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Mao, Qifen, Zhang, Peng, Qi, Weicui, Xia, Yueping, Chen, Tingting, Li, Xiaofang, Xu, Songquan, Zhong, Zhiqiang, Shangguan, Zuifei. (1402). Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression. سامانه مدیریت نشریات علمی, 20(4), 427-437. doi: 10.22034/iji.2023.98917.2598
Qifen Mao; Peng Zhang; Weicui Qi; Yueping Xia; Tingting Chen; Xiaofang Li; Songquan Xu; Zhiqiang Zhong; Zuifei Shangguan. "Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression". سامانه مدیریت نشریات علمی, 20, 4, 1402, 427-437. doi: 10.22034/iji.2023.98917.2598
Mao, Qifen, Zhang, Peng, Qi, Weicui, Xia, Yueping, Chen, Tingting, Li, Xiaofang, Xu, Songquan, Zhong, Zhiqiang, Shangguan, Zuifei. (1402). 'Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression', سامانه مدیریت نشریات علمی, 20(4), pp. 427-437. doi: 10.22034/iji.2023.98917.2598
Mao, Qifen, Zhang, Peng, Qi, Weicui, Xia, Yueping, Chen, Tingting, Li, Xiaofang, Xu, Songquan, Zhong, Zhiqiang, Shangguan, Zuifei. Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression. سامانه مدیریت نشریات علمی, 1402; 20(4): 427-437. doi: 10.22034/iji.2023.98917.2598

Relationship between TIM3 Expression on Peripheral T Lymphocytes and Post-Stroke Depression

Iranian Journal of Immunology
مقاله 4، دوره 20، شماره 4، اسفند 2023، صفحه 427-437    اصل مقاله (1.92 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.98917.2598
نویسندگان
Qifen Mao1؛ Peng Zhang2؛ Weicui Qi3؛ Yueping Xia3؛ Tingting Chen4؛ Xiaofang Li4؛ Songquan Xu1؛ Zhiqiang Zhong4؛ Zuifei Shangguan* 4
1Department of Clinical Laboratory, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310012, China.
2Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, 311200, China.
3Lishui TCM Hospital Affiliated to Zhejiang Chinese Medical University (Lishui Hospital of Traditional Chinese Medicine), Lishui, Zhejiang, 323000, China.
4The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, 310006, China.
چکیده
Background: T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) is a regulatory molecule expressed on a variety of cell types, including CD3+ T cells. Few studies have been conducted to look into the correlation between TIM3 expression on peripheral T lymphocytes and post-stroke depression (PSD).
Objective: To investigate the relationship between TIM3 expressions on peripheral T lymphocytes in PSD patients.
Methods: Acute stroke patients without depression (NPSD) (n=65), PSD patients (n=23), and body mass index (BMI), age, and education-matched healthy controls (HC) (n=59) were enrolled. Using flow cytometry, TIM3 expression was examined in the peripheral CD3+ CD4+ and CD3+ CD8+ T lymphocytes. Evaluation of the depressive severity in PSD patients was assessed using a 17-item Hamilton Depression Rating Scale (HAM-D-17). We used enzyme-linked immunosorbent assay (ELISA) to determine the serum concentrations of IL-1β, IL-6, IL-10, and IL-18. We further assessed the relationships between TIM3 expression, serum cytokine levels, and the HAM-D-17 scores.
Results: CD3+ CD4+ T cells reduced significantly in PSD patients compared with the NPSD patients and HC. Both NPSD patients and PSD patients had a significant increase in TIM3 expression in their peripheral CD3+ CD4+ T lymphocytes, compared with HC. In PSD patients, a higher frequency of peripheral CD3+ CD8+ T lymphocytes showed significant expression of TIM3 compared to NPSD patients and HC. High TIM3 level on peripheral CD3+ CD8+ T lymphocytes was positively associated with the HAM-D score.
Conclusion: Patients with PSD exhibit immune dysfunction. TIM3 might contribute to the development and severity of PSD, making it a potential therapeutic target.
کلیدواژه‌ها
Interleukin؛ Mucin Domain-Containing Protein 3؛ Post-Stroke Depression؛ Therapeutic Target؛ T Lymphocyte
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