LinkedIn

 آمار

تعداد نشریات20
تعداد شماره‌ها1,149
تعداد مقالات10,518
تعداد مشاهده مقاله45,415,520
تعداد دریافت فایل اصل مقاله11,291,328
Puriparthi, Lakshmi, Prasanthi, Akkineni, Talluri, Anil, Tumu, Venkatappa, Bomidika, Nagarjuna, Sresty, Madhusudhana, Alluri, Krishnam. (1402). Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques. سامانه مدیریت نشریات علمی, 15(1), 52-61. doi: 10.30476/mejc.2023.96091.1803
Lakshmi Venkataramana Puriparthi; Akkineni Naga Prasanthi; Anil Kumar Talluri; Venkatappa Rao Tumu; Nagarjuna Reddy Bomidika; Madhusudhana Sresty; Krishnam Raju Alluri. "Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques". سامانه مدیریت نشریات علمی, 15, 1, 1402, 52-61. doi: 10.30476/mejc.2023.96091.1803
Puriparthi, Lakshmi, Prasanthi, Akkineni, Talluri, Anil, Tumu, Venkatappa, Bomidika, Nagarjuna, Sresty, Madhusudhana, Alluri, Krishnam. (1402). 'Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques', سامانه مدیریت نشریات علمی, 15(1), pp. 52-61. doi: 10.30476/mejc.2023.96091.1803
Puriparthi, Lakshmi, Prasanthi, Akkineni, Talluri, Anil, Tumu, Venkatappa, Bomidika, Nagarjuna, Sresty, Madhusudhana, Alluri, Krishnam. Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques. سامانه مدیریت نشریات علمی, 1402; 15(1): 52-61. doi: 10.30476/mejc.2023.96091.1803

Feasibility of Dose Reduction to the Left Anterior Descending Coronary Artery without Compromising Target Volume Coverage Using Tomotherapy Techniques

Middle East Journal of Cancer
مقاله 6، دوره 15، شماره 1 - شماره پیاپی 57، فروردین 2024، صفحه 52-61    اصل مقاله (313.46 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/mejc.2023.96091.1803
نویسندگان
Lakshmi Venkataramana Puriparthi1؛ Akkineni Naga Prasanthi2؛ Anil Kumar Talluri1؛ Venkatappa Rao Tumu* 3؛ Nagarjuna Reddy Bomidika2؛ Madhusudhana Sresty1؛ Krishnam Raju Alluri2
1Department of Radiation Physics, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India
2Department of Radiation Oncology, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad, India
3Department of Physics, National Institute of Technology, Warangal, Telangana, India
چکیده
Background: Radiotherapy is associated with a high risk of heart disease in patients with left-sided breast cancer. Previously, the entire heart was considered an organ at risk (OAR) during planning. Studies have shown that the effect of radiation therapy depends on the dose to specific heart substructures. However, the tolerance dose of the left anterior descending coronary artery (LAD), an important cardiac substructure, is yet to be determined. This study aims to verify the feasibility of reducing the LAD dose with appropriate dose-volume constraints for patients undergoing left whole-breast radiotherapy, without compromising the target dose coverage, using tomotherapy techniques.
Method: This retrospective study generated tomohelical and tomodirect plans initially without considering the LAD as OAR in the treatment planning. To reduce the LAD dose, plans were regenerated by including the LAD as an OAR with appropriate dose constraints. The dose-volume histogram parameters of these plans were compared with those of the initial plans of the respective types.
Results: Tomohelical plans showed a 4.4% reduction in maximum dose and a 3.8% reduction in V15 for LAD, while tomodirect plans registered a 3% reduction in V15, with the conformity index remaining constant. Based on the LAD dosimetric results, considering the LAD as an OAR is associated with lower LAD doses without compromising the target volume coverage.
Conclusion: It is feasible to reduce the LAD dose without compromising target volume coverage or affecting other OAR doses in patients with left breast cancer, using tomotherapy techniques.

تازه های تحقیق

Venkatappa Rao Tumu (Google Scholar)

