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Zare, Hamid, Nabavizdeh, Seyed Hesamedin, Jaladat, Amir Mohamad, Zarshenas, Mohamad Mehdi, Moghtaderi, Mozhgan, Basirat, Atefeh, Nasri, Nahid. (1402). The Added-on of Ziziphus Jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 48(6), 582-590. doi: 10.30476/ijms.2023.95531.2690
Hamid Zare; Seyed Hesamedin Nabavizdeh; Amir Mohamad Jaladat; Mohamad Mehdi Zarshenas; Mozhgan Moghtaderi; Atefeh Basirat; Nahid Nasri. "The Added-on of Ziziphus Jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial". سامانه مدیریت نشریات علمی, 48, 6, 1402, 582-590. doi: 10.30476/ijms.2023.95531.2690
Zare, Hamid, Nabavizdeh, Seyed Hesamedin, Jaladat, Amir Mohamad, Zarshenas, Mohamad Mehdi, Moghtaderi, Mozhgan, Basirat, Atefeh, Nasri, Nahid. (1402). 'The Added-on of Ziziphus Jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial', سامانه مدیریت نشریات علمی, 48(6), pp. 582-590. doi: 10.30476/ijms.2023.95531.2690
Zare, Hamid, Nabavizdeh, Seyed Hesamedin, Jaladat, Amir Mohamad, Zarshenas, Mohamad Mehdi, Moghtaderi, Mozhgan, Basirat, Atefeh, Nasri, Nahid. The Added-on of Ziziphus Jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial. سامانه مدیریت نشریات علمی, 1402; 48(6): 582-590. doi: 10.30476/ijms.2023.95531.2690

The Added-on of Ziziphus Jujube Syrup in the Treatment of Chronic Spontaneous Urticaria Resistant to Standard-Dose of Secondary-generation H1 Antihistamine: A Double-Blind Randomized Clinical Trial

Iranian Journal of Medical Sciences
مقاله 7، دوره 48، شماره 6، بهمن و اسفند 2023، صفحه 582-590    اصل مقاله (1.07 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.95531.2690
نویسندگان
Hamid Zare1، 2؛ Seyed Hesamedin Nabavizdeh* 3، 4؛ Amir Mohamad Jaladat5؛ Mohamad Mehdi Zarshenas6، 7، 8؛ Mozhgan Moghtaderi4؛ Atefeh Basirat2؛ Nahid Nasri2
1Department of Persian Medicine; School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Health System Research, Vice Chancellor of Treatment, Shiraz University of Medical Sciences, Shiraz, Iran
3Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
5Traditional Medicine and History of Medicine Research Center, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
6Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
8Traditional Medicine and Hydrotherapy Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
چکیده
Background: Although antihistamines are the first-line treatment for chronic spontaneous urticaria (CSU), 50% of patients don’t respond to standard doses. In this study, the effectiveness of Ziziphus jujube fruit syrup in combination with antihistamines was assessed in patients with CSU.
Methods: This double-blind randomized clinical trial was conducted in Shiraz between December 2019 and December 2020. 64 patients with CSU who had experienced hives for at least six weeks and did not respond to the usual treatments were enrolled in the study. They were randomly assigned to intervention and control groups using permuted block random allocation. For four weeks, the intervention group received 7.5 mL Ziziphus jujube syrup twice a day, while the control group received 7.5 mL simple jujube syrup twice a day. Both groups received cetirizine 10 mg every night. Urticaria activity score (UAS) and CU-Q2oL questionnaires were used to assess urticaria state and sleep quality before and after each week for four consecutive weeks. Data were analyzed using SPSS software version 18, and P<0.05 was considered statistically significant. 
Results: Before the intervention, there was no statistically significant difference between the two groups’ mean of UAS (P=0.490) and sleep quality (P=0.423). During the follow-up, UAS in the intervention group was significantly lower (P=0.001). Moreover, this difference was significant on the day 28 (P=0.046). During the follow-up, the quality of sleep in both groups improved significantly, and this improvement was more significant in the intervention group.
Conclusion: Ziziphus jujube syrup could be an effective adjuvant treatment for CSU.
Trial Registration Number: IRCT20190304042916N1. 

تازه های تحقیق

Hamid Zare (Google Scholar)

Seyed Hesamedin Nabavizdeh (Google Scholar)

کلیدواژه‌ها
Chronic urticaria؛ Ziziphus, jujube؛ Quality of life؛ Sleep quality
سایر فایل های مرتبط با مقاله
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