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Soltani, Mona, Fotovat, Reza, Sharifi, Mohsen, Ahmadian Chashmi, Najmeh, Behmanesh, Mehrdad. (1402). In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells. سامانه مدیریت نشریات علمی, 49(1), 30-39. doi: 10.30476/ijms.2023.94805.2611
Mona Soltani; Reza Fotovat; Mohsen Sharifi; Najmeh Ahmadian Chashmi; Mehrdad Behmanesh. "In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells". سامانه مدیریت نشریات علمی, 49, 1, 1402, 30-39. doi: 10.30476/ijms.2023.94805.2611
Soltani, Mona, Fotovat, Reza, Sharifi, Mohsen, Ahmadian Chashmi, Najmeh, Behmanesh, Mehrdad. (1402). 'In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells', سامانه مدیریت نشریات علمی, 49(1), pp. 30-39. doi: 10.30476/ijms.2023.94805.2611
Soltani, Mona, Fotovat, Reza, Sharifi, Mohsen, Ahmadian Chashmi, Najmeh, Behmanesh, Mehrdad. In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells. سامانه مدیریت نشریات علمی, 1402; 49(1): 30-39. doi: 10.30476/ijms.2023.94805.2611

In Vitro Comparative Study on Antineoplastic Effects of Pinoresinol and Lariciresinol on Healthy Cells and Breast Cancer-Derived Human Cells

Iranian Journal of Medical Sciences
مقاله 4، دوره 49، شماره 1، فروردین 2024، صفحه 30-39    اصل مقاله (3.13 M)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2023.94805.2611
نویسندگان
Mona Soltani1، 2؛ Reza Fotovat1؛ Mohsen Sharifi3؛ Najmeh Ahmadian Chashmi4؛ Mehrdad Behmanesh* 2
1Department of Plant Production and Genetics, School of Agriculture, University of Zanjan, Zanjan, Iran
2Department of Genetics, School of Biological Sciences, Tarbiat Modares University, Tehran, Iran
3Department of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
4Interfaculty Institute of Biochemistry, Hoppe-Seyler-Str. 4, 72076, Tübingen, Germany
چکیده
Background: Herbal medicines are the preferred anticancer agents due to their lower cytotoxic effects on healthy cells. Plant lignans play an important role in treating various diseases, especially cancer. The present study aimed to evaluate the effect of podophyllotoxin, pinoresinol, and lariciresinol on cellular toxicity and inducing apoptosis in fibroblasts, HEK-293, and SkBr3 cell lines.
Methods: An in vitro study was conducted from 2017 to 2019 at the Faculty of Biological Sciences, Tarbiat Modares University (Tehran, Iran). The cell lines were treated for 24 and 48 hours with different concentrations of lignans. Cell viability and apoptosis were examined using MTT and flow cytometry, respectively. Expression levels of cell cycle and apoptosis regulator genes were determined using quantitative real-time polymerase chain reaction. Data were analyzed using a two-way analysis of variance followed by Tukey’s HSD test. P<0.05 was considered statistically significant.
Results: Podophyllotoxin significantly increased apoptosis in fibroblast cells compared to pinoresinol and lariciresinol (P<0.001). The percentage of cell viability of fibroblast cells treated for 48 hours with pinoresinol, lariciresinol, and podophyllotoxin was reduced by 49%, 47%, and 36%, respectively. Treatment with pinoresinol and lariciresinol significantly overexpressed pro-apoptotic genes and underexpressed anti-apoptotic genes in SkBr3 cells (P<0.001). SkBr3 cells treated with lariciresinol significantly reduced gene expression (P<0.001). 
Conclusion: Pinoresinol and lariciresinol can potentially be used as new therapeutic agents for the treatment of breast cancer.

تازه های تحقیق

Mona Soltani (Google Scholar)

Mehrdad Behmanesh (Google Scholar)