کلیدواژه‌ها
Heart diseases؛ Tomotherapy؛ Helical؛ Left-sided breast cancer؛ Coronary artery؛ LAD dose reduction
مراجع
  1. Early Breast Cancer Trialists' Collaborative Group (EBCTCG), Darby S, McGale P, Correa C, Taylor C, Arriagada R, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707-16. doi: 10.1016/S0140-6736(11)61629-2.
  2. Rehammar JC, Jensen MB, McGale P, Lorenzen EL, Taylor C, Darby SC, et al. Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005. Radiother Oncol. 2017;123(2):299-305. doi:10.1016/j.radonc.2017.03.012.
  3. McGale P, Darby SC, Hall P, Adolfsson J, Bengtsson NO, Bennet AM, et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden. Radiother Oncol. 2011;100(2):167-75. doi: 10.1016/j.radonc.2011.06.016.
  4. Schultz-Hector S, Trott KR. Radiation-induced cardiovascular diseases: is the epidemiologic evidence compatible with the radiobiologic data? Int J Radiat Oncol Biol Phys. 2007;67(1):10-8. doi: 10.1016/j.ijrobp.2006.08.071.
  5. Sardaro A, Petruzzelli MF, D'Errico MP, Grimaldi L, Pili G, Portaluri M. Radiation-induced cardiac damage in early left breast cancer patients: risk factors, biological mechanisms, radiobiology, and dosimetric constraints. Radiother Oncol. 2012;103(2):133-42. doi: 10.1016/j.radonc.2012.02.008.
  6.  Feng M, Moran JM, Koelling T, Chughtai A, Chan JL, Freedman L, et al. Development and validation of a heart atlas to study cardiac exposure to radiation following treatment for breast cancer. Int J Radiat Oncol Biol Phys. 2011;79(1):10-8. doi: 10.1016/j.ijrobp.2009.10.058.
  7. Nilsson G, Witt Nyström P, Isacsson U, Garmo H, Duvernoy O, Sjögren I, et al. Radiation dose distribution in coronary arteries in breast cancer radiotherapy. Acta Oncol. 2016;55(8):959-63. doi: 10.1080/0284186X.2016.1182209.
  8. Wennstig AK, Garmo H, Isacsson U, Gagliardi G, Rintelä N, Lagerqvist B, et al. The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors. Radiat Oncol. 2019;14(1):40. doi: 10.1186/s13014-019-1242-z.
  9. Shekel E, Levin D, Epstein D, Tova Y, Zalmanov-Faermann S, Pfeffer R. Is contouring the left anterior descending (LAD) artery necessary for left-breast patients?: A retrospective comparison between treated and revised plans. International Journal of Radiation Oncology, Biology, Physics. 2014;90(1):S265. doi:10.1016/j.ijrobp.2014.05.916.
  10. Nobnop W, Phakoetsuk P, Chitapanarux I, Tippanya D, Khamchompoo D. Dosimetric comparison of TomoDirect, helical tomotherapy, and volumetric modulated arc therapy for postmastectomy treatment. J Appl Clin Med Phys. 2020;21(9):155-62. doi: 10.1002/acm2.12989.
  11. Yeh HP, Huang YC, Wang LY, Shueng PW, Tien HJ, Chang CH, et al. Helical tomotherapy with a complete-directional-complete block technique effectively reduces cardiac and lung dose for left-sided breast cancer. Br J Radiol. 2020;93(1108):20190792. doi: 10.1259/bjr.20190792.
  12. Li XA, Tai A, Arthur DW, Buchholz TA, Macdonald S, Marks LB, et al. Variability of target and normal structure delineation for breast cancer radiotherapy: an RTOG Multi-Institutional and Multiobserver Study. Int J Radiat Oncol Biol Phys. 2009;73(3):944-51. doi: 10.1016/j.ijrobp.2008.10.034.
  13. Chiu ST, Wu PM, Cheng KF, Fok PH, Chiu G. Evaluation on dosimetric plan quality and treatment delivery time of dynamic jaw mode in TomoTherapy® for left-side breast cancer patients. Journal of Radiotherapy in Practice. 2021;1-8. doi:10.1017/s1460396921000522.
  14. Binny D, Lancaster CM, Harris S, Sylvander SR. Effects of changing modulation and pitch parameters on tomotherapy delivery quality assurance plans. J Appl Clin Med Phys. 2015;16(5):87-105. doi: 10.1120/jacmp.v16i5.5282.
  15. Hodapp N. The ICRU Report 83: prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT). [Article in German] Strahlenther Onkol. 2012;188(1):97-9. doi: 10.1007/s00066-011-0015-x.
  16. Atkins KM, Chaunzwa TL, Lamba N, Bitterman DS, Rawal B, Bredfeldt J, et al. Association of left anterior descending coronary artery radiation dose with major adverse cardiac events and mortality in patients with non-small cell lung cancer. JAMA Oncol. 2021;7(2):206-19. doi: 10.1001/jamaoncol.2020.6332.
  17. Atkins KM, Bitterman DS, Chaunzwa TL, Kozono DE, Baldini EH, Aerts HJWL, et al. Mean heart dose is an inadequate surrogate for left anterior descending coronary artery dose and the risk of major adverse cardiac events in lung cancer radiation therapy. Int J Radiat Oncol Biol Phys. 2021;110(5):1473-9. doi: 10.1016/j.ijrobp.2021.03.005.
  18. Nieder C, Schill S, Kneschaurek P, Molls M. Influence of different treatment techniques on radiation dose to the LAD coronary artery. Radiat Oncol. 2007;2:20. doi: 10.1186/1748-717X-2-20.
  19. Mathieu D, Bedwani S, Mascolo-Fortin J, Côté N, Bernard AA, Roberge D, et al. Cardiac sparing with personalized treatment planning for early-stage left breast cancer. Cureus. 2020;12(3):e7247. doi: 10.7759/cureus.7247.
  20. Barry A, Rock K, Sole C, Rahman M, Pintilie M, Lee G, et al. The impact of active breathing control on internal mammary lymph node coverage and normal tissue exposure in breast cancer patients planned for left-sided postmastectomy radiation therapy. Pract Radiat Oncol. 2017;7(4):228-33. doi: 10.1016/j.prro.2016.11.010.
  21. Kirby AM, Evans PM, Donovan EM, Convery HM, Haviland JS, Yarnold JR. Prone versus supine positioning for whole and partial-breast radiotherapy: a comparison of non-target tissue dosimetry. Radiother Oncol. 2010;96(2):178-84. doi: 10.1016/j.radonc.2010.05.014.
  22. Vayntraub A, Quinn TJ, Thompson AB, Chen PY, Gustafson GS, Jawad MS, et al. Left anterior descending artery avoidance in patients receiving breast irradiation. Med Dosim. 2021;46(1):57-64. doi: 10.1016/j.meddos.2020.07.006.
آمار
تعداد مشاهده مقاله: 3,082
تعداد دریافت فایل اصل مقاله: 413


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب