Where Do Liver Injuries Stand in the Post-COVID-19 Era? A Review of the Connection between Long COVID and Liver Diseases | ||
| Iranian Journal of Colorectal Research | ||
| مقاله 1، دوره 11، شماره 1، بهار 2023، صفحه 1-14 اصل مقاله (1.86 M) | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.30476/acrr.2023.98911.1179 | ||
| نویسندگان | ||
| Somayeh Igder1؛ Mozhdeh Zamani2، 3؛ Omid Vakili4؛ Morvarid Siri2؛ Mojtaba Rashidi1؛ Seyed Vahid Hosseini5؛ Pooneh Mokarram* 6 | ||
| 1Department of Clinical Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran | ||
| 2Autophagy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 3Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 4Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran | ||
| 5Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| 6Autophagy Research Center, Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran | ||
| چکیده | ||
| The coronavirus disease 2019 (COVID-19) pandemic threatened public health globally. Some patients who recover from the initial infection develop persistent symptoms and organ dysfunction for weeks or even months, called long COVID. Among multiple COVID-19-related complications, individuals may suffer from intrahepatic and extrahepatic complications principally mediated by ACE2 receptors. We reviewed PubMed, Google Scholar, and Web of Science manuscripts on underlying COVID-19-linked clinical relevance and potential pathogenesis of liver complications during short and long COVID with no time limitation. Liver impairment needs a large- scale and persistent follow-up as it may be multifactorial. During COVID-19, physicians must assess whether hepatopathy is associated with hepatic disorders, medications utilized for COVID-19 therapy, or viral antigenic outcomes progression to a complicated course. In the context of COVID-19, physicians report that potential pathophysiological approaches to hepatic failure in critical patients could lead to deep vein thrombosis, myocardial infarction, venous thromboembolism, and acute kidney injury. These complications might be either reversible or irreversible, with extended manifestations that mostly occur due to long COVID in the post- COVID era. Moreover, pre-existing cardiovascular and digestive tract problems correlate with adverse clinical outcomes and the highest fatality rate. Potential drug-disease interactions adversely influencing COVID-19 subjects and persistent comorbidities must also be considered. Besides the upshot of exiting hepatic-associated comorbidities, the effect of non-fatal and endothelial liver lesions on outcomes of COVID-19 patients remains elusive and must be investigated further. Measures to protect against hepatic toxicity should be considered when managing COVID-19 patients. | ||
| کلیدواژهها | ||
| COVID-19؛ Liver Failure؛ Post-Acute COVID-19 Syndrome | ||
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