Bayat, Mahnaz, Razavi Moosavi, Niloufar, Karimi, Najmeh, Rahimi, Moosa, Borhani-Haghighi, Afshin. (1402). Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D. سامانه مدیریت نشریات علمی, 20(3), 359-367. doi: 10.22034/iji.2023.96384.2432
Mahnaz Bayat; Niloufar Razavi Moosavi; Najmeh Karimi; Moosa Rahimi; Afshin Borhani-Haghighi. "Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D". سامانه مدیریت نشریات علمی, 20, 3, 1402, 359-367. doi: 10.22034/iji.2023.96384.2432
Bayat, Mahnaz, Razavi Moosavi, Niloufar, Karimi, Najmeh, Rahimi, Moosa, Borhani-Haghighi, Afshin. (1402). 'Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D', سامانه مدیریت نشریات علمی, 20(3), pp. 359-367. doi: 10.22034/iji.2023.96384.2432
Bayat, Mahnaz, Razavi Moosavi, Niloufar, Karimi, Najmeh, Rahimi, Moosa, Borhani-Haghighi, Afshin. Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D. سامانه مدیریت نشریات علمی, 1402; 20(3): 359-367. doi: 10.22034/iji.2023.96384.2432

Increased Serum Levels of IL-1β after Ischemic Stroke are Inversely Associated with Vitamin D

Iranian Journal of Immunology
دوره 20، شماره 3، پاییز 2023، صفحه 359-367    اصل مقاله (635.32 K)
نوع مقاله: Short Communication
شناسه دیجیتال (DOI): 10.22034/iji.2023.96384.2432
نویسندگان
Mahnaz Bayat1؛ Niloufar Razavi Moosavi1؛ Najmeh Karimi1، 2؛ Moosa Rahimi3؛ Afshin Borhani-Haghighi* 1، 4، 5
1Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran.
3Laboratory of Basic Sciences, Mohammad Rasul Allah Research Tower, Shiraz University of Medical Sciences, Shiraz, Iran.
4Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia.
5Hunter Medical Research Institute and the University of Newcastle, Newcastle, Australia.
چکیده
Background: The initial inflammatory reaction starts following occlusion in ischemic stroke (IS). Interleukin-1β (IL-1β) is a pro-inflammatory cytokine with a crucial role in the pathogenesis of neurodegenerative disorders.
Objective: To investigate the levels of IL-1β and vitamin D (VitD) in patients with IS compared with controls and their correlation.
Methods: The serum level of 25-OH VitD and IL-1β was assessed in 102 IS patients (0-24 h after stroke) and 102 controls with an enzyme-linked immunosorbent assay (ELISA) kit.
Results: We found a significant increase in IL-1β (80.14±6.8 vs. 60.32±4.1 pg/ml, p<0.05) and a decrease in VitD level (24.3±1.4 vs. 29.9±1.5 ng/ml, p<0.01) in the IS patients compared with the controls. There was a significantly positive correlation between the National Institutes of Health Stroke Scale (NIHSS) and IL-1β according to both the Spearman correlation (r=0.35, p=0.0003) and the linear regression (beta=0.255, p=0.014). Also, a significant negative association between VitD and NIHSS was detected by the Spearman correlation (r=-0.41, p<0.0001) and the linear regression (beta=-0.381, p=0.000). Moreover, we found a significant negative correlation (r=-0.26, p=0.006) between the serum levels of VitD and IL-1β in the patient group.
Conclusion: Ischemic stroke correlates positively with IL-1β and negatively with VitD levels. The speculated role of VitD deficiency in the evolution and severity of stroke may be justified by its role in the modification of inflammation.
کلیدواژه‌ها
Inflammation؛ Interleukin-1β؛ Ischemic Stroke؛ Vitamin D
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