Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips | ||
| Iranian Journal of Immunology | ||
| مقاله 1، دوره 20، شماره 4، زمستان 2023، صفحه 382-399 اصل مقاله (1.28 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22034/iji.2023.98326.2567 | ||
| نویسندگان | ||
| Ali Shams* ؛ Sahar Khosravi؛ Aysan Zareiye؛ Yeganeh Lalehzari؛ Reyhane Nematollahi؛ Solmaz Basti | ||
| Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. | ||
| چکیده | ||
| Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite extensive researches on severe COVID-19 infection, the etiology and/or mechanisms of lymphopenia, decreased T cell-mediated responses in patients, cytokine release storms (CRS), and enhanced pro-inflammatory mediators are not fully understood. Several T cell subpopulations, including innate-like lymphocytes (ILLs) and conventional T cells, are involved in COVID-19 infection; however, their contribution to immunity and complications remains to be more elucidated. CD16+ T cells are among the effective players in the development of T helper1 (Th1) responses in COVID-19 infection, while their robust cytolytic properties contribute to lung tissue damage. While CD56-CD16bright NK cells play a protective role, natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells and their roles in COVID-19 require further investigation. The involvement of the other T cell subsets, such as Th17, along with neutrophils, adds to the complexity of the situation. In this review, we presented and discussed the findings of recent studies on T cell responses and the contribution of each type of immune cells to COVID-19. | ||
| کلیدواژهها | ||
| Cell-mediated Immunity؛ COVID-19؛ γδ T cells؛ Mucosal-Associated Invariant T cells؛ NKT cells؛ T helper cells | ||
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