LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,142
تعداد مقالات10,469
تعداد مشاهده مقاله44,879,536
تعداد دریافت فایل اصل مقاله10,798,252
Sharifian, Azadeh, Aghili, Mahdi. (1403). The Role of Lovastatin in Curative Chemoradiotherapy for Patients with Head and Neck Cancer: A Randomized Trial. سامانه مدیریت نشریات علمی, 15(2), 117-127. doi: 10.30476/mejc.2023.97387.1911
Azadeh Sharifian; Mahdi Aghili. "The Role of Lovastatin in Curative Chemoradiotherapy for Patients with Head and Neck Cancer: A Randomized Trial". سامانه مدیریت نشریات علمی, 15, 2, 1403, 117-127. doi: 10.30476/mejc.2023.97387.1911
Sharifian, Azadeh, Aghili, Mahdi. (1403). 'The Role of Lovastatin in Curative Chemoradiotherapy for Patients with Head and Neck Cancer: A Randomized Trial', سامانه مدیریت نشریات علمی, 15(2), pp. 117-127. doi: 10.30476/mejc.2023.97387.1911
Sharifian, Azadeh, Aghili, Mahdi. The Role of Lovastatin in Curative Chemoradiotherapy for Patients with Head and Neck Cancer: A Randomized Trial. سامانه مدیریت نشریات علمی, 1403; 15(2): 117-127. doi: 10.30476/mejc.2023.97387.1911

The Role of Lovastatin in Curative Chemoradiotherapy for Patients with Head and Neck Cancer: A Randomized Trial

Middle East Journal of Cancer
مقاله 5، دوره 15، شماره 2 - شماره پیاپی 58، تیر 2024، صفحه 117-127    اصل مقاله (1.09 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.97387.1911
نویسندگان
Azadeh Sharifian* 1؛ Mahdi Aghili2
1Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
2Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Background: Evidence suggests that statins can improve survival outcomes and ameliorate treatment-related side-effects in certain malignancies. Statins exhibit various mechanisms of action, including apoptosis induction, proliferation inhibition, tumor radiosensitization, lipid production suppression, and anti-inflammatory effects. This trial aimed to assess the impact of lovastatin on patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing definitive chemoradiation.
Method: In this double-blinded randomized phase 2 clinical trial, 35 patients were randomly allocated to receive either 80 mg of lovastatin daily in conjunction with chemoradiotherapy (case group, n=18) or a placebo (control group). Primary outcomes included the response rate (RR) after three months, the occurrence of acute/late side-effects, median progression-free survival (PFS), and overall survival (OS).
Results: The complete RR was slightly higher in the statin group (83.3% vs. 64.7%), although it did not reach statistical significance (P = 0.592). Acute adverse events did not significantly differ between the two groups. Grade 3 dermatitis occurred more frequently in the placebo group (35.3% vs. 11.1%), while grade 3 mucositis was more common in the statin group (38.9% vs. 11.8%). The median OS was 22 months (confidence interval (CI) 95% = 6.3-37.6) in the statin group and 17 months (CI 95% = 4.9-29.1) in the control group (P = 0.50). Median PFS was 20 months (CI 95% = 15.8-24.1) in the statin group and 15 months (CI 95% = 8.2-21.7) in the control group (P = 0.609).
Conclusion: Combining lovastatin with chemoradiation augments the therapeutic effect in HNSCC. Larger-scale studies incorporating advanced radiotherapy techniques and baseline lipid profile assessments are necessary to investigate statins' efficacy in HNSCC further.
کلیدواژه‌ها
Head and neck neoplasms؛ Squamous cell carcinoma؛ Statin؛ Chemoradiotherapy
اصل مقاله

This article has been corrected. See Middle East J Cancer. 2024 July; 15(3)
. doi: 10.30476/mejc.2024.102844.2112

