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Alabiad, Mohamed Ali, Said, Warda M. M., Saad, Rema H Faraj, Balata, Rawda, Mahmoud, Asmaa A., Metwally, Elsayed Anany, Shalaby, Amany Mohamed, Samy, Walaa, Yehia, Ahmed M., Yahia, Amar Ibrahim Omar, Alorini, Mohammed, Abdelrahman, Doaa I.. (1402). Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways. سامانه مدیریت نشریات علمی, 49(2), 88-100. doi: 10.30476/ijms.2023.97287.2896
Mohamed Ali Alabiad; Warda M. M. Said; Rema H Faraj Saad; Rawda Balata; Asmaa A. Mahmoud; Elsayed Anany Metwally; Amany Mohamed Shalaby; Walaa Samy; Ahmed M. Yehia; Amar Ibrahim Omar Yahia; Mohammed Alorini; Doaa I. Abdelrahman. "Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways". سامانه مدیریت نشریات علمی, 49, 2, 1402, 88-100. doi: 10.30476/ijms.2023.97287.2896
Alabiad, Mohamed Ali, Said, Warda M. M., Saad, Rema H Faraj, Balata, Rawda, Mahmoud, Asmaa A., Metwally, Elsayed Anany, Shalaby, Amany Mohamed, Samy, Walaa, Yehia, Ahmed M., Yahia, Amar Ibrahim Omar, Alorini, Mohammed, Abdelrahman, Doaa I.. (1402). 'Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways', سامانه مدیریت نشریات علمی, 49(2), pp. 88-100. doi: 10.30476/ijms.2023.97287.2896
Alabiad, Mohamed Ali, Said, Warda M. M., Saad, Rema H Faraj, Balata, Rawda, Mahmoud, Asmaa A., Metwally, Elsayed Anany, Shalaby, Amany Mohamed, Samy, Walaa, Yehia, Ahmed M., Yahia, Amar Ibrahim Omar, Alorini, Mohammed, Abdelrahman, Doaa I.. Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways. سامانه مدیریت نشریات علمی, 1402; 49(2): 88-100. doi: 10.30476/ijms.2023.97287.2896

Epstein-Barr Virus Promotes Tumorigenicity and Worsens Hodgkin Lymphoma Prognosis by Activating JAK/STAT and NF-κB Signaling Pathways

Iranian Journal of Medical Sciences
مقاله 3، دوره 49، شماره 2، اردیبهشت 2024، صفحه 88-100    اصل مقاله (4.04 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.97287.2896
نویسندگان
Mohamed Ali Alabiad* 1؛ Warda M. M. Said2؛ Rema H Faraj Saad2؛ Rawda Balata3؛ Asmaa A. Mahmoud4؛ Elsayed Anany Metwally5؛ Amany Mohamed Shalaby5؛ Walaa Samy6؛ Ahmed M. Yehia7؛ Amar Ibrahim Omar Yahia8، 9؛ Mohammed Alorini10؛ Doaa I. Abdelrahman11
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Pathology, Faculty of Medicine, University of Benghazi, Benghazi, Libya
3Department of Clinical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
5Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
6Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
7Department of General Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt
8Department of Basic Medical Sciences, College of Medicine, University of Bisha, Bisha, Saudi Arabia
9Department of Pathology, Faculty of Medicine and Health Sciences, University of Kordofan, Elobeid, Sudan
10Department of Basic Medical Sciences, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia
11Department of Pathology, Faculty of Medicine, Zagazig University, Egypt.Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
چکیده
Background: Epstein-Barr virus (EBV) is detected in 40% of patients with Hodgkin lymphoma (HL). During latency, EBV induces epigenetic alterations to the host genome and decreases the expression of pro-apoptotic proteins. The present study aimed to evaluate the expression levels of mRNA molecules and the end product of proteins for the JAK/STAT and NF-κB pathways, and their association with clinicopathological and prognostic parameters in patients with EBV-positive and -negative classical Hodgkin lymphoma (CHL).
Methods: A prospective cohort study was conducted from 2017 to 2022 at the Faculty of Medicine, Zagazig University Hospital (Zagazig, Egypt). Biopsy samples of 64 patients with CHL were divided into EBV-positive and EBV-negative groups. The expression levels of mRNA molecules (JAK2, STAT1, IRF-1, PD-L1, IFN-γ, NF-κB, Bcl-xL, COX-2) and the end product of proteins (PD-L1, Bcl-xL, COX-2) were determined and compared with clinicopathological and prognostic parameters. Data were analyzed using the Chi square test and Kaplan-Meier estimate. 
Results: EBV-positive CHL patients were significantly associated with positive expression of mRNAs molecules (P<0.001) and the end product of proteins (P<0.001) for the JAK/STAT and NF-κB pathways, B-symptoms (P=0.022), extra-nodal involvement (P=0.017), and advanced stage of CHL (P=0.018). These patients were more susceptible to cancer progression, higher incidence of relapse (P=0.008), poor disease-free survival rate (P=0.013), poor overall survival rate (P=0.028), and higher mortality rate (P=0.015).
Conclusion: Through the activation of JAK/STAT and NF-κB signaling pathways, EBV-positive CHL is associated with poor clinicopathological parameters, higher incidence of disease progression, relapse, and poor overall survival.

تازه های تحقیق

Mohamed Ali Alabiad (Google Scholar)

کلیدواژه‌ها
Hodgkin disease؛ Epstein-Barr virus infections؛ Janus kinases؛ NF kappa B
سایر فایل های مرتبط با مقاله
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