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Motahari, Paria, Pakdel, Farzaneh, Hashemzadeh, Nastaran, Heydari, Farid, Eghdam Zamiri, Reza, Katebi, Katayoun. (1403). The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 15(2), 108-116. doi: 10.30476/mejc.2023.98297.1889
Paria Motahari; Farzaneh Pakdel; Nastaran Hashemzadeh; Farid Heydari; Reza Eghdam Zamiri; Katayoun Katebi. "The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 15, 2, 1403, 108-116. doi: 10.30476/mejc.2023.98297.1889
Motahari, Paria, Pakdel, Farzaneh, Hashemzadeh, Nastaran, Heydari, Farid, Eghdam Zamiri, Reza, Katebi, Katayoun. (1403). 'The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 15(2), pp. 108-116. doi: 10.30476/mejc.2023.98297.1889
Motahari, Paria, Pakdel, Farzaneh, Hashemzadeh, Nastaran, Heydari, Farid, Eghdam Zamiri, Reza, Katebi, Katayoun. The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1403; 15(2): 108-116. doi: 10.30476/mejc.2023.98297.1889

The Effect of 1% Pilocarpine Mouthwash on Salivary Flow Rate in Patients with Radiation-Induced Xerostomia: A Double-Blind Randomized Clinical Trial

Middle East Journal of Cancer
مقاله 4، دوره 15، شماره 2 - شماره پیاپی 58، تیر 2024، صفحه 108-116    اصل مقاله (1.24 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.98297.1889
نویسندگان
Paria Motahari1؛ Farzaneh Pakdel1؛ Nastaran Hashemzadeh2؛ Farid Heydari1؛ Reza Eghdam Zamiri3؛ Katayoun Katebi* 1
1Department of Oral and Maxillofacial Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3Department of Radiation Oncology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background: Radiation-induced hyposalivation is a common complication of radiotherapy for head and neck cancers. The most commonly prescribed medication for hyposalivation is pilocarpine. However, due to the numerous systemic side-effects associated with pilocarpine, there has been a proposal to use it as a mouthwash. This study aimed to evaluate the impact of 1% pilocarpine mouthwash on salivary flow in patients with radiation-induced xerostomia.
Method: This double-blind, randomized clinical trial involved 63 patients with radiation-induced xerostomia. The patients were randomly allocated into the pilocarpine hydrochloride 1% mouthwash group and the placebo one. Patients were instructed to use these mouthwashes four times a day, with 30 drops each time, for two minutes. Unstimulated saliva production in patients was measured using the spitting method at three stages: two weeks before the commencement of radiotherapy, two weeks after, and four weeks after the completion of radiotherapy. These measurements were then compared between the two groups. Statistical analysis included chi-square, independent t-test, and Analysis of Variance (ANOVA) with repeated measures and the Sidak post hoc test. Statistical analysis was conducted using SPSS 17, and a significance level of P < 0.05 was applied.
Results: A comparison of saliva secretion between the pilocarpine mouthwash group and the control group at various time points after radiotherapy revealed that saliva secretion in the control group significantly decreased compared with the pilocarpine mouthwash group (P < 0.001).
Conclusion: 1% pilocarpine mouthwash is recommended for managing radiationinduced xerostomia.

تازه های تحقیق

Paria Motahari (Google Scholar)

Katayoun Katebi (Google Scholar)

کلیدواژه‌ها
Head and neck neoplasms؛ Salivation؛ Mouthwashes؛ Pilocarpine؛ Radiotherapy
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