کلیدواژه‌ها
Lignans؛ Natural products؛ Breast neoplasms؛ Cell viability؛ Apoptosis
سایر فایل های مرتبط با مقاله
مراجع
  1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394-424. doi: 10.3322/caac.21492. PubMed PMID: 30207593.
  2. You W, Henneberg M. Cancer incidence increasing globally: The role of relaxed natural selection. Evol Appl. 2018;11:140-52. doi: 10.1111/eva.12523. PubMed PMID: 29387151; PubMed Central PMCID: PMCPMC5775494.
  3. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209-49. doi: 10.3322/caac.21660. PubMed PMID: 33538338.
  4. Abdulridha MK, Al-Marzoqi AH, Al-Awsi GRL, Mubarak SMH, Heidarifard M, Ghasemian A. Anticancer Effects of Herbal Medicine Compounds and Novel Formulations: a Literature Review. J Gastrointest Cancer. 2020;51:765-73. doi: 10.1007/s12029-020-00385-0. PubMed PMID: 32140897.
  5. Stoff JA. Selected Office Based Anticancer Treatment Strategies. J Oncol. 2019;2019:7462513. doi: 10.1155/2019/7462513. PubMed PMID: 30766601; PubMed Central PMCID: PMCPMC6350558.
  6. El Omari N, Bakha M, Imtara H, Guaouguaoua FE, Balahbib A, Zengin G, et al. Anticancer mechanisms of phytochemical compounds: focusing on epigenetic targets. Environ Sci Pollut Res Int. 2021;28:47869-903. doi: 10.1007/s11356-021-15594-8. PubMed PMID: 34308524.
  7. Akbari Asl E, Fallah Mehrabadi J, Afshar D, Noorbazargan H, Tahmasebi H, Rahimi A. Apoptotic Effects of Linum album Extracts on AGS Human Gastric Adenocarcinoma Cells and ZNF703 Oncogene Expression. Asian Pac J Cancer Prev. 2018;19:2911-6. doi: 10.22034/APJCP.2018.19.10.2911. PubMed PMID: 30362321; PubMed Central PMCID: PMCPMC6291028.
  8. Majdalawieh AF, Mansour ZR. Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action. Eur J Pharmacol. 2019;855:75-89. doi: 10.1016/j.ejphar.2019.05.008. PubMed PMID: 31063773.
  9. Bowers LW, Lineberger CG, Ford NA, Rossi EL, Punjala A, Camp KK, et al. The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFkappaB signaling, and inhibits mammary tumor growth. Breast Cancer Res Treat. 2019;173:545-57. doi: 10.1007/s10549-018-5021-6. PubMed PMID: 30367332; PubMed Central PMCID: PMCPMC6394576.
  10. Gaya P, Medina M, Sanchez-Jimenez A, Landete JM. Phytoestrogen Metabolism by Adult Human Gut Microbiota. Molecules. 2016;21. doi: 10.3390/molecules21081034. PubMed PMID: 27517891; PubMed Central PMCID: PMCPMC6274073.
  11. Lecomte S, Demay F, Ferriere F, Pakdel F. Phytochemicals Targeting Estrogen Receptors: Beneficial Rather Than Adverse Effects? Int J Mol Sci. 2017;18. doi: 10.3390/ijms18071381. PubMed PMID: 28657580; PubMed Central PMCID: PMCPMC5535874.
  12. Kuo HJ, Wei ZY, Lu PC, Huang PL, Lee KT. Bioconversion of pinoresinol into matairesinol by use of recombinant Escherichia coli. Appl Environ Microbiol. 2014;80:2687-92. doi: 10.1128/AEM.03397-13. PubMed PMID: 24561584; PubMed Central PMCID: PMCPMC3993289.
  13. Zhou H, Lv S, Zhang D, Deng M, Zhang X, Tang Z, et al. A polypeptide based podophyllotoxin conjugate for the treatment of multi drug resistant breast cancer with enhanced efficiency and minimal toxicity. Acta Biomater. 2018;73:388-99. doi: 10.1016/j.actbio.2018.04.016. PubMed PMID: 29694920.
  14. Zhao W, Cong Y, Li HM, Li S, Shen Y, Qi Q, et al. Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy. Nat Prod Rep. 2021;38:470-88. doi: 10.1039/d0np00041h. PubMed PMID: 32895676.
  15. Ahmadian Chashmi N, Sharifi M, Behmanesh M. Lignan enhancement in hairy root cultures of Linum album using coniferaldehyde and methylenedioxycinnamic acid. Prep Biochem Biotechnol. 2016;46:454-60. doi: 10.1080/10826068.2015.1068802. PubMed PMID: 26444150.
  16. Martelli Chaib Saliba AS, Giovanini de Oliveira Sartori A, Souza Batista P, Pedroso Gomes do Amaral JE, Oliveira da Silva N, Ikegaki M, et al. Simulated gastrointestinal digestion/Caco-2 cell transport: Effects on biological activities and toxicity of a Brazilian propolis. Food Chem. 2023;403:134330. doi: 10.1016/j.foodchem.2022.134330. PubMed PMID: 36182853.
