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Fatahi Asl, Jafar, Goudarzi, Mehdi, Mansouri, Esrafil, Shoghi, Hamed. (1403). Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity. سامانه مدیریت نشریات علمی, 49(4), 237-246. doi: 10.30476/ijms.2023.97695.2952
Jafar Fatahi Asl; Mehdi Goudarzi; Esrafil Mansouri; Hamed Shoghi. "Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity". سامانه مدیریت نشریات علمی, 49, 4, 1403, 237-246. doi: 10.30476/ijms.2023.97695.2952
Fatahi Asl, Jafar, Goudarzi, Mehdi, Mansouri, Esrafil, Shoghi, Hamed. (1403). 'Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity', سامانه مدیریت نشریات علمی, 49(4), pp. 237-246. doi: 10.30476/ijms.2023.97695.2952
Fatahi Asl, Jafar, Goudarzi, Mehdi, Mansouri, Esrafil, Shoghi, Hamed. Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity. سامانه مدیریت نشریات علمی, 1403; 49(4): 237-246. doi: 10.30476/ijms.2023.97695.2952

Rosmarinic Acid Protects the Testes of Rats against Cell Phone and Ultra-high Frequency Waves Induced Toxicity

Iranian Journal of Medical Sciences
مقاله 4، دوره 49، شماره 4، تیر 2024، صفحه 237-246    اصل مقاله (3.02 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.97695.2952
نویسندگان
Jafar Fatahi Asl1؛ Mehdi Goudarzi2؛ Esrafil Mansouri3؛ Hamed Shoghi* 4
1Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4Department of Physiology, Pharmacology and Medical Physics, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran
چکیده
Background: Cell phone and Ultra-High Frequency (UHF) waves produce oxidative stress and cause testicular toxicity. This investigation was directed to evaluate the effectiveness of Rosmarinic Acid (RA) against oxidative stress caused by UHF radiation in rats.
Methods: Forty-two male Wistar rats were divided into six groups. The control received 5 mL normal saline (0.9% NaCl) by gavage, the cell phone group received 915 MHz, the UHF waves group just received 2450 MHz, the RA/cell phone group received RA plus 915 MHz, RA/UHF waves group received RA plus 2450 MHz, and RA just received RA (20 mg/kg). After 30 days of consecutive radiation, the biochemical and histopathological parameters of their testes were measured. Statistical comparison was made using one-way ANOVA followed by Tukey’s post hoc test.
Results: Cell phone and UHF wave radiation significantly diminished the activity of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase, and glutathione content (P<0.001). On the opposite, UHF significantly increased oxidative stress indices including malondialdehyde level, nitric oxide level, and protein carbonyl content (P<0.001). UHF also significantly reduced the number of Sertoli cells, spermatogonia, primary spermatocyte, epithelial height, and seminiferous tubular and luminal diameters (P<0.001). RA, as an effective antioxidant, reverses the above-mentioned harms and moderates the adverse effects of UHF on the testes of rats by significantly diminishing the oxidative stress indices and antioxidant enzyme rise and improving the histological parameters (P<0.001).
Conclusion: RA can protect the testes of rats from UHF-induced toxicity by reducing oxidative stress. RA as a food supplement might be useful for protecting humans exposed to UHF environmental contamination.
کلیدواژه‌ها
Rosmarinic acid؛ Testes, Oxidative stress؛ UHF waves, cell phone
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