Background: The experience of hot flashes during menopause has a negative effect on quality of life and can cause disturbance in the workplace and disrupt daily activities. Phytoestrogens in Salvia officinalis reduce menopause symptoms due to their anti-dopaminergic effects. This study was conducted to systematically review and summarize the results of clinical trials on the effect of Salvia officinalis on hot flashes in postmenopausal women. Methods: In this systematic review, databases including Pubmed, Web of Science, Cochrane library, Scopus, SID, and Magiran were searched using keywords such as menopause, hot flashes, Salvia officinalis, and herbal medicines; all possible combinations of these words were used with the Boolean operators of “OR” and “AND”. To evaluate the quality of articles, we used Cochrane’s Risk of bias tools. Results: After eliminating the duplicates, a total of 148 articles were found. Following the exclusion of irrelevant articles, 4 studies with number of 310 people were examined. Among them, 3 out of 4 studies examined the effect of Salvia officinalis on the frequency of hot flashes, 3 out of 4 studies examined the severity of hot flashes, and only 1 out of 4 studies examined the effect of Salvia officinalis on the duration of hot flashes. All 4 reviewed studies indicated that the use of Salvia officinalis reduced the frequency and severity of hot flashes in postmenopausal women. Meta-analysis results showed that the effect of Salvia Officinalis on the frequency [ES=-1.12 (%95 CI:-2.37; 0.14), I2=71%] of hot flashes in postmenopausal women was significant compared to placebo, but severity [ES=-2.05 (%95 CI:-6.53; 2.43), I2=70%] was not significant. Conclusion: Salvia officinalis can be used to reduce the frequency of menopausal hot flashes. Expansive use of this plant can be suggested in case it is confirmed in further investigations. |
- Burkman RT. Berek & Novak’s Gynecology. JAMA. 2012;308:516-7.
- Moghadam R, Ozgoli G, Molayi B, et al. Effect of omega3 on vasomotor disorders in menopausal women. Journal of Arak University of Medical Sciences. 2012;15:116-26. [In Persian]
- Speroff L, Fritz MA. Clinical Gynecologic Endocrinology and Infertility. 8th ed. USA: Lippincott Williams & Wilkins; 2011.
- Freedman RR. Menopausal hot flashes: mechanisms, endocrinology, treatment. The Journal of Steroid Biochemistry and Molecular Biology. 2014;142:115-20.
- Johns C, Seav SM, Dominick SA, et al. Informing hot flash treatment decisions for breast cancer survivors: a systematic review of randomized trials comparing active interventions. Breast Cancer Research and Treatment. 2016;156:415-26.
- Cunningham FG, Leveno KJ, Bloom SL, et al. Obstetrícia de Williams. 25th ed. Australia: McGraw Hill Brasil; 2021.
- Zare E, Nahidi F, Mojab F, Majd HA. The Effect of Pimpinella anisum on Treatment and Recurrence of Menopausal Hot Flashes: A Randomized, Controlled, Multicenter, Double-Blind, Parallel-Group Clinical Trial. Shiraz E-Medical Journal. 2022;23:e117385.
- Hickey M, Elliott J, Davison SL. Hormone Replacement Therapy. BMJ. 2012;344:e763.
- De Franciscis P, Conte A, Schiattarella A, et al. Non-hormonal treatments for menopausal symptoms and sleep disturbances: A comparison between purified pollen extracts and soy isoflavones. Current Pharmaceutical Design. 2020;26:4509-14.
- Ciotta L, Stracquadanio M, Pagano I, et al. Clinical effects of treatment with phytoestrogens in postmenopausal women. Minerva Ginecologica. 2012;64:15-22.
- Abdnezhad R, Simbar M. A review of the effective herbal medicines on hot flashes in menopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2020;23:107-19. [In Persian]
- Mohammed HA, Eldeeb HM, Khan RA, et al. Sage, Salvia officinalis L., Constituents, hepatoprotective activity, and cytotoxicity evaluations of the essential oils obtained from fresh and differently timed dried herbs: a comparative analysis. Molecules. 2021;26:5757.
