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Radmanesh, Fatemeh, Monabati, Ahmad, Motavas, Maedeh, Rezvani, Alireza, Montazer, Mehdi. (1403). Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran. سامانه مدیریت نشریات علمی, 15(2), 89-97. doi: 10.30476/mejc.2023.98321.1891
Fatemeh Radmanesh; Ahmad Monabati; Maedeh Motavas; Alireza Rezvani; Mehdi Montazer. "Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran". سامانه مدیریت نشریات علمی, 15, 2, 1403, 89-97. doi: 10.30476/mejc.2023.98321.1891
Radmanesh, Fatemeh, Monabati, Ahmad, Motavas, Maedeh, Rezvani, Alireza, Montazer, Mehdi. (1403). 'Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran', سامانه مدیریت نشریات علمی, 15(2), pp. 89-97. doi: 10.30476/mejc.2023.98321.1891
Radmanesh, Fatemeh, Monabati, Ahmad, Motavas, Maedeh, Rezvani, Alireza, Montazer, Mehdi. Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran. سامانه مدیریت نشریات علمی, 1403; 15(2): 89-97. doi: 10.30476/mejc.2023.98321.1891

Prevalence and Prognostic Impact of MYC, BCL2, and BCL6 Rearrangements in Large B Cell Lymphoma Patients: A Multicenter Historical Cohort Study from Iran

Middle East Journal of Cancer
مقاله 2، دوره 15، شماره 2 - شماره پیاپی 58، تیر 2024، صفحه 89-97    اصل مقاله (2.42 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.98321.1891
نویسندگان
Fatemeh Radmanesh1؛ Ahmad Monabati2؛ Maedeh Motavas1؛ Alireza Rezvani3؛ Mehdi Montazer* 2
1Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, Iran
3Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background: Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin's lymphoma, characterized by remarkable molecular heterogeneity. This study evaluates the prevalence of MYC, BCL2, and BCL6 gene rearrangements among Iranian DLBCL patients.
Method: This historical cohort study encompassed 152 patients drawn from six reference hospitals who participated in the research. Interphase dual-color break-apart fluorescence in situ hybridization (FISH) was applied to formalin-fixed paraffin-embedded DLBCL specimens categorized as "not otherwise specified" alongside 20 normal controls. Survival data was analyzed using the Kaplan-Meier method and the Log-Rank test.
Results: Among the patients, 7 (4.8%), 4 (2.9%), and 15 (10.2%) exhibited MYC, BCL2, and BCL6 rearrangements, respectively. Additionally, 1.5% of the patients demonstrated double-hit (DH) characteristics with both MYC and BCL2 rearrangements, while no triple rearrangements were observed. The presence of rearrangements appeared to be independent of clinicopathological variables. Patients with rearrangements experienced reduced survival durations, with reductions of 26.6, 31.2, 9.1, and 34.2 months for MYC, BCL2, BCL6-rearranged, and DH tumors, respectively (P > 0.05). Adverse prognosis was associated with age, activated B-cell-like phenotype, disease stage, B symptoms, lactate dehydrogenase levels, and risk grouping according to the National Comprehensive Cancer Network (NCCN) International Prognostic Index.
Conclusion: DLBCL cases featuring MYC, BCL2, and/or BCL6 translocations are relatively rare. Patients harboring these rearrangements tend to exhibit aggressive disease progression with shortened overall survival. However, these differences did not reach statistical significance, necessitating further research to validate the incorporation of such tests into the routine workup of DLBCL patients.

تازه های تحقیق

Mehdi Montazer (Google Scholar)

کلیدواژه‌ها
Diffuse large B cell lymphoma؛ Gene rearrangement؛ MYC؛ BCL2؛ BCL6
مراجع
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