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Mashhadi, Niloofar, Kasraian, Leila, Ghoddusi Johari, Hamed, Hosseinzadeh, Ahmad, Kheshtchin, Nasim, Doroudchi, Mehrnoosh. (1402). Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans. سامانه مدیریت نشریات علمی, 20(3), 262-275. doi: 10.22034/iji.2023.99188.2622
Niloofar Mashhadi; Leila Kasraian; Hamed Ghoddusi Johari; Ahmad Hosseinzadeh; Nasim Kheshtchin; Mehrnoosh Doroudchi. "Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans". سامانه مدیریت نشریات علمی, 20, 3, 1402, 262-275. doi: 10.22034/iji.2023.99188.2622
Mashhadi, Niloofar, Kasraian, Leila, Ghoddusi Johari, Hamed, Hosseinzadeh, Ahmad, Kheshtchin, Nasim, Doroudchi, Mehrnoosh. (1402). 'Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans', سامانه مدیریت نشریات علمی, 20(3), pp. 262-275. doi: 10.22034/iji.2023.99188.2622
Mashhadi, Niloofar, Kasraian, Leila, Ghoddusi Johari, Hamed, Hosseinzadeh, Ahmad, Kheshtchin, Nasim, Doroudchi, Mehrnoosh. Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans. سامانه مدیریت نشریات علمی, 1402; 20(3): 262-275. doi: 10.22034/iji.2023.99188.2622

Senescent CD153+ T Lymphocytes Increase in the Peripheral Blood of Patients with Thromboangiitis Obliterans

Iranian Journal of Immunology
دوره 20، شماره 3، آذر 2023، صفحه 262-275    اصل مقاله (2.66 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.99188.2622
نویسندگان
Niloofar Mashhadi1؛ Leila Kasraian2؛ Hamed Ghoddusi Johari3؛ Ahmad Hosseinzadeh3؛ Nasim Kheshtchin1؛ Mehrnoosh Doroudchi* 1، 4
1Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
2Blood Transfusion Research Center, High Institute for Education and Research, Shiraz, Iran.
3Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4Immunology Center for Excellence, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
چکیده
Background: Buerger’s disease, also known as Thromboangiitis Obliterans (TAO), is a progressive, inflammatory vascular disease with unknown etiology.
Objective: To address the degree of T cell immunosenescence in this inflammatory disease, the frequency of senescent T cells expressing CD57 and/or CD153 (CD30L) in patients with TAO.
Methods: In this study, nine male cigarette smoker patients with TAO, nine male healthy cigarette smokers, and nine male healthy non-smoker blood donors were enrolled. PBMCs were extracted from the blood of all participants and stored in liquid nitrogen before use. The percentages of senescent T cells were detected by flow cytometry. The results were analyzed using non-parametric statistical tests.
Results: The frequencies of senescent CD3+CD4+CD57+CD153+ and CD3+CD4+CD57-CD153+ T cells significantly increased in patients compared with the non-smoker controls (p=0.01 and p=0.04, respectively). The frequency of senescent CD3+CD4-CD57-CD153+ T cells was higher in patients compared with the smoker controls (p=0.02). In patients with TAO, CD57+CD153- cells were more frequent in CD3hiCD4- and CD3hiCD4+ T cells compared with the CD3loCD4- and CD3loCD4+ T cells (p=0.008 and p=0.0002, respectively). Conversely, the frequency of CD57-CD153+ T cells was significantly higher in CD3loCD4- T cells compared with the CD3hiCD4- T cells (p=0.004). The percentage of CD3+CD4+CD57+CD153- T cells correlated negatively with smoking level in smoker controls (p=0.02, Spearman r=-0.80).
Conclusion: Elevated frequencies of senescent CD4+CD57+CD153+ and CD4+CD57-CD153+ T cells in patients compared with non-smoker and smoker controls suggest the contribution of immunosenescence in TAO.
کلیدواژه‌ها
CD57؛ CD153/CD30L؛ Cigarette Smoking؛ Immunosenescence؛ Thromboangiitis Obliterans
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