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Hosseini, Sare, Bahadori, Mahshid, Tadayon, Seyed Mohammad Kazem, Bahrami, Faranak, Sasani, Mohammad Reza, Taghizadeh Kermani, Ali, Salek, Roham, Mohammadianpanah, Mohammad. (1402). Prognostic significance of tumor location on oncologic outcome of colon cancer. سامانه مدیریت نشریات علمی, 11(2), -. doi: 10.30476/acrr.2023.99916.1185
Sare Hosseini; Mahshid Bahadori; Seyed Mohammad Kazem Tadayon; Faranak Bahrami; Mohammad Reza Sasani; Ali Taghizadeh Kermani; Roham Salek; Mohammad Mohammadianpanah. "Prognostic significance of tumor location on oncologic outcome of colon cancer". سامانه مدیریت نشریات علمی, 11, 2, 1402, -. doi: 10.30476/acrr.2023.99916.1185
Hosseini, Sare, Bahadori, Mahshid, Tadayon, Seyed Mohammad Kazem, Bahrami, Faranak, Sasani, Mohammad Reza, Taghizadeh Kermani, Ali, Salek, Roham, Mohammadianpanah, Mohammad. (1402). 'Prognostic significance of tumor location on oncologic outcome of colon cancer', سامانه مدیریت نشریات علمی, 11(2), pp. -. doi: 10.30476/acrr.2023.99916.1185
Hosseini, Sare, Bahadori, Mahshid, Tadayon, Seyed Mohammad Kazem, Bahrami, Faranak, Sasani, Mohammad Reza, Taghizadeh Kermani, Ali, Salek, Roham, Mohammadianpanah, Mohammad. Prognostic significance of tumor location on oncologic outcome of colon cancer. سامانه مدیریت نشریات علمی, 1402; 11(2): -. doi: 10.30476/acrr.2023.99916.1185

Prognostic significance of tumor location on oncologic outcome of colon cancer

Iranian Journal of Colorectal Research
دوره 11، شماره 2، شهریور 2023    اصل مقاله (788.72 K)
نوع مقاله: Research/Original Article
شناسه دیجیتال (DOI): 10.30476/acrr.2023.99916.1185
نویسندگان
Sare Hosseini1؛ Mahshid Bahadori2؛ Seyed Mohammad Kazem Tadayon3؛ Faranak Bahrami4؛ Mohammad Reza Sasani5؛ Ali Taghizadeh Kermani6؛ Roham Salek7؛ Mohammad Mohammadianpanah* 8
1Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
3Colorectal Research Center Shiraz University of Medical Sciences Shiraz Iran
4Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
5Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran
6Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
7Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
8Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: A growing amount of data has indicated the possibility that tumor location may play a prognostic role in colon cancer. The present study set out to investigate the relation between the location of colon cancer (right side vs. left side) and the patient’s oncologic outcome. Methods: In this study, 654 colon cancer patients who had been treated and followed-up at three tertiary hospitals between 2005 and 2014 were included. To determine the most important independent factors of oncologic outcomes, the Cox regression multivariate analysis model used to analyze the prognostic impact of the primary tumor location and other clinical-, pathologic-, and treatment-related factors. Results: In the univariate analysis, the prognostic factors for disease-free survival (DFS) were the primary tumor stage (< 0.001), node stage (<0.001), tumor grade (P = 0.013), surgical margin status (P = 0.001), lymphatic vascular invasion (LVI) (<0.001), and perineural invasion (PNI) (<0.001). Additionally, the prognostic factors for disease-free survival (OS) were the primary tumor stage (<0.001), node stage (<0.001), tumor grade (P = 0.036), presence of LVI (<0.001), presence of PNI (<0.001), and the mucinous type (P = 0.042). However, in the multivariate analysis, the presence of LVI, T3-4 lesions, tumor grade II-III, and an advanced disease stage remained independent prognostic factors for DFS as well as OS. However, the colon cancer location was not a prognostic factor in terms of DFS or OS. Conclusion: We didn’t find tumor location as a significant prognostic factor for DFS and OS in colon cancer patients.
کلیدواژه‌ها
Colon Cancer؛ Prognosis؛ Survival؛ Tumor Location
مراجع
 

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