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Hegazy, Mohamed, Attallah, Hany, El-Shahat, Khaled, Mostafa, Emad, Yassin, Adel, Haggag, Ibraheem, Fathy, Talaat, Abdel Monem, Sameh, Abdelmoaty, Ahmed, Bessar, Ahmed. (1403). Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with or without Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort. سامانه مدیریت نشریات علمی, 15(3), 242-248. doi: 10.30476/mejc.2023.98866.1918
Mohamed Wahba Hegazy; Hany Attallah; Khaled M. El-Shahat; Emad Mostafa; Adel Yassin; Ibraheem Haggag; Talaat Fathy; Sameh M. Abdel Monem; Ahmed Abdelmoaty; Ahmed A. Bessar. "Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with or without Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort". سامانه مدیریت نشریات علمی, 15, 3, 1403, 242-248. doi: 10.30476/mejc.2023.98866.1918
Hegazy, Mohamed, Attallah, Hany, El-Shahat, Khaled, Mostafa, Emad, Yassin, Adel, Haggag, Ibraheem, Fathy, Talaat, Abdel Monem, Sameh, Abdelmoaty, Ahmed, Bessar, Ahmed. (1403). 'Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with or without Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort', سامانه مدیریت نشریات علمی, 15(3), pp. 242-248. doi: 10.30476/mejc.2023.98866.1918
Hegazy, Mohamed, Attallah, Hany, El-Shahat, Khaled, Mostafa, Emad, Yassin, Adel, Haggag, Ibraheem, Fathy, Talaat, Abdel Monem, Sameh, Abdelmoaty, Ahmed, Bessar, Ahmed. Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with or without Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort. سامانه مدیریت نشریات علمی, 1403; 15(3): 242-248. doi: 10.30476/mejc.2023.98866.1918

Stereotactic Body Radiotherapy in Bulky Hepatocellular Carcinoma with or without Portal Vein Thrombosis: A Feasibility Review in an Egyptian Cohort

Middle East Journal of Cancer
مقاله 25، دوره 15، شماره 3 - شماره پیاپی 59، مهر 2024، صفحه 242-248    اصل مقاله (398.7 K)
نوع مقاله: Brief Report(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.98866.1918
نویسندگان
Mohamed Wahba Hegazy* 1؛ Hany Attallah2؛ Khaled M. El-Shahat3؛ Emad Mostafa4؛ Adel Yassin3؛ Ibraheem Haggag4؛ Talaat Fathy5؛ Sameh M. Abdel Monem5؛ Ahmed Abdelmoaty5؛ Ahmed A. Bessar6
1Department of Clinical Oncology and Nuclear Medicine, Medicine College, Zagazig, Egypt
2Department of Radiation Oncology, International Medical Center (IMC), Cairo, Egypt
3Department of Clinical Oncology, Al-Azhar College of Medicine, Cairo, Egypt
4Medical Radiation Physics, International Medical Center, Cairo, Egypt
5Tropica Department, College of Medicine, Zagazig, Egypt
6Radiology Department, College of Medicine, Zagazig, Egypt
چکیده
Background: Hepatocellular carcinoma (HCC) complicated by portal vein thrombosis presents significant clinical challenges. This study aims to retrospectively assess the feasibility of stereotactic irradiation for treating bulky HCC, with or without vascular invasion.
Method: In this retrospective analysis, the radiotherapy treatment plans and clinical follow-up data of 22 patients diagnosed with HCC, with or without portal vein thrombosis, were reviewed. These patients underwent stereotactic body radiation therapy (SBRT) between September 2019 and September 2022. Treatment involved administering 40-50 Gy in 5 fractions using SBRT with volumetric modulated arc therapy (VMAT)/4D-computed tomography. Descriptive statistics were utilized without the application of statistical tests.
Results: The mean age of the patients was 65 years, with 77% being male. Portal vein thrombosis was present in 73% of the cases, and the average tumor size was 7.2 cm (range 5-12 cm). 59% of patients were classified as Child-Pugh B. The median follow-up duration was 8 months (range 3-36 months). At 3 months, tumor response assessments revealed that 59% of patients had a partial response and 41% had stable disease; by 6 months, 37% achieved complete response, 26% maintained a partial response, and 37% had stable condition. Failure patterns included intrahepatic failure in two patients (at 7 and 9 months) and extrahepatic loss in two others (at 6 and 10 months). Radiation-induced liver disease occurred in two patients at 9- and 11-weeks post-treatment, respectively. Liver cancer-specific mortality was 13.6%, while non-liver cancer-specific mortality stood at 9%. The progression-free survival rate was 82%.
Conclusion: SBRT via VMAT represents a highly cost-effective, non-invasive local therapy with a favorable therapeutic ratio for treating bulky HCC cases, with or without vascular invasion.

تازه های تحقیق

Mohamed Wahba Hegazy (Scopus)

کلیدواژه‌ها
Stereotactic؛ Hepatocellular؛ Portal؛ Veins؛ Thrombosis
مراجع
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