Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population | ||
| Iranian Journal of Medical Sciences | ||
| مقاله 6، دوره 48، شماره 5، آذر 2023، صفحه 484-492 اصل مقاله (742.72 K) | ||
| نوع مقاله: Original Article(s) | ||
| شناسه دیجیتال (DOI): 10.30476/ijms.2022.95469.2683 | ||
| نویسندگان | ||
| Seyed Alireza Sobhani1، 2؛ Masoumeh Kheirandish* 1؛ Shideh Rafati3؛ Milad Rafat4؛ Roghayeh Shahbazi5؛ Abnoos Azarbad6؛ Masoumeh Mahmoodi1؛ Ebrahim Eftekhar1؛ Somayeh Kheirandish1 | ||
| 1Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 2Department of Pathology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 3Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 4Department of Medical Genetics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran | ||
| 5Department of Cellular and Molecular Medicine, School of Medicine, University of Ottawa, Ottawa, Canada | ||
| 6Department of Pharmacology, School of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin 10, Turkey | ||
| چکیده | ||
| Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a significant risk factor for cardiovascular diseases. LDL-C can be directly measured using various methods, but this requires expensive equipment. Currently, clinical laboratories estimate LDL-C based on Friedewald’s formula (FF). We aimed to develop a modified formula based on directly measured LDL-C (D-LDL-C) values in a large population in Southern Iran and compare the results with various other estimation formulas. Methods: The participants of this cross-sectional study were adults aged >18 years living in Southern Iran. Blood samples from 15,200 individuals were collected, and the measured lipid parameters were randomly divided into training (n=10,184) and validation (n=5,016) datasets. A new formula was developed using a linear regression model, and its accuracy was validated. Pearson’s correlation and Cohen’s kappa were used to determin the relationship between D-LDL-C and calculated LDL-C (C-LDL-C). Results: The developed formula for the estimation of LDL-C was 0.857 total cholesterol (TC)-0.915 high-density lipoprotein cholesterol (HDL-C)-0.115 triglycerides (TG). Based on our proposed formula, for TG<150 and TG≥150 mg/dL, there was a significant correlation between mean values of D-LDL-C and C-LDL-C (r=0.985 and r=0.974, respectively). Compared to other formulas, C-LDL-C obtained from the proposed formula had the highest correlation with D-LDL-C. The agreement between D-LDL-C and C-LDL-C for TC<200, 200-239, and ≥240 mg/dL was 80.8%, 63.2%, and 67.4%, respectively, indicating a higher level of agreement than other formulas. Conclusion: The new formula appears to be more accurate than FF when applied to the population of Southern Iran. | ||
تازه های تحقیق | ||
Seyed Alireza Sobhani (Google Scholar) Masoumeh Kheirandish (Google Scholar) | ||
| کلیدواژهها | ||
| Cardiovascular diseases؛ Cholesterol؛ HDL؛ Lipoproteins؛ LDL؛ Iran | ||
| مراجع | ||
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