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Rahmani, Baranoosh, Shahbazi-Gahrouei, Daryoush, Roayaei, Mahnaz. (1402). Evaluating the Effect of Co-Registered Diagnostic MR Images based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer. سامانه مدیریت نشریات علمی, (), -. doi: 10.31661/jbpe.v0i0.2301-1580
Baranoosh Rahmani; Daryoush Shahbazi-Gahrouei; Mahnaz Roayaei. "Evaluating the Effect of Co-Registered Diagnostic MR Images based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer". سامانه مدیریت نشریات علمی, , , 1402, -. doi: 10.31661/jbpe.v0i0.2301-1580
Rahmani, Baranoosh, Shahbazi-Gahrouei, Daryoush, Roayaei, Mahnaz. (1402). 'Evaluating the Effect of Co-Registered Diagnostic MR Images based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.31661/jbpe.v0i0.2301-1580
Rahmani, Baranoosh, Shahbazi-Gahrouei, Daryoush, Roayaei, Mahnaz. Evaluating the Effect of Co-Registered Diagnostic MR Images based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer. سامانه مدیریت نشریات علمی, 1402; (): -. doi: 10.31661/jbpe.v0i0.2301-1580

Evaluating the Effect of Co-Registered Diagnostic MR Images based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer

Journal of Biomedical Physics and Engineering
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 13 شهریور 1402    اصل مقاله (824.29 K)
نوع مقاله: Original Research
شناسه دیجیتال (DOI): 10.31661/jbpe.v0i0.2301-1580
نویسندگان
Baranoosh Rahmani1؛ Daryoush Shahbazi-Gahrouei* 1؛ Mahnaz Roayaei2
1Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Radiation Oncology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background: Magnetic Resonance Imaging (MRI) has become a complementary imaging method for the treatment planning process due to the limitations of Computed Tomography (CT) imaging. 
Objective: This study aimed to assess the effect of co-registered MRI and CT (MRI/CT)-based target delineation on the dose to the target, small bowel, bladder, and femoral heads during Helical Tomotherapy (HT).
Material and Methods: In this cross-sectional prospective study, MRI in a prone position were obtained for 12 patients with rectal cancer at one-day intervals with simulation CT. Following the co-registration process with the deformable 
algorithm, target volumes are defined. Gross Tumor Volume (GTV), Clinical Target Volume (CTV), and Planning Target Volume (PTV) were delineated for each CT and MRI/CT. 
Results: GTV, CTV, and PTV mean values were significantly higher in the CT-based target delineation method than those in the MRI/CT-based method. In MRI/CT-based plans, the mean HI value was significantly lower, and the mean Conformity Index (CI) value was significantly higher than that in CT-based plans. In a small bowl, the most of dosimetric parameters (Dmax, Dmean, D50%, D50%, V40%, and V45%) were significantly higher for the CT-based plans. In the bladder, all dosimetric parameters, except V30%, were statistically higher in CT-based plans.  
Conclusion: Co-registered MRI/CT-based treatment planning can produce 
better dose coverage for the target and reduce the delivered dose to the Organs at Risk (OARs) when compared to CT-based planning.
کلیدواژه‌ها
Magnetic Resonance Imaging؛ Computed Tomography؛ Rectal Neoplasms؛ Radiotherapy؛ Helical Tomotherapy
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