  17. Pozzetti L, Ferrara F, Marotta L, Gemma S, Butini S, Benedusi M, et al. Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals. Antioxidants (Basel). 2022;11. doi: 10.3390/antiox11030437. PubMed PMID: 35326088; PubMed Central PMCID: PMCPMC8944769.
  18. McGrowder DA, Miller FG, Nwokocha CR, Anderson MS, Wilson-Clarke C, Vaz K, et al. Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action. Medicines (Basel). 2020;7. doi: 10.3390/medicines7080047. PubMed PMID: 32823812; PubMed Central PMCID: PMCPMC7460502.
  19. Ma ZJ, Lu L, Yang JJ, Wang XX, Su G, Wang ZL, et al. Lariciresinol induces apoptosis in HepG2 cells via mitochondrial-mediated apoptosis pathway. Eur J Pharmacol. 2018;821:1-10. doi: 10.1016/j.ejphar.2017.12.027. PubMed PMID: 29247613.
  20. Pfeffer CM, Singh ATK. Apoptosis: A Target for Anticancer Therapy. Int J Mol Sci. 2018;19. doi: 10.3390/ijms19020448. PubMed PMID: 29393886; PubMed Central PMCID: PMCPMC5855670.
  21. Bagheri E, Hajiaghaalipour F, Nyamathulla S, Salehen N. The apoptotic effects of Brucea javanica fruit extract against HT29 cells associated with p53 upregulation and inhibition of NF-kappaB translocation. Drug Des Devel Ther. 2018;12:657-71. doi: 10.2147/DDDT.S155115. PubMed PMID: 29636600; PubMed Central PMCID: PMCPMC5881282.
  22. Kiraz Y, Adan A, Kartal Yandim M, Baran Y. Major apoptotic mechanisms and genes involved in apoptosis. Tumour Biol. 2016;37:8471-86. doi: 10.1007/s13277-016-5035-9. PubMed PMID: 27059734.
  23. Changxing L, Galani S, Hassan FU, Rashid Z, Naveed M, Fang D, et al. Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview. Biomed Pharmacother. 2020;132:110918. doi: 10.1016/j.biopha.2020.110918. PubMed PMID: 33254434.
  24. Tannous S, Haykal T, Dhaini J, Hodroj MH, Rizk S. The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells. Biomed Pharmacother. 2020;132:110884. doi: 10.1016/j.biopha.2020.110884. PubMed PMID: 33080470.
  25. Jang WY, Kim MY, Cho JY. Antioxidant, Anti-Inflammatory, Anti-Menopausal, and Anti-Cancer Effects of Lignans and Their Metabolites. Int J Mol Sci. 2022;23. doi: 10.3390/ijms232415482. PubMed PMID: 36555124; PubMed Central PMCID: PMCPMC9778916.
  26. Medeiros B, Allan AL. Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives. Int J Mol Sci. 2019;20. doi: 10.3390/ijms20092272. PubMed PMID: 31071959; PubMed Central PMCID: PMCPMC6540248.
  27. Zheng T, Wang A, Hu D, Wang Y. Molecular mechanisms of breast cancer metastasis by gene expression profile analysis. Mol Med Rep. 2017;16:4671-7. doi: 10.3892/mmr.2017.7157. PubMed PMID: 28791367; PubMed Central PMCID: PMCPMC5647040.
  28. Jan R, Chaudhry GE. Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics. Adv Pharm Bull. 2019;9:205-18. doi: 10.15171/apb.2019.024. PubMed PMID: 31380246; PubMed Central PMCID: PMCPMC6664112.
  29. Ke FS, Holloway S, Uren RT, Wong AW, Little MH, Kluck RM, et al. The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK. EMBO J. 2022;41:e110300. doi: 10.15252/embj.2021110300. PubMed PMID: 35758142; PubMed Central PMCID: PMCPMC9340487.
  30. Rafat A, Dizaji Asl K, Mazloumi Z, Movassaghpour AA, Talebi M, Shanehbandi D, et al. Telomerase inhibition on acute myeloid leukemia stem cell induced apoptosis with both intrinsic and extrinsic pathways. Life Sci. 2022;295:120402. doi: 10.1016/j.lfs.2022.120402. PubMed PMID: 35176279.
  31. Gupta A, Shah K, Oza MJ, Behl T. Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatment. Biomed Pharmacother. 2019;109:484-92. doi: 10.1016/j.biopha.2018.10.155. PubMed PMID: 30551517.
  32. Li M. The role of P53 up-regulated modulator of apoptosis (PUMA) in ovarian development, cardiovascular and neurodegenerative diseases. Apoptosis. 2021;26:235-47. doi: 10.1007/s10495-021-01667-z. PubMed PMID: 33783663; PubMed Central PMCID: PMCPMC8197724.
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