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Kencana, Sagita Mega Sekar, Arfian, Nur, Yuniartha, Ratih, Saputri, Ramadhea Laila Afifa An-Nur Willya, Munawaroh, Fauziyatul, Sari, Dwi Cahyani Ratna. (1402). Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2023.96535.2868
Sagita Mega Sekar Kencana; Nur Arfian; Ratih Yuniartha; Ramadhea Laila Afifa An-Nur Willya Saputri; Fauziyatul Munawaroh; Dwi Cahyani Ratna Sari. "Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.30476/ijms.2023.96535.2868
Kencana, Sagita Mega Sekar, Arfian, Nur, Yuniartha, Ratih, Saputri, Ramadhea Laila Afifa An-Nur Willya, Munawaroh, Fauziyatul, Sari, Dwi Cahyani Ratna. (1402). 'Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2023.96535.2868
Kencana, Sagita Mega Sekar, Arfian, Nur, Yuniartha, Ratih, Saputri, Ramadhea Laila Afifa An-Nur Willya, Munawaroh, Fauziyatul, Sari, Dwi Cahyani Ratna. Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.30476/ijms.2023.96535.2868

Chlorogenic Acid Inhibits Progressive Pulmonary Fibrosis in a Diabetic Rat Model

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 06 آبان 1402    اصل مقاله (2.68 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.96535.2868
نویسندگان
Sagita Mega Sekar Kencana1، 2؛ Nur Arfian* 3؛ Ratih Yuniartha1؛ Ramadhea Laila Afifa An-Nur Willya Saputri1، 2؛ Fauziyatul Munawaroh2، 4؛ Dwi Cahyani Ratna Sari1
1Department of Anatomy, School of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
2Master Program in Biomedical Sciences, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
3Department of Anatomy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
4Faculty of Medicine, IPB University, Bogor, West Java, Indonesia
چکیده
Background: Chlorogenic acid (CGA) is known to have antifibrotic and hypoglycemic effects and may play a role in preventing diabetes-induced pulmonary fibrosis. This study aimed to determine the effect and optimum dose of CGA on diabetes-induced pulmonary fibrosis.
Methods: Thirty Wistar rats (two-month-old, 150-200 grams) were randomly divided into six groups, namely control, six weeks diabetes mellitus (DM1), eight weeks DM (DM2), and three DM2 groups (CGA1, CGA2, and CGA3) who received CGA doses of 12.5, 25, and 50 mg/Kg BW, respectively. After six weeks, CGA was administered intraperitoneally for 14 consecutive days. Lung tissues were taken for TGF-β1, CTGF, SMAD7, Collagen-1, and α-SMA mRNA expression analysis and paraffin embedding. Data were analyzed using one-way ANOVA and the Kruskal-Wallis test. P<0.05 was considered statistically significant.
Results: TGF-β1 expression in the CGA1 group (1.01±0.10) was lower than the DM1 (1.33±0.25, P=0.05) and DM2 (1.33±0.20, P=0.021) groups. α-SMA expression in the CGA1 group (median 0.60, IQR: 0.34-0.64) was lower than the DM1 (median 0.44, IQR: 0.42-0.80) and DM2 (median 0.76, IQR: 0.66-1.10) groups. Collagen-1 expression in the CGA1 group (0.75±0.13) was lower than the DM1 (P=0.24) and DM2 (P=0.26) groups, but not statistically significant. CTGF expression in CGA groups was lower than the DM groups (P=0.088), but not statistically significant. There was an increase in SMAD7 expression in CGA groups (P=0.286). Histological analysis showed fibrosis improvement in the CGA1 group compared to the DM groups.
Conclusion: CGA (12.5 mg/Kg BW) inhibited the expression of profibrotic factors and increased antifibrotic factors in DM-induced rats.
کلیدواژه‌ها
Pulmonary fibrosis؛ Diabetes mellitus؛ Chlorogenic acid
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