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Niu, Jianrong, Zhou, Hui, Tian, Rong, Wang, Xudong. (1402). Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice. سامانه مدیریت نشریات علمی, 20(2), 167-176. doi: 10.22034/iji.2023.97283.2494
Jianrong Niu; Hui Zhou; Rong Tian; Xudong Wang. "Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice". سامانه مدیریت نشریات علمی, 20, 2, 1402, 167-176. doi: 10.22034/iji.2023.97283.2494
Niu, Jianrong, Zhou, Hui, Tian, Rong, Wang, Xudong. (1402). 'Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice', سامانه مدیریت نشریات علمی, 20(2), pp. 167-176. doi: 10.22034/iji.2023.97283.2494
Niu, Jianrong, Zhou, Hui, Tian, Rong, Wang, Xudong. Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice. سامانه مدیریت نشریات علمی, 1402; 20(2): 167-176. doi: 10.22034/iji.2023.97283.2494

Estrogen Receptor Alpha Gene (ESR1) Facilitates Th2-immune Response and Enhances Th2 Cytokines in Experimental Atopic Dermatitis Mice

Iranian Journal of Immunology
مقاله 3، دوره 20، شماره 2، شهریور 2023، صفحه 167-176    اصل مقاله (1.63 M)
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22034/iji.2023.97283.2494
نویسندگان
Jianrong Niu1؛ Hui Zhou1؛ Rong Tian* 1؛ Xudong Wang2
1Department of Dermatology, Air Force Medical Center PLA, Beijing 100142, China.
2Southern Medical District of Chinese PLA General Hospital, Beijing 100853, China.
چکیده
Background: Molecular markers are involved in atopic dermatitis (AD) pathogenesis. The estrogen receptor (ESR)-1 gene, encoding ERα, is reported to express aberrantly in AD patients.
Objective: To detect the biological functions of ESR1 in 2,4 dinitrochlorobenzene (DNCB)-treated mice.
Methods: The DNCB-treated mice received a topical application of emulsion containing the 1,3-bis(4 hydroxyphenyl)-4-methyl-5-[4-(2-piperidinyl ethoxy) phenol]-1H-pyrazole dihydrochloride (MPP; an ESR1-selective antagonist) to dorsal skins and ears. Then the dermatitis scores, histopathological changes, and cytokine levels were evaluated.
Results: MPP specifically downregulated ESR1 expression in DNCB-applied mice. Functionally, application of MPP abolished the DNCB-induced promotion in dermatitis score. Additionally, MPP administration protected against DNCB-induced dermatitis severity, suppressed mast cell infiltration and reduced production of immunoglobulin E (IgE) and thymus and activation-regulated chemokine (TARC). Moreover, MPP treatment inhibited DNCB- induced production of Th2 cytokines and infiltration of CD4+ T cells.
Conclusion: ESR1 facilitates Th2-immune response and enhances Th2 cytokines in AD mice.
کلیدواژه‌ها
Antagonist؛ Atopic Dermatitis؛ ESR1؛ Inflammatory Cytokines؛ Mice
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