- Heydarpour S, Sharifipour F, Salari N. Effect of aromatherapy using Salvia officinalis on sleep quality of postmenopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2020;23:50-7. [In Persian]
- Kim NC. Need for Pharmacopeial Quality Standards for Botanical Dietary Supplements and Herbal Medicines. Food Supplements and Biomaterials for Health. 2021;1:e10.
- Sadeghi H, Bakhshi M, Behboodi Z, et al. Effect of sage extract on hot flashes in postmenopausal women. Complementary Medicine Journal. 2013;2:324-35. [In Persian]
- Masoumi SZ, Shayan A, AhmadiNiya Tabesh R, et al. A comparative study on the effect of black cohosh and salvia on hot flashes in postmenopausal women. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2019;22:1-12. [In Persian]
- Dadfar F, Bamdad K. The effect of Saliva officinalis extract on the menopausal symptoms in postmenopausal women: An RCT. International Journal of Reproductive BioMedicine. 2019;17:287-92.
- Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, et al. The effect of Salvia officinalis extract on symptoms of flashing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. Journal of Family Medicine and Primary Care. 2020;9:1086-92.
- Bommer S, Klein P, Suter A. First time proof of sage’s tolerability and efficacy in menopausal women with hot flashes. Advances in Therapy. 2011;28:490-500.
- Wilfried D, Nina CDG, Silvia B. Effectiveness of Menosan® Salvia officinalis in the treatment of a wide spectrum of menopausal complaints. A double-blind, randomized, placebo-controlled, clinical trial. Heliyon. 2021;7:e05910.
- Gallagher J. Salvia officinalis for menopausal hot flashes: a pilot study. Focus on Alternative and Complementary Therapies. 2002;7:92-3.
- Lethaby A, Marjoribanks J, Kronenberg F, et al. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database of Systematic Reviews. 2013;2013:CD001395.
- Salehi-Pourmehr H, Ostadrahimi A, Ebrahimpour-Mirzarezaei M, Farshbaf-Khalili A. Does aromatherapy with lavender affect physical and psychological symptoms of menopausal women? A systematic review and meta-analysis. Complementary Therapies in Clinical Practice. 2020;39:101150.
- Mahboubi M. Evening primrose (Oenothera biennis) oil in management of female ailments. Journal of Menopausal Medicine. 2019;25:74-82.
- Abdi F, Roozbeh N. The effects of Humulus lupulus L.) hops) on menopausal vasomotor symptoms: a systematic review and meta-analysis. The Iranian Journal of Obstetrics, Gynecology and Infertility. 2016;19:9-17. [In Persian]
- Sarkis-Onofre R, Catalá-López F, Aromataris E, Lockwood CS. How to properly use the PRISMA Statement. Systematic Reviews. 2021;10:117.
- Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions. 2nd ed. UK: John Wiley & Sons; 2019.
- Harrer M, Cuijpers P, Furukawa T, Ebert DD. Doing Meta-Analysis with R: A Hands-On Guide. 1st ed. UK: Routledge (Taylor & Francis Group); 2022.
- Schwarzer G, Carpenter J, Rücker G. Meta-Analysis with R. Switzerland: Springer International Publishing; 2015.
- Higgins J, Tompson S, Deeks J, Altman D. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60.
- Egger M, Smith GD, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-34.
- Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-101.
- Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. Journal of Traditional and Complementary Medicine. 2017;7:433-40.
- Franco OH, Chowdhury R, Troup J, et al. Use of plant-based therapies and menopausal symptoms: A systematic review and meta-analysis. JAMA. 2016;315:2554-63.
- Chen MN, Lin CC, Liu CF. Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review. Climacteric. 2015;18:260-9.
- Eden JA. Phytoestrogens for menopausal symptoms: a review. Maturitas. 2012;72:157-9.
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