholesterol ester transfer protein (CETP) Taq1B gene polymorphism (rs708272) with risk factors of cardiovascular diseases (CVDs). However, their findings were inconsistent. The present study investigated the relationship between CVD risk factors and the Taq1B variant in patients undergoing coronary angiography. 
Methods: This cross-sectional study was conducted on 476 patients aged 30-76 years old of both sexes from 2020-2021, in Yazd (Iran). The Taq1B polymorphism genotypes were evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) on DNA extracted from whole blood. Standard protocols were used to measure cardio-metabolic markers. To determine the association between CVDs risk factors and the rs708272 variant, binary logistic regression was used in crude and adjusted models.
Results: Taq1B polymorphism genotype frequencies were 10.7% for B1B1, 72.3% for B1B2, and 17% for B2B2. There was no significant association between abnormal levels of CVDs risk factors and different genotypes of the Taq1B variant, Gensini score (P=0.64), Syntax score (P=0.79), systolic blood pressure (P=0.55), diastolic blood pressure (P=0.58), and waist circumference (P=0.79). There was no significant association between genotypes of the rs708272 variant and any abnormal serum lipid levels. After adjusting for confounders, the results remained non-significant.
Conclusion: There was no significant association between CVDs risk factors and CETP rs708272 polymorphism. The relationship between CETP gene variants and CVD occurrences varied across groups, implying that more research in different regions is required. 
A preprint version of this manuscript is available at https://www.researchsquare.com/article/rs-2575215/v1 with doi: 10.21203/rs.3.rs-2575215/v1.
کلیدواژه‌ها
Polymorphism, single nucleotide؛ Coronary angiography؛ Polymorphism, genetic
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