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Shams, Ali, Khosravi, Sahar, Zareiye, Aysan, Lalehzari, Yeganeh, Nematollahi, Reyhane, Basti, Solmaz. (1402). Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips. سامانه مدیریت نشریات علمی, 20(4), 382-399. doi: 10.22034/iji.2023.98326.2567
Ali Shams; Sahar Khosravi; Aysan Zareiye; Yeganeh Lalehzari; Reyhane Nematollahi; Solmaz Basti. "Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips". سامانه مدیریت نشریات علمی, 20, 4, 1402, 382-399. doi: 10.22034/iji.2023.98326.2567
Shams, Ali, Khosravi, Sahar, Zareiye, Aysan, Lalehzari, Yeganeh, Nematollahi, Reyhane, Basti, Solmaz. (1402). 'Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips', سامانه مدیریت نشریات علمی, 20(4), pp. 382-399. doi: 10.22034/iji.2023.98326.2567
Shams, Ali, Khosravi, Sahar, Zareiye, Aysan, Lalehzari, Yeganeh, Nematollahi, Reyhane, Basti, Solmaz. Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips. سامانه مدیریت نشریات علمی, 1402; 20(4): 382-399. doi: 10.22034/iji.2023.98326.2567

Behaviors of Human T cells in SARS-CoV-2 Infection: Lessons and Tips

Iranian Journal of Immunology
مقاله 1، دوره 20، شماره 4، اسفند 2023، صفحه 382-399    اصل مقاله (1.28 M)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.98326.2567
نویسندگان
Ali Shams* ؛ Sahar Khosravi؛ Aysan Zareiye؛ Yeganeh Lalehzari؛ Reyhane Nematollahi؛ Solmaz Basti
Department of Immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
چکیده
Cell-mediated immunity (CMI) is crucial in controlling the highly aggressive and progressive SARS-CoV-2 infection. Despite extensive researches on severe COVID-19 infection, the etiology and/or mechanisms of lymphopenia, decreased T cell-mediated responses in patients, cytokine release storms (CRS), and enhanced pro-inflammatory mediators are not fully understood. Several T cell subpopulations, including innate-like lymphocytes (ILLs) and conventional T cells, are involved in COVID-19 infection; however, their contribution to immunity and complications remains to be more elucidated. CD16+ T cells are among the effective players in the development of T helper1 (Th1) responses in COVID-19 infection, while their robust cytolytic properties contribute to lung tissue damage. While CD56-CD16bright NK cells play a protective role, natural killer T (NKT) cells, mucosal-associated invariant T (MAIT) cells, and γδ T cells and their roles in COVID-19 require further investigation. The involvement of the other T cell subsets, such as Th17, along with neutrophils, adds to the complexity of the situation. In this review, we presented and discussed the findings of recent studies on T cell responses and the contribution of each type of immune cells to COVID-19.
کلیدواژه‌ها
Cell-mediated Immunity؛ COVID-19؛ γδ T cells؛ Mucosal-Associated Invariant T cells؛ NKT cells؛ T helper cells
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