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Zangeneh, Zivar, Khamisipour, Gholamreza. (1402). Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease. سامانه مدیریت نشریات علمی, 20(3), 368-373. doi: 10.22034/iji.2023.97202.2488
Zivar Zangeneh; Gholamreza Khamisipour. "Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease". سامانه مدیریت نشریات علمی, 20, 3, 1402, 368-373. doi: 10.22034/iji.2023.97202.2488
Zangeneh, Zivar, Khamisipour, Gholamreza. (1402). 'Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease', سامانه مدیریت نشریات علمی, 20(3), pp. 368-373. doi: 10.22034/iji.2023.97202.2488
Zangeneh, Zivar, Khamisipour, Gholamreza. Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease. سامانه مدیریت نشریات علمی, 1402; 20(3): 368-373. doi: 10.22034/iji.2023.97202.2488

Elevated HSP70 and HSP90 as Predictive Markers of Immune Activation and Lung Injury in SARS-COV-2 Disease

Iranian Journal of Immunology
دوره 20، شماره 3، آذر 2023، صفحه 368-373    اصل مقاله (429.44 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22034/iji.2023.97202.2488
نویسندگان
Zivar Zangeneh؛ Gholamreza Khamisipour*
Department of Hematology, School of Para Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
چکیده
Background: Heat shock proteins (HSPs) are involved in innate and adaptive immune responses, especially inflammatory responses due to immune cell activation. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was one of the most important causes of death in the recent pandemic. Increased cellular stress and excessive inflammation are common in coronavirus disease-19 (COVID-19), although the underlying mechanisms are still poorly
understood.
Objective: To evaluate the relationship between HSP and the pathological effects of COVID-19.
Methods: A group of 107 patients was categorized to two populations (mild and severe) based on their chest high-resolution computed tomography (HRCT) results. The HSP70, HSP90 alpha, and serum levels of C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay (ELISA). Lactate dehydrogenase (LDH), and creatine phosphokinase (CPK) were measured by the automated analyzer.
Results: Our data showed increased levels of HSP70 and HSP90 in patients with COVID-19. The HSPs levels were elevated in the severe group compared to the mild group. This study demonstrated a positive correlation between both elevated levels of HSP70, HSP90, and HRCT grade and also a positive correlation with CRP and CPK in the severe group.
Conclusion: HSP90 and HSP70 contribute to excessive immune responses and cytokine storms. They may serve as prognostic serum markers for COVID-19 lung injury. Additionally, they are
candidates for anti-inflammatory therapy.
کلیدواژه‌ها
COVID-19؛ C-Reactive Protein؛ Heat Shock Proteins؛ Inflammation؛ Pulmonary
مراجع
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