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Dayer, Dian, Bayati, Vahid, Ebrahimi, Mina. (1402). Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review. سامانه مدیریت نشریات علمی, 49(2), 65-76. doi: 10.30476/ijms.2023.95425.2678
Dian Dayer; Vahid Bayati; Mina Ebrahimi. "Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review". سامانه مدیریت نشریات علمی, 49, 2, 1402, 65-76. doi: 10.30476/ijms.2023.95425.2678
Dayer, Dian, Bayati, Vahid, Ebrahimi, Mina. (1402). 'Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review', سامانه مدیریت نشریات علمی, 49(2), pp. 65-76. doi: 10.30476/ijms.2023.95425.2678
Dayer, Dian, Bayati, Vahid, Ebrahimi, Mina. Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review. سامانه مدیریت نشریات علمی, 1402; 49(2): 65-76. doi: 10.30476/ijms.2023.95425.2678

Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review

Iranian Journal of Medical Sciences
مقاله 1، دوره 49، شماره 2، اردیبهشت 2024، صفحه 65-76    اصل مقاله (430.27 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.30476/ijms.2023.95425.2678
نویسندگان
Dian Dayer* 1؛ Vahid Bayati1، 2؛ Mina Ebrahimi3
1Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Department of Anatomy, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background: Some studies have evaluated the manipulation of the sonic hedgehog (Shh) signaling pathway to generate more efficient insulin-producing cells (IPCs). In a systematic review, we evaluated in vitro and in vivo studies on the effect of inhibition or activation of the Shh pathway on the production, differentiation, maintenance, and endocrine activity of IPCs. 
Methods: A systematic review was conducted using all available experimental studies published between January 2000 and November 2022. The review aimed at determining the effect of Shh manipulation on the differentiation of stem cells (SCs) into IPCs. Keywords and phrases using medical subject headings were extracted, and a complete search was performed in Web of Science, Embase, ProQuest, PubMed, Scopus, and Cochrane Library databases. The inclusion criteria were manipulation of Shh in SCs, SCs differentiation into IPCs, and endocrine activity of mature IPCs. Articles with incomplete data and duplications were excluded. 
Results: A total of 208 articles were initially identified, out of which 11 articles were included in the study. The effect of Shh inhibition in the definitive endoderm stage to produce functional IPCs were confirmed. Some studies showed the importance of Shh re-activation at late-stage differentiation for the generation of efficient IPCs. It is proposed that baseline concentrations of Shh in mature pancreatic β-cells affect insulin secretion and endocrine activities of the cells. However, Shh overexpression in pancreatic β-cells ultimately leads to improper endocrine function and inadequate glucose-sensing insulin secretion.
Conclusion: Accurate manipulation of the Shh signaling pathway can be an effective approach in the production and maintenance of functional IPCs.

تازه های تحقیق

Dian Dayer (Google Scholar)

کلیدواژه‌ها
Hedgehog proteins؛ Hedgehog؛ Pancreas؛ Insulin؛ Stem cells
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