مراجع
  1. Halperin EC, Brady LW, Wazer DE, Perez CA. Perez and Brady's: Principles and practice of radiation oncology. In: Edward C. Halperin, David E. Wazer, Carlos A. Perez, Luther W, editors. Locally advance squamous carcinoma of the head and neck. 7th Philadelphia: Lippincott Williams & Wilkins; 2013.p.885.
  2. DeVita VT, Lawrence TS, Rosenberg SA. DeVita, Hellman, and Rosenberg's cancer: Principles and practice of oncology. In: Vincent T. DeVita Jr., Theodore S. Lawrence, Steven A, editors. Cancer of head and neck. 11th The United Stated: EBSCO eBooks; 2019.p. 542.
  3. Knox JJ, Siu LL, Chen E, Dimitroulakos J, Kamel-Reid S, Moore MJ, et al. A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix. Eur J Cancer. 2005;41(4):523-30. doi: 10.1016/j.ejca.2004.12.013.
  4. Apostolova SN, Toshkova RA, Momchilova AB, Tzoneva RD. Statins and Alkylphospholipids as new anticancer agents targeting lipid metabolism. Anticancer Agents Med Chem. 2016;16(12):1512-22. doi: 10.2174/1871520616666160624093955.
  5. Altwairgi AK. Statins are potential anticancerous agents (review). Oncol Rep. 2015;33(3):1019-39. doi: 10.3892/or.2015.3741.
  6. Di Bello E, Zwergel C, Mai A, Valente S. The innovative potential of statins in cancer: new targets for new therapies. Front Chem. 2020;8:516. doi: 10.3389/fchem.2020.00516.
  7. Gazzerro P, Proto MC, Gangemi G, Malfitano AM, Ciaglia E, Pisanti S, et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol Rev. 2012;64(1):102-46. doi: 10.1124/pr.111.004994.
  8. Dimitroulakos J, Marhin WH, Tokunaga J, Irish J, Gullane P, Penn LZ, et al. Microarray and biochemical analysis of lovastatin-induced apoptosis of squamous cell carcinomas. 2002;4(4):337-46. doi: 10.1038/sj.neo.7900247.
  9. Gupta A, Stokes W, Eguchi M, Hararah M, Amini A, Mueller A, et al. Statin use associated with improved overall and cancer specific survival in patients with head and neck cancer. Oral Oncol. 2019;90:54-66. doi: 10.1016/j.oraloncology.2019.01.019.
  10. Lebo NL, Griffiths R, Hall S, Dimitroulakos J, Johnson-Obaseki S. Effect of statin use on oncologic outcomes in head and neck squamous cell carcinoma. Head Neck. 2018;40(8):1697-706. doi: 10.1002/hed.25152.
  11. Hindler K, Cleeland CS, Rivera E, Collard CD. The role of statins in cancer therapy. 2006;11(3):306-15. doi: 10.1634/theoncologist.11-3-306.
  12. Davies JT, Delfino SF, Feinberg CE, Johnson MF, Nappi VL, Olinger JT, et al. Current and emerging uses of statins in clinical therapeutics: a review. Lipid Insights. 2016;9:13-29. doi: 10.4137/LPI.S37450.
  13. Jeong GH, Lee KH, Kim JY, Eisenhut M, Kronbichler A, van der Vliet HJ, et al. Statin and cancer mortality and survival: an umbrella systematic review and meta-analysis. J Clin Med. 2020;9(2):326. doi: 10.3390/jcm9020326.
  14. Katz MS, Minsky BD, Saltz LB, Riedel E, Chessin DB, Guillem JG. Association of statin use with a pathologic complete response to neoadjuvant chemoradiation for rectal cancer. Int J Radiat Oncol Biol Phys. 2005;62(5):1363-70. doi: 10.1016/j.ijrobp.2004.12.033.
  15. Shen Y, Wang C, Ren Y, Ye J. A comprehensive look at the role of hyperlipidemia in promoting colorectal cancer liver metastasis. J Cancer. 2018;9(16):2981-6. doi: 10.7150/jca.25640
  16. Tan P, Wei S, Yang L, Tang Z, Cao D, Liu L, et al. The effect of statins on prostate cancer recurrence and mortality after definitive therapy: a systematic review and meta-analysis. Sci Rep. 2016;6:29106. doi: 10.1038/srep29106.
  17. Ling Y, Yang L, Huang H, Hu X, Zhao C, Huang H, et al. Prognostic significance of statin use in colorectal cancer: a systematic review and meta-analysis. Medicine (Baltimore). 2015;94(25):e908. doi: 10.1097/MD.0000000000000908.
  18. Chen Y, Li X, Zhang R, Xia Y, Shao Z, Mei Z. Effects of statin exposure and lung cancer survival: A meta-analysis of observational studies. Pharmacol Res. 2019;141:357-65. doi: 10.1016/j.phrs.2019.01.016.
  19. Raval AD, Thakker D, Negi H, Vyas A, Kaur H, Salkini MW. Association between statins and clinical outcomes among men with prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2016;19(2):151-62. doi: 10.1038/pcan.2015.58. Erratum in: Prostate Cancer Prostatic Dis. 2016;19(2):222.
  20. Danzig MR, Kotamarti S, Ghandour RA, Rothberg MB, Dubow BP, Benson MC, et al. Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes. Prostate Cancer Prostatic Dis. 2015;18(1):63-8. doi: 10.1038/pcan.2014.47.
  21. Li Y, Li Y, Lei X, Liu L, Zhang D, Tang S. Prognostic value of statin for cancer patients: 
A meta-analysis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2015;40(7):770-81. doi: 10.11817/j.issn.1672-7347.2015.07.012.
  22. Allott EH, Howard LE, Cooperberg MR, Kane CJ, Aronson WJ, Terris MK, et al. Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. BJU Int. 2014;114(5):661-6. doi: 10.1111/bju.12720.
  23. Cai H, Zhang G, Wang Z, Luo Z, Zhou X. Relationship between the use of statins and patient survival in colorectal cancer: a systematic review and meta-analysis. PLoS One. 2015;10(6):e0126944. doi: 10.1371/journal.pone.0126944.
  24. Razmjoo S, Hoseyni M, Shahbazian H, Arvandi S, Ghadamgahi P. A phase III randomized clinical trial study of chemoradiation using lovastatin/cisplatin in patients with head and neck squamous cell carcinoma. Middle East J Cancer. 2022;13(1):120-7. doi: 10.30476/mejc.2021.87318.1407.
آمار
تعداد مشاهده مقاله: 738
تعداد دریافت فایل اصل مقاله: 229


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب