Zoledronic acid-induced mitochondrial impairment, inflammation, and oxidative stress in the rat kidney | ||
| Trends in Pharmaceutical Sciences and Technologies | ||
| مقاله 2، دوره 9، شماره 4، زمستان 2023، صفحه 243-252 اصل مقاله (802.1 K) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.30476/tips.2023.100490.1218 | ||
| نویسندگان | ||
| Heresh Rezaei1؛ Ayeh Rowhanirad1؛ Jale Yüzügülen2؛ Fatemeh Ghaderi1؛ Rahil Fazlinezhad1؛ Mohammad Reza Kiafar1؛ Zahra Honarpishefard1؛ Pargol Matinpour2؛ Abdollah Arjmand3؛ Negar Azarpira4؛ Seyed Mohammad Amin Kashani1؛ Forouzan Khodaei1؛ Akram Jamshidzadeh1؛ Reza Heidari* 1 | ||
| 1Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 2Eastern Mediterranean University, Faculty of Pharmacy, Famagusta, North Cyprus, Turkey | ||
| 3Department of Pharmacology and Toxicology, Shahid Beheshti University of Medical Sciences, Faculty of Pharmacy, Tehran, Iran | ||
| 4Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| Zoledronic acid (ZLD) is a bisphosphonate drug widely administered against pathological conditions such as hypercalcemia of malignancy, osteoporosis, bone metastases from solid tumors, and multiple myeloma. Unfortunately, renal injury is a serious and dose-limiting adverse effect of ZLD. There is no specific mechanism for ZLD-induced renal damage. The current study aimed to assess the effects of ZLD (10 and 15 mg/kg, i.p., single dose) on the rat kidney. In this regard, several parameters, including oxidative stress biomarkers, serum level of BUN and creatinine, inflammatory cytokines, kidney histopathology, and indices of mitochondrial function were assessed. A significant increase in serum Cr and BUN revealed renal injury. Moreover, kidney histopathological changes, including interstitial inflammation, tissue necrosis, and tubular atrophy, were detected in ZLD-treated rats. Biomarkers of oxidative stress, including a significant increase in reactive oxygen species (ROS), depletion of kidney glutathione (GSH) stores, increased lipid peroxidation, and suppression of the total antioxidant capacity, were detected in ZLD-treated animals. ZLD also significantly increased renal levels of TNF-α, IL-6, and IL-1β. ZLD exposure was also associated with significantly decreased mitochondrial dehydrogenases activity, mitochondrial depolarization, mitochondrial permeabilization, and ATP depletion. These data highlight mitochondrial dysfunction, inflammatory response, and oxidative stress as potential mechanisms in ZLD-induced kidney injury. | ||
تازه های تحقیق | ||
Heresh Rezaei (Google Scholar) Reza Heidari (Google Scholar) | ||
| کلیدواژهها | ||
| Bisphosphonates؛ Drug safety؛ Mitochondrial dysfunction؛ Kidney Injury؛ Renal Failure؛ Pharmacotherapy | ||
| مراجع | ||
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