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Zhao, Kuo, Han, Dongmei, Tang, Lu, Jin, Hao. (1402). CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer. سامانه مدیریت نشریات علمی, 20(3), 276-286. doi: 10.22034/iji.2023.97037.2527
Kuo Zhao; Dongmei Han; Lu Tang; Hao Jin. "CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer". سامانه مدیریت نشریات علمی, 20, 3, 1402, 276-286. doi: 10.22034/iji.2023.97037.2527
Zhao, Kuo, Han, Dongmei, Tang, Lu, Jin, Hao. (1402). 'CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer', سامانه مدیریت نشریات علمی, 20(3), pp. 276-286. doi: 10.22034/iji.2023.97037.2527
Zhao, Kuo, Han, Dongmei, Tang, Lu, Jin, Hao. CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer. سامانه مدیریت نشریات علمی, 1402; 20(3): 276-286. doi: 10.22034/iji.2023.97037.2527

CD39 Expression in Peripheral T Cells is Associated with Clinicopathological Characteristics in Patients with Cervical Cancer

Iranian Journal of Immunology
دوره 20، شماره 3، آذر 2023، صفحه 276-286    اصل مقاله (3.9 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.97037.2527
نویسندگان
Kuo Zhao1، 2؛ Dongmei Han3، 4؛ Lu Tang5؛ Hao Jin* 3، 4
1Oncology Department, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
2Oncology Department, Tianjin Cancer Hospital Airport Hospital, Tianjin, China.
3Center for Precision Cancer Medicine and Translational Research, Tianjin Cancer Hospital Airport Hospital, Tianjin, China.
4Center for Precision Cancer Medicine and Translational Research, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
5Division of Rheumatology, Tianjin First Center Hospital, Tianjin, China.
چکیده
Background: CD39 is an inhibitory checkpoint exerting rate-limiting effects on the ATP-adenosine pathway. It can be targeted to block adenosine-mediated immunosuppression.
Objective: To analyze the relationship between the CD39 expression and clinicopathological characteristics including FIGO stage, lymph node and distant metastasis, and to further explore its potential role in cervical cancer.
Methods: Peripheral blood was collected from 59 healthy people and 43 patients with cervical cancer. The percentage and absolute counts of CD3-positive, CD4-positive and CD8-positive T lymphocytes, CD4/CD8 ratio and the percentage of the CD39+ T cells in T lymphocytes were assessed by flow cytometry, and their correlations with clinical parameters were analyzed.
Results: Absolute numbers of CD8+ T lymphocytes, CD4/CD8 ratios, and the percentage of the CD39+ T cells were linked with FIGO stage, lymph node metastasis, and distant metastasis. The total numbers of CD8+ T lymphocytes were significantly higher in the peripheral blood of patients with cervical cancer in the early and middle stages than in the advanced stage. In addition, patients with early and middle-stage cervical cancer had considerably lower percentage of CD4+ CD39 + and CD8 + CD39 + T lymphocytes than those with advanced cervical cancer.
Conclusion: These results suggest that the absolute counts of CD8+ T lymphocytes may be associated with the patient’s prognosis and that the CD39 molecule, expressed on the surface of CD8+ T cells, is also related to FIGO stage, lymph node metastasis, and distant metastasis. CD39 expression on CD8-positive T cells exhibits a negative correlation with the number of CD8-positive T lymphocytes.
کلیدواژه‌ها
CD39 Antigen؛ Ectonucleoside Triphosphate Diphosphohydrolase 1؛ Flow Cytometry؛ T Lymphocyte Subsets؛ Uterine Cervical Neoplasms
مراجع
  1. Yang L, Zheng R, Wang N, Yuan Y, Liu S, Li H, et al. Incidence and mortality of stomach cancer in China, 2014. Chin J Cancer Res. 2018;30(3):291-8.
  2. Diefenbach D, Greten HJ, Efferth T. Genomic landscape analyses in cervical carcinoma and consequences for treatment. Curr Opin Pharmacol. 2020;54:142-57.
  3. Fahmi T, Esendagli G, Yilmaz G, Kansu E, Guc D. Immune compartmentalization of T cell subsets in chemically-induced breast cancer. Scand J Immunol. 2010;72(4):339-48.
  4. Yoshimura K, Laird LS, Chia CY, Meckel KF, Slansky JE, Thompson JM, et al. Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells. Cancer Res. 2007;67(20):10058-66.
  5. Kumar S, Paiva B, Anderson KC, Durie B, Landgren O, Moreau P, et al. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Lancet Oncol. 2016;17(8):e328-e46.
