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Atarbashi Moghadam, Saede, Lotfi, Ali, Eftekhari-Moghadam, Parsa. (1402). Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions. سامانه مدیریت نشریات علمی, 25(1), 91-94. doi: 10.30476/dentjods.2023.98784.2108
Saede Atarbashi Moghadam; Ali Lotfi; Parsa Eftekhari-Moghadam. "Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions". سامانه مدیریت نشریات علمی, 25, 1, 1402, 91-94. doi: 10.30476/dentjods.2023.98784.2108
Atarbashi Moghadam, Saede, Lotfi, Ali, Eftekhari-Moghadam, Parsa. (1402). 'Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions', سامانه مدیریت نشریات علمی, 25(1), pp. 91-94. doi: 10.30476/dentjods.2023.98784.2108
Atarbashi Moghadam, Saede, Lotfi, Ali, Eftekhari-Moghadam, Parsa. Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions. سامانه مدیریت نشریات علمی, 1402; 25(1): 91-94. doi: 10.30476/dentjods.2023.98784.2108

Oral Granular Cell Tumor: A Case Report with Emphasis on Pseudoepitheliomatous Hyperplasia in Oral Lesions

Journal of Dentistry
مقاله 42، دوره 25، شماره 1 - شماره پیاپی 82، خرداد 2024، صفحه 91-94    اصل مقاله (177.11 K)
نوع مقاله: Case Report
شناسه دیجیتال (DOI): 10.30476/dentjods.2023.98784.2108
نویسندگان
Saede Atarbashi Moghadam1؛ Ali Lotfi1؛ Parsa Eftekhari-Moghadam* 2
1Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2Research Center, Dental School Shahid Beheshti University of Medical Sciences, Tehran, Iran.
چکیده
A granular cell tumor (GCT) is an unusual benign mesenchymal neoplasm with Schwann cells origin. The most common site is the dorsum of the tongue. It has a striking tendency to occur in females and is more frequent in adult patients. GCT typically shows an asymptomatic, slow-growing, single nodule. Histopathologically, it reveals a proliferation of polygonal cells with granular cytoplasm penetrating the adjacent muscles. In some cases, the overlying epithelium demonstrates pseudoepitheliomatous hyperplasia (PEH), which can complicate its precise diagnosis and may mimic squamous cell carcinoma (SCC). This paper presents a 58-year-old woman with a chief complaint of painless mass on the dorsal of the tongue for two years. The lesion was pink and circumscribed with firm consistency measuring 1×1cm. The surface of the lesion was intact. Microscopic examination demonstrated unencapsulated sheets of large, polygonal cells with abundant eosinophilic, granul-ar cytoplasm, and vesicular nuclei. The overlying epithelium showed florid PEH and keratin pearl formation. S100 protein was positive diffusely. The diagnosis of oral GCT was made. Though GCT is a non-aggressive lesion, it may be confused with SCC due to florid PEH and keratin pearl formation. Although PEH is a neglected topic among oral patholog-ists, it is of great importance in the field of research. Diagnosis can sometimes be problematic because they mimic other lesions. The pathogenesis of PEH is still uncertain. Therefore, familiarity with these characteristics and determining the cause of the PEH leads to correct treatment. This article intends to raise the insight of oral pathologists about PEH in oral lesions.

تازه های تحقیق

Saede Atarbashi-Moghadam (Google Scholar)

کلیدواژه‌ها
Granular cell tumor؛ Oral cavity؛ Tongue؛ S100
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مراجع
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