|تعداد مشاهده مقاله||12,902,921|
|تعداد دریافت فایل اصل مقاله||6,147,647|
CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer
|Iranian Journal of Immunology|
|دوره 20، شماره 3، آذر 2023، صفحه 276-286 اصل مقاله (3.9 M)|
|نوع مقاله: Original Article|
|شناسه دیجیتال (DOI): 10.22034/iji.2023.97037.2527|
|Kuo Zhao1، 2؛ Dongmei Han3، 4؛ Lu Tang5؛ Hao Jin* 3، 4|
|1Oncology Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|
|2Oncology Department, Tianjin Cancer Hospital Airport Hospital, Tianjin, China.|
|3Center for Precision Cancer Medicine and Translational Research, Tianjin Cancer Hospital Airport Hospital, Tianjin, China.|
|4Center for Precision Cancer Medicine and Translational Research, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.|
|5Division of Rheumatology, Tianjin First Center Hospital, Tianjin, China.|
|Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.|
Objective: To analyze the relationship between the CD39 expression and clinicopathological characteristics including FIGO stage, lymph node and distant metastasis, and to further explore its potential role in cervical cancer.
Methods: Peripheral blood was collected from 59 healthy people and 43 patients with cervical cancer. The percentage and absolute counts of CD3-positive, CD4-positive and CD8-positive T lymphocytes, CD4/CD8 ratio and the percentage of the CD39+ T cells in T lymphocytes were assessed by flow cytometry, and their correlations with clinical parameters were analyzed.
Results: Absolute numbers of CD8+ T lymphocytes, CD4/CD8 ratios, and the percentage of the CD39+ T cells were linked with FIGO stage, lymph node metastasis, and distant metastasis. The total numbers of CD8+ T lymphocytes were significantly higher in the peripheral blood of patients with cervical cancer in the early and middle stages than in the advanced stage. In addition, patients with early and middle-stage cervical cancer had considerably lower percentage of CD4+ CD39 + and CD8 + CD39 + T lymphocytes than those with advanced cervical cancer.
Conclusion: These results suggest that the absolute counts of CD8+ T lymphocytes may be associated with the patient’s prognosis and that the CD39 molecule, expressed on the surface of CD8+ T cells, is also related to FIGO stage, lymph node metastasis, and distant metastasis. CD39 expression on CD8-positive T cells exhibits a negative correlation with the number of CD8-positive T lymphocytes.
|CD39 Antigen؛ Ectonucleoside Triphosphate Diphosphohydrolase 1؛ Flow Cytometry؛ T Lymphocyte Subsets؛ Uterine Cervical Neoplasms|
تعداد مشاهده مقاله: 614
تعداد دریافت فایل اصل مقاله: 415