|تعداد مشاهده مقاله||12,896,280|
|تعداد دریافت فایل اصل مقاله||6,144,851|
Investigation of Serum PIVKA-II Levels in Patients with Helicobacter pylori Infection and Normal Group
|Iranian Journal of Colorectal Research|
|دوره 11، شماره 2، شهریور 2023 اصل مقاله (721.79 K)|
|نوع مقاله: Research/Original Article|
|شناسه دیجیتال (DOI): 10.30476/acrr.2023.99923.1184|
|Seyedeh Azra Shamsdin* 1؛ Hassan Akrami2؛ yousef Nikmanesh3؛ hasti samani4؛ mohammadjavad Fattahi* 5|
|1Gasteroenterohepatology Research Center Shiraz University of Medical Sciences Shiraz, Iran|
|2Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranShiraz|
|3Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Fars, Shiraz, Iran|
|4Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran|
|5Institute for Cancer Research, Shiraz University of Medical Science, Shiraz, Iran|
Background: Helicobacter pylori is one of the most common microorganisms known in humans, and as a risk factor it can result in gastric cancer, therefore we decided to evaluate the serum level of PIVKA-II in patients with Helicobacter pylori (H. pylori) infection and normal group.
Materials and Methods: This study was performed on 90 patients (45 patients with H. pylori infection and 45 patients in the control group). After recording demographic information, serum level of PIVKA-II was measured in two groups by ELISA method.
Results: The findings of our study showed no significant difference between the serum level of PIVKA-II in patients with H. pylori compared to those without infection (p = 0.08) but at the age of less than 40 years, the mean serum level of PIVKA-II in patients with H. pylori was significantly lower than the control group (p = 0.026), Also in men infected by H. pylori the mean serum level of PIVKA-II was significantly less than the control group. (p = 0.04)
Conclusion: The results of the present study indicate that the serum level of PIVKA-II in infected men as well as in people under 40 years of age with H. pylori infection, was significantly lower than the control group. Also, serum PIVKA-II levels in patients were significantly lower in men than women and in those under 40 years of age compared with those over 40 years of age.
|Helicobacter pylori؛ PIVKA-II؛ Gastritis؛ Infection|
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