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Akhlaq, Kalsoom, Khan, Hadi, Ali, Zafar, Atiq, Muslim, Riyaz, Shahzad, Raja, Umar, Kiani, Amen. (1403). Pancreatic Neuroendocrine Tumors: Spectrum of Clinical Presentation from a Tertiary Referral Center in Pakistan. سامانه مدیریت نشریات علمی, 15(2), 145-152. doi: 10.30476/mejc.2023.98055.1883
Kalsoom Akhlaq; Hadi Khan; Zafar Ali; Muslim Atiq; Shahzad Riyaz; Umar Yousaf Raja; Amen Kiani. "Pancreatic Neuroendocrine Tumors: Spectrum of Clinical Presentation from a Tertiary Referral Center in Pakistan". سامانه مدیریت نشریات علمی, 15, 2, 1403, 145-152. doi: 10.30476/mejc.2023.98055.1883
Akhlaq, Kalsoom, Khan, Hadi, Ali, Zafar, Atiq, Muslim, Riyaz, Shahzad, Raja, Umar, Kiani, Amen. (1403). 'Pancreatic Neuroendocrine Tumors: Spectrum of Clinical Presentation from a Tertiary Referral Center in Pakistan', سامانه مدیریت نشریات علمی, 15(2), pp. 145-152. doi: 10.30476/mejc.2023.98055.1883
Akhlaq, Kalsoom, Khan, Hadi, Ali, Zafar, Atiq, Muslim, Riyaz, Shahzad, Raja, Umar, Kiani, Amen. Pancreatic Neuroendocrine Tumors: Spectrum of Clinical Presentation from a Tertiary Referral Center in Pakistan. سامانه مدیریت نشریات علمی, 1403; 15(2): 145-152. doi: 10.30476/mejc.2023.98055.1883

Pancreatic Neuroendocrine Tumors: Spectrum of Clinical Presentation from a Tertiary Referral Center in Pakistan

Middle East Journal of Cancer
مقاله 17، دوره 15، شماره 2 - شماره پیاپی 58، تیر 2024، صفحه 145-152    اصل مقاله (4.3 M)
نوع مقاله: Brief Report(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.98055.1883
نویسندگان
Kalsoom Akhlaq1؛ Hadi Khan2؛ Zafar Ali3؛ Muslim Atiq* 1؛ Shahzad Riyaz1؛ Umar Yousaf Raja4؛ Amen Kiani2
1Department of Gastroenterology, Shifa International Hospital, Islamabad, Pakistan
2Department of Surgery, Shifa International Hospital, Islamabad, Pakistan
3Department of Pathology, Shifa International Hospital, Islamabad, Pakistan
4Department of Endocrinology, Shifa International Hospital, Islamabad, Pakistan
چکیده
Background: Pancreatic neuroendocrine tumors (P-NETs) constitute a subset of pancreatic mass lesions characterized by diverse clinical presentations. Despite their inherent malignant potential, the timely identification and treatment of these tumors are critical for achieving favorable clinical outcomes. This study aims to shed light on the heterogeneous tumor biology of P-NETs and the management strategies employed at a tertiary care center in Pakistan.
Method: A retrospective study encompassing all patients with a biopsy-confirmed diagnosis of P-NETs at Shifa International Hospital between January 1st, 2016, and June 30th, 2021, was conducted. Meticulous data extraction from pathology records and thorough searches of medical records were performed to gather relevant demographic and clinical information.
Results: A total of 24 patients were retrieved from our database, with 13 (54%) female patients. The mean age was 49.5 ± 16.3 years. Eight out of the 24 patients presented with abdominal pain. Most patients (14 out of 24) had lesions in the pancreatic head region. In three cases, lesions exhibited multicentricity. The mean lesion size measured 4.4 ± 2.3 cm. Three of the 24 patients displayed distant liver metastasis at the presentation time. 19 out of the 24 patients underwent surgical resections, while endoscopic ultrasound (EUS)-guided biopsy was performed in 4 out of 24 cases. EUS-guided tissue biopsy yielded accurate diagnoses in all four cases.
Conclusion: Most P-NETs are non-functional, and there is an almost equal distribution between male and female patients. Solitary lesions predominate, and metastasis is uncommon at initial presentation. EUS-guided fine needle biopsy stands out as a dependable diagnostic modality for P-NETs.

تازه های تحقیق

Muslim Atiq (PubMed)

کلیدواژه‌ها
Neuroendocrine tumors؛ Pancreas؛ Clinical presentation؛ Management؛ Diagnosis
مراجع
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