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Sobhani, Seyed Alireza, Kheirandish, Masoumeh, Rafati, Shideh, Rafat, Milad, Shahbazi, Roghayeh, Azarbad, Abnoos, Mahmoodi, Masoumeh, Eftekhar, Ebrahim, Kheirandish, Somayeh. (1402). Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population. سامانه مدیریت نشریات علمی, 48(5), 484-492. doi: 10.30476/ijms.2022.95469.2683
Seyed Alireza Sobhani; Masoumeh Kheirandish; Shideh Rafati; Milad Rafat; Roghayeh Shahbazi; Abnoos Azarbad; Masoumeh Mahmoodi; Ebrahim Eftekhar; Somayeh Kheirandish. "Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population". سامانه مدیریت نشریات علمی, 48, 5, 1402, 484-492. doi: 10.30476/ijms.2022.95469.2683
Sobhani, Seyed Alireza, Kheirandish, Masoumeh, Rafati, Shideh, Rafat, Milad, Shahbazi, Roghayeh, Azarbad, Abnoos, Mahmoodi, Masoumeh, Eftekhar, Ebrahim, Kheirandish, Somayeh. (1402). 'Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population', سامانه مدیریت نشریات علمی, 48(5), pp. 484-492. doi: 10.30476/ijms.2022.95469.2683
Sobhani, Seyed Alireza, Kheirandish, Masoumeh, Rafati, Shideh, Rafat, Milad, Shahbazi, Roghayeh, Azarbad, Abnoos, Mahmoodi, Masoumeh, Eftekhar, Ebrahim, Kheirandish, Somayeh. Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population. سامانه مدیریت نشریات علمی, 1402; 48(5): 484-492. doi: 10.30476/ijms.2022.95469.2683

Development of a Modified Friedewald’s Formula to Calculate Low-Density Lipoprotein in an Iranian Population

Iranian Journal of Medical Sciences
مقاله 6، دوره 48، شماره 5، آذر 2023، صفحه 484-492    اصل مقاله (742.72 K)
نوع مقاله: Original Article(s)
شناسه دیجیتال (DOI): 10.30476/ijms.2022.95469.2683
نویسندگان
Seyed Alireza Sobhani1، 2؛ Masoumeh Kheirandish* 1؛ Shideh Rafati3؛ Milad Rafat4؛ Roghayeh Shahbazi5؛ Abnoos Azarbad6؛ Masoumeh Mahmoodi1؛ Ebrahim Eftekhar1؛ Somayeh Kheirandish1
1Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
2Department of Pathology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3Social Determinants in Health Promotion Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
4Department of Medical Genetics, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
5Department of Cellular and Molecular Medicine, School of Medicine, University of Ottawa, Ottawa, Canada
6Department of Pharmacology, School of Pharmacy, Eastern Mediterranean University, Famagusta, North Cyprus, via Mersin 10, Turkey
چکیده
Background: Elevated low-density lipoprotein cholesterol (LDL-C) is a significant risk factor for cardiovascular diseases. LDL-C can be directly measured using various methods, but this requires expensive equipment. Currently, clinical laboratories estimate LDL-C based on Friedewald’s formula (FF). We aimed to develop a modified formula based on directly measured LDL-C (D-LDL-C) values in a large population in Southern Iran and compare the results with various other estimation formulas.
Methods: The participants of this cross-sectional study were adults aged >18 years living in Southern Iran. Blood samples from 15,200 individuals were collected, and the measured lipid parameters were randomly divided into training (n=10,184) and validation (n=5,016) datasets. A new formula was developed using a linear regression model, and its accuracy was validated. Pearson’s correlation and Cohen’s kappa were used to determin the relationship between D-LDL-C and calculated LDL-C (C-LDL-C).
Results: The developed formula for the estimation of LDL-C was 0.857 total cholesterol (TC)-0.915 high-density lipoprotein cholesterol (HDL-C)-0.115 triglycerides (TG). Based on our proposed formula, for TG<150 and TG≥150 mg/dL, there was a significant correlation between mean values of D-LDL-C and C-LDL-C (r=0.985 and r=0.974, respectively). Compared to other formulas, C-LDL-C obtained from the proposed formula had the highest correlation with D-LDL-C. The agreement between D-LDL-C and C-LDL-C for TC<200, 200-239, and ≥240 mg/dL was 80.8%, 63.2%, and 67.4%, respectively, indicating a higher level of agreement than other formulas.
Conclusion: The new formula appears to be more accurate than FF when applied to the population of Southern Iran.

تازه های تحقیق

Seyed Alireza Sobhani (Google Scholar)

Masoumeh Kheirandish (Google Scholar)

کلیدواژه‌ها
Cardiovascular diseases؛ Cholesterol؛ HDL؛ Lipoproteins؛ LDL؛ Iran
سایر فایل های مرتبط با مقاله
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