  6. Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991-8.
  7. Xia Y, Li W, Li Y, Liu Y, Ye S, Liu A, et al. The clinical value of the changes of peripheral lymphocyte subsets absolute counts in patients with non-small cell lung cancer. Transl Oncol. 2020;13(12):100849.
  8. Showe MK, Kossenkov AV, Showe LC. The peripheral immune response and lung cancer prognosis. Oncoimmunology. 2012;1(8):1414-6.
  9. Allard B, Longhi MS, Robson SC, Stagg J. The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev. 2017;276(1):121-44.
  10. Magid-Bernstein JR, Rohowsky-Kochan CM. Human CD39(+) Treg Cells Express Th17-Associated Surface Markers and Suppress IL-17 via a Stat3-Dependent Mechanism. J Interferon Cytokine Res. 2017;37(4):153-64.
  11. Bai A, Robson S. Beyond ecto-nucleotidase: CD39 defines human Th17 cells with CD161. Purinergic Signal. 2015;11(3):317-9.
  12. Figueiro F, Muller L, Funk S, Jackson EK, Battastini AM, Whiteside TL. Phenotypic and functional characteristics of CD39(high) human regulatory B cells (Breg). Oncoimmunology. 2016;5(2):e1082703.
  13. Tondell A, Wahl SGF, Sponaas AM, Sorhaug S, Borset M, Haug M. Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non-small-cell Lung Cancer. Transl Oncol. 2020;13(1):17-24.
  14. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883-99.
  15. Yang F, Jin H, Wang J, Sun Q, Yan C, Wei F, et al. Adoptive Cellular Therapy (ACT) for Cancer Treatment. Adv Exp Med Biol. 2016;909:169-239.
  16. Jin H, Sun L, Tang L, Yu W, Li H. Expression of GARP Is Increased in Tumor-Infiltrating Regulatory T Cells and Is Correlated to Clinicopathology of Lung Cancer Patients. Front Immunol. 2017;8:138.
  17. Wang YY, Zhou N, Liu HS, Gong XL, Zhu R, Li XY, et al. Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression. Cancer Med. 2020;9(14):5086-94.
  18. Li N, Zhang L, Song HL, Zhang J, Weng HW, Zou LQ. Prognostic impact of absolute lymphocyte count/absolute monocyte count ratio and prognostic score in patients with nasal-type, extranodal natural killer/T-cell lymphoma. Tumour Biol. 2017;39(5):1010428317705503.
  19. Kuss I, Hathaway B, Ferris RL, Gooding W, Whiteside TL. Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2004;10(11):3755-62.
  20. Milne K, Alexander C, Webb JR, Sun W, Dillon K, Kalloger SE, et al. Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes. J Transl Med. 2012;10:33.
  21. Ahrends T, Spanjaard A, Pilzecker B, Babala N, Bovens A, Xiao Y, et al. CD4(+) T Cell Help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and Increased Tissue Invasiveness. Immunity. 2017;47(5):848-61 e5.
  22. Borst J, Ahrends T, Babala N, Melief CJM, Kastenmuller W. CD4(+) T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 2018;18(10):635-47.
  23. Melssen M, Slingluff CL, Jr. Vaccines targeting helper T cells for cancer immunotherapy. Curr Opin Immunol. 2017;47:85-92.
  24. Chang WC, Li CH, Huang SC, Chang DY, Chou LY, Sheu BC. Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma. Cancer. 2010;116(24):5777-88.
  25. Dovsak T, Ihan A, Didanovic V, Kansky A, Verdenik M, Hren NI. Effect of surgery and radiotherapy on complete blood count, lymphocyte subsets and inflammatory response in patients with advanced oral cancer. BMC Cancer. 2018;18(1):235.
  26. Riemann D, Cwikowski M, Turzer S, Giese T, Grallert M, Schutte W, et al. Blood immune cell biomarkers in lung cancer. Clin Exp Immunol. 2019;195(2):179-89.
  27. Xu YF, Lu Y, Cheng H, Shi S, Xu J, Long J, et al. Abnormal distribution of peripheral lymphocyte subsets induced by PDAC modulates overall survival. Pancreatology. 2014;14(4):295-301.
  28. Oh SY, Heo J, Noh OK, Chun M, Cho O, Oh YT. Absolute Lymphocyte Count in Preoperative Chemoradiotherapy for Rectal Cancer: Changes Over Time and Prognostic Significance. Technol Cancer Res Treat. 2018;17:1533033818780065.
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