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Bagheri Lankarani, Kamran, Sadidoost, Atefeh, Fattahi, Mohammadreza, Amirizadeh Fard, Saeid, Mokarram, Pooneh. (1402). The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report. سامانه مدیریت نشریات علمی, (), -. doi: 10.30476/ijms.2023.96588.2813
Kamran Bagheri Lankarani; Atefeh Sadidoost; Mohammadreza Fattahi; Saeid Amirizadeh Fard; Pooneh Mokarram. "The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.30476/ijms.2023.96588.2813
Bagheri Lankarani, Kamran, Sadidoost, Atefeh, Fattahi, Mohammadreza, Amirizadeh Fard, Saeid, Mokarram, Pooneh. (1402). 'The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.30476/ijms.2023.96588.2813
Bagheri Lankarani, Kamran, Sadidoost, Atefeh, Fattahi, Mohammadreza, Amirizadeh Fard, Saeid, Mokarram, Pooneh. The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.30476/ijms.2023.96588.2813

The Potential Role of Autophagy in Progression of Liver Fibrosis in Chronic Hepatitis B Patients Receiving Antiviral Treatment: A Brief Report

Iranian Journal of Medical Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 20 شهریور 1402    اصل مقاله (242.25 K)
نوع مقاله: Brief Report(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.96588.2813
نویسندگان
Kamran Bagheri Lankarani1؛ Atefeh Sadidoost* 1؛ Mohammadreza Fattahi1؛ Saeid Amirizadeh Fard2؛ Pooneh Mokarram3
1Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2Gastroenterology and Hepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3Autophagy Research Center, Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Despite antiviral treatment, some patients with chronic hepatitis B (CHB) progress to cirrhosis. Enhancement of autophagy was implicated in the proliferation of hepatitis B in hepatocytes. This study aimed to evaluate the potential role of autophagy in the progression of liver fibrosis in patients receiving antiviral treatments and having completely inhibited viral replication. This descriptive-analytical study was designed and conducted in 2020 at Mottahhari Hepatitis Clinic affiliated with Shiraz University of Medical Science (Shiraz, Iran). Patients who were on anti-hepatitis B nucleotide treatments for at least two years, and those who were not cirrhotic at baseline but later  progressed to cirrhosis were identified to be included in the case group. Besides, for the control group, patients on the nucleotide regimens who did not have cirrhosis at baseline or during follow-up were randomly selected. Ultimately, 16 cases and 14 controls were included in the study. Data were analyzed using SPSS software, and P<0.05 was considered statistically significant. Serum Beclin-1 and LC3 levels were compared between the two groups using enzyme-linked immunosorbent assays. The t test was used to assess the statistical differences between the case and control groups. Beclin-1 level was significantly higher in cirrhosis patients than the control group (1283±244 vs. 1063±257, P=0.024). However, there was no statistical difference between the level of LC3 in the cirrhotic group (168±31) and the control group (150±16) (P=0.065). Autophagy may have a role in the progression of cirrhosis in patients with CHB. Future larger prospective studies are required to determine the effect of blocking on the progression of liver disease in this population.
کلیدواژه‌ها
Autophagy؛ Hepatitis B, chronic؛ Fibrosis؛ Beclin-1
مراجع
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