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Abu, Thomas, Ogbole, Omonike, Ajaiyeoba, Edith, Akinleye, Toluwanimi, Sanusi, Adedapo, Adeniji, Johnson. (1402). Cytotoxic effects of Nigerian Ethnomedicinal Plant Extracts on Three Cancer Cell Lines and their Antioxidant Properties. سامانه مدیریت نشریات علمی, 9(2), 135-146. doi: 10.30476/tips.2023.98386.1188
Thomas Abu; Omonike Ogbole; Edith O Ajaiyeoba; Toluwanimi E. Akinleye; Adedapo J Sanusi; Johnson Adeniji. "Cytotoxic effects of Nigerian Ethnomedicinal Plant Extracts on Three Cancer Cell Lines and their Antioxidant Properties". سامانه مدیریت نشریات علمی, 9, 2, 1402, 135-146. doi: 10.30476/tips.2023.98386.1188
Abu, Thomas, Ogbole, Omonike, Ajaiyeoba, Edith, Akinleye, Toluwanimi, Sanusi, Adedapo, Adeniji, Johnson. (1402). 'Cytotoxic effects of Nigerian Ethnomedicinal Plant Extracts on Three Cancer Cell Lines and their Antioxidant Properties', سامانه مدیریت نشریات علمی, 9(2), pp. 135-146. doi: 10.30476/tips.2023.98386.1188
Abu, Thomas, Ogbole, Omonike, Ajaiyeoba, Edith, Akinleye, Toluwanimi, Sanusi, Adedapo, Adeniji, Johnson. Cytotoxic effects of Nigerian Ethnomedicinal Plant Extracts on Three Cancer Cell Lines and their Antioxidant Properties. سامانه مدیریت نشریات علمی, 1402; 9(2): 135-146. doi: 10.30476/tips.2023.98386.1188

Cytotoxic effects of Nigerian Ethnomedicinal Plant Extracts on Three Cancer Cell Lines and their Antioxidant Properties

Trends in Pharmaceutical Sciences
مقاله 5، دوره 9، شماره 2، شهریور 2023، صفحه 135-146    اصل مقاله (538.47 K)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.30476/tips.2023.98386.1188
نویسندگان
Thomas Abu1، 2؛ Omonike Ogbole* 2؛ Edith O Ajaiyeoba2؛ Toluwanimi E. Akinleye2؛ Adedapo J Sanusi3؛ Johnson Adeniji4
1Bioresources Development Centre, Odi, National Biotechnology Development Agency, Abuja, Nigeria
2Department of Pharmacognosy Faculty of Pharmacy University of Ibadan Ibadan, Nigeria
3Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Nigeria
4W.H.O Polio Laboratory, Department of Virology, College of Medicine, University of Ibadan, Ibadan, Nigeria
چکیده
Several chemotherapeutic agents have been associated with cancer treatment but with numerous adverse effects. In this study, the cytotoxic and antioxidant effects of methanol extracts of ten selected plants from Nigerian ethnomedicine were assessed as a probable source of natural products for the treatment of cancer. The phenolics and flavonoid contents, and in vitro antioxidant assays (DPPH, nitric oxide, total antioxidant capacity, ferric reducing antioxidant power, metal chelating, lipid peroxidation) on the plant extracts were evaluated. In vitro cytotoxic effects of the extracts on Brine Shrimps, Rhabdomyosarcoma (RD), Breast (MCF-7), and Cervical (HeLa) cancer cell lines were also evaluated. The plant extracts demonstrated a broad spectrum of antioxidant properties. All the extracts exhibited moderate toxicity on brine shrimp. Pacrilima nitida exhibited the highest inhibition on the growth of RD (CC50=17.97 µg/mL) and MCF-7 (CC50=38.79 µg/mL) cell lines while Cocos nucifera exhibited the highest inhibition on the growth of HeLa (CC50=24.16 µg/mL). These plants exhibited a relatively cytotoxic and antioxidant effect and thus could contribute to anticancer drug discovery and many other disease conditions due to their antioxidant properties. 

تازه های تحقیق

Omonike Ogbole (Google Scholar)

کلیدواژه‌ها
Antioxidant؛ Breast؛ Cervical؛ Cytotoxic؛ Medicinal Plants؛ Rhabdomyosarcoma
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